best cbd oil for inflammation review

Best CBD Gummies for Pain & Inflammation: Top 5 CBD Brands of Hemp Gummies [2022]

If you have aches and pains, CBD may be able to help. Whether it is a pain in your back from working all day long or a particularly tough training session at the gym, CBD gummies might be able to provide you some relief.

There are studies that indicate its efficacy for physical pain. Granted, these supplements are not meant to treat, cure, prevent or diagnose any disease, but they could help you relax.

Plus, you do not need a prescription to enjoy them, and they are legal nearly everywhere in the U.S. If you are ready, let’s read about the best CBD gummies for pain.

Top 5 Best CBD Gummies For Pain & Inflammation:

    – Overall Best CBD Gummies for Pain Relief – Best CBD Gummies for Pain & Inflammation; Turmeric CBD Gummies – Most Potent CBD Edibles for Inflammation – Full Spectrum CBD Gummies for Joint Pain Relief – Popular Online Cannabis Brand for Pain Relief

Here are the detailed reviews of our top picks:

#1. Exhale Wellness – Overall Best CBD Gummies for Pain Relief

CBD can bring relief, studies say, and Exhale Wellness can deliver. They use hemp from the USA, which is non-GMO, and transform it into delicious, sugar-coated gummies that are guaranteed to delight and help you feel relief. They are vegan and great for people following a clean eating lifestyle.

The brand is based out of California and partners with farmers out of Colorado to provide the hemp used in their products.

The gummies they offer are lab-tested, federally compliant, and taste great. The company’s mission is to provide everyone with hemp that helps, so offering nothing but the best is important to them.

There are 30 gummies in every bottle, and each gummy contains 25mg of CBD. One gummy is usually going to be enough to get you feeling right again, but the dosage will vary, especially if you have a higher tolerance to CBD.

The gummies are available in packages of assorted fruit flavors. This variety keeps things interesting and tasty.

Highlights

Exhale Wellness is well-known for their excellence in Delta-8 products, but the brand has expanded this attention to quality in their line of CBD gummies, flower, pre-rolls, and oil.

The team making the gummies is a cannabis-loving group with experience mostly in the sector of natural food. The brand is known for making CBD products that are sourced from nature, a real selling point for those seeking natural wellness methods.

The company includes laboratory testing results right on their website and Certificates of Analysis for every item on the site. Every item sold has undergone rigorous and stringent testing, so you can be sure it is safe.

The company is transparent about everything they do, which is great news for customers and people looking for CBD that’s going to do what it says.

The gummies are appropriately priced for the high level of quality you get along with the dosage. While there may be cheaper alternatives available out there, with Exhale, you can be sure you are paying for a safe and high-quality product. New buyers can also take advantage of a 20% off coupon, so try them today.

Pros
  • Vegan gummies
  • Choose between 750mg or 1500mg
  • Subscription saves 25% on monthly purchase
  • Third-party lab tested
  • Colorado-sourced hemp
Cons
  • Only available online

#2. BudPop – Best CBD Gummies for Pain & Inflammation; Turmeric CBD Gummies

Next up on our list is BudPop. This brand offers three varieties of CBD gummies for sale. Their gummies formulated specifically for pain and recovery are called CBD + CBG & Turmeric. These gummies are good if you have aches and pains related to exercise, manual labor, or just intense physical activity. CBD and CBG provide a synergistic approach to relieving daily aches and pain. The addition of black pepper and turmeric may also help with inflammation and improve digestion. Just take one gummy every 6 hours for relief.

BudPop also offers Sleep gummies if you have pain at night. CBD and CBN join forces and provide this great natural sleep aid. You will love how you doze off effortlessly and sleep like a baby. Just take 1-2 gummies every 6 hours and sleep like a rock.

Lastly, the brand produces Calm gummies. These use Ashwagandha and CBD to get you relief. They are great for improving your focus and keeping your mind steady. If you need to calm down and reduce anxiety, then try these gummies out.

This company is one many people have found helpful in the past year. Their attention to quality has earned BudPop a favorable reputation among CBD lovers. They are trustworthy and offer buyers a money-back guarantee on their purchases. The gummies are also tested using a third-party lab, with results available to view online.

Made with Nevada hemp, these gummies are clean, safe, and delicious.

Highlights

The gummies have a 12-month shelf life, and storing them in a dry, cool place will help keep them fresh. They are also compliant with all U.S. Farm Bill regulations and do not contain greater than 0.3% delta-9 THC.

