best medical cbd oils for parkinson’s

CBD Oil for Parkinson’s Disease: Possible Treatment and Prevention (CBD Gummies, CBD Oil)

Cannabidiol, or CBD (for cannabis plants ), is a natural compound that can be found in cannabis plants . These compounds are called cannabinoids. There are many compounds in cannabis, but only a handful of them are well-known and extensively studied.

CBD does not have the psychoactive effects of Tetrahydrocannabinol, which is cannabis’s most well-known cannabinoid. However, it does have some positive effects.

Recent research suggests that CBD could reduce anxiety and pain as well as offer neuroprotective properties.

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Recent years have seen a lot of interest in potential brain and nervous system health benefits, particularly for those with neurological disorders such as Parkinson’s (PD).

Although the research is still in its infancy and has not been published, some studies have shown promise to those suffering from PD. Let’s examine how CBD could help to alleviate symptoms of this progressive neurological disorder.

CBD for Parkinson’s

CBD has not been long-term used by Parkinson’s patients. Research into the benefits of CBD only began a few decades back.

This means that research is very limited and the studies that have been conducted are often quite small. To confirm benefits, scientists and doctors must conduct larger-scale research.

Some studies have shown that CBD has some positive effects on nonmotor symptoms like anxiety, depression, and sleep disorders.

A small study of 22 people with Parkinson’s discovered that cannabis could help reduce pain. This study was done with medical marijuana that contains both CBD as well as THC.

However, animal research has shown that CBD alone can reduce pain and inflammation. These are two factors that can be problematic for people with PD.

Tremors

Uncontrolled muscle movements or medicine-related tremors can be caused by some of the most common Parkinson’s treatments. The medicine will not make the condition better, but it may make it worse.

An older, less invasive study suggested that CBD could be used to ease muscle movement.

Psychosis

Psychosis could be a complication of Parkinson’s disease. It can lead to hallucinations, delusions, and delirium. This is more common in those in the late stages of Parkinson’s disease.

This is because 50% people with PD are affected by this complication.

Although medications exist to treat Parkinson’s psychosis and other conditions, some people wonder if CBD could be of benefit.

A small 2009 study on individuals with Parkinson’s and psychotic symptoms showed that the compound reduced the severity of their symptoms. It did not cause any adverse reactions.

Sleep

Parkinson’s patients should be concerned about sleep disruptions and poor quality sleep. Vivid dreams and nightmares are common. It is also common to experience movement during sleep.

Studies found that CBD and cannabis alone may help with sleep disorders.

Quality of life

Researchers have suggested that CBD may help improve the quality of life for Parkinson’s patients. This is a significant concern for people with Parkinson’s.

One study showed that CBD usage had a positive impact on the quality of life for people with Parkinson’s disease. The results of this study were also limited and further research is required to confirm them.

Status with FDA

There are