The hemp is Nevada-grown, and every part of this gummy purchase- the bottle, the cap, the gummy- is made in the USA, which gives people meaningful jobs and assurance to customers they are getting a good product.

Another benefit is that the gummies are made using natural ingredients. They are vegan and sweetened using organic cane sugar. Their CBD + CBG & Turmeric gummies are available in a tasty orange flavor, while their other varieties taste like mixed berries.

All lab tests are performed by ACS Laboratories. BudPop offers discounts to active military and veterans as well as people who are disabled. So, be sure to email them to start getting these discounts if you fall into that group.

Pros
  • Discounts for active military, veterans, and those with disabilities
  • Made in the U.S.
  • Vegan gummies
  • Third-party lab tested
  • Can help with specific ailments
Cons
  • Only available online
  • 30-day money-back guarantee is only for unopened items

#3. Hollyweed CBD – Most Potent CBD Edibles for Inflammation

This brand is the brainchild of artist Zach Fernandez, who created the “Hollyweed” exhibit back in 2017, and a group of Californian entrepreneurs with wellness at the forefront of their business.

Hollyweed started their business with the desire to establish consistency and a sense of transparency within the CBD sales niche, according to the “About Us” part of their site. Their business is founded on six tenets, specifically the social, environmental, intellectual, physical, and spiritual aspects of wellness.

The gummies are ideal for people with a real affinity for sweets and who require serious relief from aches and pains. They are allergen-free, vegan, and devoid of any artificial colors or flavors.

The gummies are sold in the shape of a cube. This is great for your grasp, and there is 30 total in every bag. A few different potencies are available for purchase.

Highlights

HollyweedCBD has such great service that you will want to shop there again and again. All contact info is listed at the bottom of the site, so drop them a line or give them a ring. You can easily ask any questions or address any concerns you have.

Next, check out their return policy for a fair and easy exchange/refund should you need it. You are asked to use their items for at least 30 days, and if you do not find that you are satisfied, you can send them back for a refund.

On top of that, there is a 15-day grace period as well. So, if you are a bit late contacting them for a return, don’t worry. Fill out their “Refund Request Form” and get it started. If you were sent the wrong item or are missing an order, they can help you solve it and ensure your satisfaction.

Pros
  • Delicious vegan gummies
  • 2018 Farm Bill Compliant
  • Uses organic, natural ingredients
  • Third-party lab tested
  • Subscribe & save for a 25% discount
Cons
  • Flavors of gummies not listed on product page

#4. Cheef Botanicals – Full Spectrum CBD Gummies for Joint Pain Relief

Love Full spectrum hemp? Want to enjoy the entourage effect? Then you need to get to Cheef Botanicals. They want to tell the world about what hemp can do for them and do so in a tasty way. So, Cheef Botanicals Gummies were made, and customers just can’t get enough.

The company offers lots of other helpful CBD items as well for sale- namely tinctures, capsules, and smokable flower. The gummies are great because you can take them anywhere and enjoy them anytime.

All CBD products sold by Cheef are tested using a third-party laboratory to ensure they are clean and free of contaminants such as heavy metals and pesticides. The CBD gummies are also manufactured with full spectrum CBD oil, which gets you that entourage effect.

Vegans will rejoice when they learn that gummies are made without gelatin. They are naturally made and great for people everywhere, especially those following clean eating diets.

All the ingredients in the CBD gummies are organic. There are also varying potencies available, whether you have severe pain or chronic pain. For starters, there is 300mg, which is good if you are dealing with minor aches and pains or are new to CBD. Each gummy contains 10mg of CBD. The next highest dosage is 750mg, ideal for people who are experienced users of CBD but have a little more than mild pains and aches.

Beyond that is 1500mg, which offers 50mg of CBD in every gummy for the best relief you’ll find anywhere. Cheef’s highest strength for these gummies comes in their 3000mg package, which includes 30 gummies with 100mg of CBD each.

Highlights

Cheef is a company with customer interest at heart. You see this in how they make their gummies and how they display their lab tests prominently on their website. They even indicate that they started their business to fill the need for organic CBD items.

This is a group with knowledge in what they do, too. Combined, the team has 25 years of experience with organic foods. This experience, plus their desire to help others, has created the top-quality gummies and other CBD products offered for purchase.

The company ships to the United States as a whole. So, fret not if you live in a state where CBD is limited or hard to find. Place the order, and before you know it, your relief will arrive.

Pros
  • 25% off is offered to new buyers
  • They ship to all 50 states
  • Organic gummies
  • Third-party lab tested
  • 30-day money-back guarantee
Cons
  • No option to buy a single flavor; only available in mixed-flavor packages

#5. FAB CBD – Popular Online Cannabis Brand for Pain Relief

Is pain and inflammation keeping you up at night? What if a powerful blend of CBD, GABA, Ashwagandha, Melatonin, 5-HTP, and L-theanine could help you get the sleep you deserve?

Then FAB CBD is the place you need to go. They offer delicious gummies that are safe, effective, and of course, third-party lab-tested for safety. This company has been operating since 2017, which has given them time to perfect their business and learn what customers want in their CBD.

This has led to gummies with a pleasing and soft texture, delicious flavor, and of course, they are free of allergens, GMOs, and contaminants. These gummies will not make you high and are federally compliant.

They use the CO2 method of extraction to process the hemp used in making the gummies. This means that no solvents are used in the creation of hemp oil. Therefore, you can be assured that the final product is devoid of any impurities.

The group behind FAB CBD is knowledgeable and understands exactly how to create and perfect great CBD items with only the finest cannabinoids. The great taste and effectiveness will be your proof.

There are two gummies you can choose from. The “Nighttime” gummies are acai berry flavored. You will enjoy 12.5mg CBD in every tasty chew. The brand also has an “Anytime” gummy available.

The “Anytime” gummy features a delicious fruit flavor and is perfect when you just want to refocus and calm your mind. You’ll feel a sense of calm and clarity with these broad spectrum CBD gummies, plus it could help you alleviate daytime pain and inflammation.

Highlights

The company tests all of its gummies with ProVerde Labs. This is an ISO-recognized lab, and all you have to do is go to the bottom of their website and click “Lab Reports” to see them. You can also head to the ProVerde site and ask any follow-up questions you may have.

We were also glad to note that the hemp used in making these broad spectrum CBD gummies is sourced from Colorado. This is a state that loves hemp and grows it well.

Lastly, do not let the price turn you away. For starters, you can pay with Sezzle to make it easier. Moreover, the price is indicative of the quality that FAB CBD puts into all of its gummies. Read for yourself the customer reviews to see proof that these are some of the best available.

Pros
  • Delicious taste of the CBD gummies
  • Pay over time using Sezzle
  • Third-party lab tested
  • Great customer service
Cons
  • Only one potency is offered for Nighttime and Anytime CBD gummies

How We Made Our List of the Best CBD Gummies for Pain Relief:

There are no set criteria for what makes a CBD supplement great, so we decided to create our standards. We thought about what we wanted for family or a friend if we had to recommend a CBD brand to them.

So, bearing this in mind, we used the following standards in the creation of this list:

  • Customer Thoughts

Perhaps the most important part of all is what customers thought of the CBD gummies. After all, these are the people who spent their hard-earned money on them- and besides, everyone reads reviews on things before they purchase them.

So, we read over reviews with a fine-tooth comb and an eye for the details. Did customers enjoy their purchase- did it get them relief? Did they experience alleviation of chronic pain and inflammation? If we noted enough good reviews, it made it onto the list.

  • Dosing/Labeling

If you have never used CBD before, you might be a little confused about how much you need to take. Therefore, we wanted to include CBD products that listed the dosage amount on the label, making it easier for new users.

You should ultimately work with your doctor to figure out a dose that is right for you, but the labels offer a starting line you can use to learn what works. It is easy to cut broad spectrum CBD gummies in half or simply take another one.

  • Ingredients

Fake CBD products are out there; they might take the form of candy with just a little CBD in it, or gummies packed with sugar or gelatin, or worst of all, impure ingredients. So, we made sure to include CBD gummies with hemp grown in the United States.

Hemp from other countries doesn’t have the same quality as U.S. hemp does. Therefore, hemp farmers in the U.S. must follow quality standards that are unlike anywhere else. Also, the soil quality of the U.S. is ideal for hemp.

Aside from the hemp, we also checked for pure ingredients- namely, organic ones. We also made sure the CBD gummies were free of allergens and GMOs.

  • Laboratory Tests

It is important to look for third-party lab testing on any CBD product you buy. After all, tainted CBD items are a real threat, as are items that claim to have CBD but don’t have the potency specified.

Thus, make sure the company has laboratory results you can read over. These tests mean the company has sent a sample of CBD products off to the lab for testing.

It ensures their items are pure and free of contaminants, pesticides, herbicides, heavy metals, and other impurities you don’t want. If the CBD company did not have recent third-party lab results, we did not include them on the list.

Buying Guide – Best CBD Edibles for Pain & Inflammation Relief

Don’t know what you need when it is time to purchase those best CBD gummies for pain relief? Worry not, for we have created this handy buying guide.

Keep it bookmarked for later use or copy this text into a doc of your own, print it, and use it while shopping. You will find that it is much easier to choose CBD gummies with it.

  • Hemp From the USA

United States hemp is one of the best, if not the best overall, hemp you can find in the world. You want to make sure that the hemp used in your CBD gummies comes from the U.S.

Farmers in the U.S. must follow hemp farming standards to ensure quality. Plus, the soil of America is ideal for hemp cultivation.

Industrial hemp is mostly free of THC, making it compliant with the U.S. Farm Bill (meaning it has 0.3% or less delta-9 THC).

This will ensure you do not get a psychoactive high from using such CBD gummies. However, it illustrates the importance of reviewing lab tests.

  • Coating vs. Infusion

Coated means that after the gummy has been made, a machine is used to spray the surface of the treat.

With infusion, the quality is better, and the potency is increased. The product’s shelf life also gains substantial improvements.

The dosing is more accurate as well when you choose hemp-infused CBD gummies. Plus, CBD gummies infused with cannabidiol will always have the amount of CBD they say they have.

Meanwhile, coated CBD gummies usually don’t lab-test as accurately as infused, and the amount of CBD they contain is varied.

  • Read Over the Ingredients

For starters, make sure the hemp used in your gummy is from the U.S.

Second, read the label to ensure the gummy fits your lifestyle and beliefs.

What do we mean by this? For starters, CBD gummies that contain gelatin are unsuitable for certain people- for instance, vegans.

Third, verify the gummy doesn’t contain ingredients you are personally against- for example, some people do not want artificial sweeteners in their foods.

You will also want to make sure that your gummy contains a sweetener you can live with. Here are some examples of sweeteners you may find in the gummy:

Organic juices: Natural veggie/fruit juices are great because they offer you a sweet taste with no artificial flavoring. The health benefits of CBD and these fruit/veggie juices are perfect all-around and taste great.

Organic Cane Sugar: Organic cane sugar is free of pesticides. It is unrefined and has a tasty and familiar flavor, thanks to its minimal processing. It offers nutrients found in cane juice. This type of sugar also possesses antioxidant characteristics.

Tapioca: Organic tapioca starch is great for people who want sweetness but live a natural lifestyle. It offers a neutral but delightful flavor. It also provides a boost of quick energy. It is not unlike the tapioca pearls that are used in Boba teas. This provides a soft and delicious texture/flavor for broad spectrum CBD gummies.

  • Reviews Are Important

Be sure to spend a little time reading over the lab testing reports and the product pages to see what customers genuinely thought about their product. This is the best method to find out whether or not the product is worth your money.

You should look for people that had the same problems as yourself and see how it helped them out. Taking just a little time to see how others got along with the product can help you determine if it is a good choice.

  • Benefits Matter

Some best CBD gummies for pain are designed to be used all the time. Others are just for daytime use. Meanwhile, others can help you with inflammation, as is the case with the BudPop Turmeric variety.

Be sure that you read over the benefits of these broad spectrum CBD gummies carefully, as they can impact how you feel. For instance, buying a nighttime gummy and using it during the day would only make you feel relaxed and sleepy when you are supposed to be alert.

You should also pay attention to the spectrum of the hemp used. For example, full spectrum contains all helpful terpenes, broad spectrum contains some of them, while CBD isolate means only CBD is included.

FAQs Regarding CBD Gummy Edibles for Pain:

Q1. Are CBD gummies safe to eat?

When you follow your healthcare provider’s recommendations for dosing/the jar’s dosing instructions, yes- these CBD gummies are great.

The CBD gummies for pain/anxiety have nothing for you to concern yourself with when you think about side effects. For instance, you need not worry about getting high when using these CBD gummies.

Be sure to purchase from a reliable brand, like the ones we featured today, and read over/understand all laboratory testing to ensure your safety. Do not forget to read customer reviews as well.

Q2. Can you take too much CBD? What is a toxic dose?

There are few studies done on toxic CBD levels. One study from 2011 indicates that 20,000mg CBD, taken at one time, would be the toxic amount.

You would have to consume a lot of CBD for this to happen.

So long as you follow the recommended dosing amounts as recommended by your healthcare provider/dosing instructions on the jar, you shouldn’t have anything to worry about. So, do not worry if you feel as though you have taken one broad spectrum CBD gummy too many.

Q3. What dosage is right for me?

This will vary from person to person, and we highly recommend that you speak with your doctor to figure out the dosage that’s right for you. If you are treating physical pain and inflammation, you may need a larger dose depending on that chronic pain so that a doctor can help.

You should begin with a small dose and work upwards. You might start with a 20mg gummy and see how it feels. If you want more, you could cut a gummy in half for 30mg or take two for a total of 40mg. Eventually, you will find what works for you, and you can take just what you need.

Q4. Why should I use CBD gummies and not a tincture/vape/flower?

For starters, CBD gummies/edibles are safer than vaping and smoking- it is common knowledge these actions are not good for our lungs.

Second, tinctures have to be held under the tongue, but this can be hard to do.

Plus, it is harder to take liquids on airplanes. Meanwhile, CBD gummies are discreet, portable, and taste great.

Q5. Are there any adverse side effects to using CBD gummies?

According to the Mayo Clinic, CBD is often well-tolerated by the person using it. However, there are some side effects users should know about before they start using it.

For starters, CBD may lead to dry mouth, fatigue, drowsiness, and lowered appetite. In some cases, diarrhea has been reported. In addition, CBD could interact with medications you are taking- for example, blood thinners.

The purity of CBD products and their dosage is another concern. Many of them have less than the amount of CBD their label states, and some contain THC.

As a result, you must read lab tests carefully and speak with your physician before using these CBD gummies.

Conclusion – Best CBD Brands for Pain Gummies Online

Thank you for taking the time to learn about these tasty edibles and what they can do for our aches and chronic pain.

Best CBD gummies for pain are one of the most fun ways to get relief. It’s like enjoying a treat but also knowing that help is on the way. You may also find that the anxieties and insomnia that come with your pain and inflammation also fade away with the use of these CBD gummies.

Every person is different, so please talk with your physician about a dose that works for you. They can help you work out a dose that’s ideal for you, and you can buy accordingly. Any of these quality brands are sure to help. Good luck and enjoy!

CBD Oil for Chronic Fatigue Syndrome

Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles, California.

Chronic fatigue syndrome (CFS or ME/CFS) is an extremely difficult illness to treat. It features dozens of symptoms believed to stem from the dysregulation of multiple systems throughout the body. Cannabidiol (CBD) oil is a hot, up-and-coming treatment right now that’s being touted as a fix for all kinds of diseases. It’s only natural that a lot of people with ME/CFS would develop an interest in CBD oil as a possible treatment.

But is CBD a safe and effective treatment for this complex and debilitating disease? Thus far, we have no specific research on CBD for ME/CFS, so it's too early to have an answer to that question.

Another possible deterrent for people considering this treatment is that CBD oil—which comes from hemp—gets wrapped up in the controversy over medical marijuana. That may make some people hesitant to try it. Additionally, it's been hard to find a straight answer about whether it's legal, but that concern should be going away soon.

Nusha Ashjaee / Verywell

What Is CBD Oil?

CBD stands for "cannabidiol," which comes from the cannabis plant. That's the same plant that gives us marijuana. However, CBD—as an oil or in other forms—doesn't have psychoactive properties. That means it doesn't provide the "high" associated with marijuana.  

The substance in marijuana that gets you high is called THC (tetrahydrocannabinol).   Growers who want to maximize the plant's psychoactive effect use breeds and techniques that result in higher levels of THC. On the other hand, cannabis that's grown for hemp is generally richer in CBD than THC, and that's where CBD comes from.

CBD oil can be used in several different ways. You can smoke it (typically in vape pens), take it in capsule form, use it sublingually (under the tongue), use oral sprays or drops, or apply it topically to your skin. A crystalline form of pure CBD is also available, which is generally taken sublingually.

CBD products that are extracted from cannabis are being used for a lot of medical purposes, and you can find many claims online about miraculous results.

But are these claims true? And would it work as well for you? From a scientific standpoint, the answers are more like "we don't know" and "possibly" and "some claims appear to be true" than a firm "yes," and it depends on which claims you're looking at.

People are using CBD oil for a whole lot of different medical purposes, including:

  • Chronic pain and inflammation, including neuroinflammation (a suspected feature of ME/CFS)
  • Social anxiety disorder
  • Halting the growth of cancerous tumors
  • The pain of glaucoma , especially in children
  • Bipolar disorder
  • Schizophrenia
  • Movement problems caused by Huntington’s disease
  • Help with smoking cessation

As of June 25, 2018, CBD oil has been approved by the U.S. FDA as an oral solution (Epidiolex) for the treatment of seizures associated with two very severe forms of epilepsy that usually affect children: Lennox-Gaustaut and Dravet syndromes.  

Research in the United States for other diseases is still in the early stages. That's because legal restrictions have for decades made it extremely difficult to study the medical benefits of marijuana or any of its components, which are called cannabinoids. Promising research is being done, though, on multiple conditions. Down the road, it's likely that we'll eventually see many applications submitted to the FDA.

CBD Research and ME/CFS

Anyone who's studied ME/CFS for very long will not be shocked to hear that, so far, we don't have any research done on CBD oil as a treatment for this disease. That doesn't mean we don't know anything, though.

CBD is being researched for numerous conditions, and many of those conditions share features with ME/CFS. While we can't say for certain that those results apply to similar conditions, they provide some basis for informed speculation.

Also, we're likely to see CBD investigated for ME/CFS before long, for several reasons.

First, we just don't have good treatments for ME/CFS. In fact, none are FDA approved. And while dozens of different medications and other interventions are used to help lessen the symptoms, many of them are only marginally effective and only help a fraction of those with the condition. Side effects tend to be a problem for this group, as well.

Second, we have a pain epidemic in the U.S. While not all ME/CFS involves pain, many cases do. Current treatments are inadequate, though, so there's a big financial incentive to find something that's better at relieving ME/CFS pain.

Third, we're currently struggling with an opioid addiction and overdose epidemic in the U.S. Several studies have shown that when a state legalizes marijuana, either medicinally or recreationally, the number of opioid prescriptions drops. That's good news for healthcare providers looking for safer pain treatments, for law enforcement agencies struggling to control the tide of illegal use, and for lawmakers trying to find solutions.

Fourth, CBD oil is believed to be effective against pain and inflammation, and, in its pure form, it's generally regarded as safe. Especially in light of the theory that ME/CFS is related to neuroinflammation, and the wealth of evidence pointing to it being an inflammatory disease, it's pretty obvious that there's a potential benefit that should be explored.

Finally, while anecdotal evidence isn't proof of anything, we already have an abundance of it from people with ME/CFS. When patients with difficult-to-treat conditions tell their healthcare providers something works, you can bet it gets them interested.

A 2017 ​paper published in Expert Opinion on Therapeutic Targets suggested CBD as a possible way to diminish the activity of brain cells called glia that can lead to central sensitization. That’s a hypersensitive central nervous system and a major feature of ME/CFS and other central sensitivity syndromes such as fibromyalgia, irritable bowel syndrome, and migraine.

CBD is believed to help with your body's homeostasis, which is keeping things like temperature, respiration, and blood flow in proper balance. Homeostasis tends to be out of balance in ME/CFS.

While it's less well documented in ME/CFS, a condition called endocannabinoids deficiency, characterized by lower amounts of naturally produced endocannabinoids in certain individuals, has been linked to fibromyalgia, making cannabis products a promising treatment.

A 2016 review published in Cannabis and Cannabinoid Research found evidence that CBD is effective in treating migraine and irritable bowel syndrome, which are related to ME/CFS. It also stated that some cannabis-based treatments appeared effective for fibromyalgia. The authors stated that CBD is often preferable to patients because it doesn’t include the high and other effects of THC.

As mentioned earlier, several studies have suggested that CBD can fight inflammation. That's a big deal for a disease that research links to chronic inflammation, and possibly to neuroinflammation as an underlying cause.

A 2017 French study on Alzheimer’s disease suggests that CBD lessens oxidative stress, diminishes mitochondrial dysfunction, and suppresses pro-inflammatory activity. All of those things could prove helpful against known and suspected dysfunctions associated with ME/CFS.

A 2011 study out of Italy suggested that CBD may lower intestinal inflammation via control of the neuro-immune axis. While that study was on inflammatory bowel disease, changes to the neuro-immune axis could be beneficial in ME/CFS, as well.

Side Effects

We don't have a full picture of the possible side effects of CBD. Some reported side effects include:  

  • Changes to liver enzymes used to process drugs
  • Dry mouth
  • Low blood pressure
  • Lightheadedness
  • Drowsiness
  • Increased tremor in Parkinson's disease, at high doses

The following effects are possible but require more study, according to the World Health Organization:

  • Alteration of hormonal levels
  • Immune system stimulation at low levels, and immune suppression at higher levels

The immune system effects will be especially important for ME/CFS, which is believed to involve a chronically overactive immune system.

Addiction and abuse don't appear to be problems with CBD, and it appears to have a low toxicity level, which means that it takes a lot to overdose.

Is It Legal?

When the 2018 Farm Bill was signed into law, it made hemp an agricultural product. That means products made from hemp—including CBD—are legal at the federal level.

However, some states and municipalities have passed laws specifically banning hemp products or CBD. Technically, federal law overrides state law. That doesn't mean, though, that your state or town will automatically stop making arrests and pressing charges under its CBD laws.

If you're in an area with laws prohibiting CBD, you may want to consult a legal expert on whether it could be a problem for you. Better safe than sorry.

The website ProCon.org has information about which states have laws specific to CBD oil. A site called Governing maintains a map of where marijuana is legal in some form.

A Word from Verywell

You have a lot to consider when it comes to any form of treatment, and even more when it comes to CBD. Be sure to consider the pros and cons, including the legal ones. Discuss this option with your healthcare provider to make sure you're not endangering your health. As with any treatment, watch for side effects.

With legal changes in-store and more research coming, things may change rapidly when it comes to CBD oil and other cannabis-based treatments. It's likely that we'll know a great deal more about the effectiveness and safety of these products a few years from now.

Chronic Fatigue Syndrome Doctor Discussion Guide

Get our printable guide for your next doctor's appointment to help you ask the right questions.

Khan MI, Sobocińska AA, Czarnecka AM, Król M, Botta B, Szczylik C. The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory. Curr Pharm Des. 2016;22(12):1756-66. doi:10.2174/1381612822666151211094901

Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. Cannabinoids as novel anti-inflammatory drugs. Future Med Chem. 2009;1(7):1333-49. doi:10.4155/fmc.09.93

Burstein SH, Zurier RB. Cannabinoids, endocannabinoids, and related analogs in inflammation. The AAPS Journal. 2009 Mar;11(1):109-19. DOI: 10.1208/s12248-009-9084-5.

De Filippis D, Esposito G, Cirillo C, et al. Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis. PLoS One. 2011;6(12):e28159. DOI: 10.1371/journal.pone.0028159.

Hill KP, Saxon AJ. The role of cannabis legalization in the opioid crisis. JAMA internal medicine. 2018 May 1;178(5):679-680. DOI: 10.1001/jamainternmed.2018.0254.

Nijs J, Loggia ML, Polli A, et al. Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients? Expert opinion on therapeutic targets. 2017 Aug;21(8):817-826. DOI: 10.1080/14728222.2017.1353603.

Piomelli D, Weiss S, Boyd G, Pacula RL, Cooper Z. Cannabis and the opioid crisis. Cannabis and cannabinoid research. 2018 Apr 1;3(1):108-116. DOI: 10.1089/can.2018.29011.rtl.

Russo EB. Clinical endocannabinoid deficiency reconsidered: current research supports the theory in migraine, fibromyalgia, irritable bowel, and other treatment-resistant syndromes. Cannabis and cannabinoid research. 2016 Jul 1;1(1):154-165. DOI: 10.1089/can.2016.0009.

Silvestri C, Di Marzo V. The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders. Cell metabolism. 2013 Apr 2;17(4):475-90. DOI: 10.1016/j.cmet.2013.03.001.

Vallee A, Lecarpentier Y, Guillevin R, Vallee JN. Effects of cannabidiol interactions with Wnt/B-catenin pathway and PPARy on oxidative stress and neuroinflammation in Alzheimer's disease. Acta biochimica et biophysica Sinica. 2017 Oct 1;49(10):853-866. DOI: 10.1093/abbs/gmx073.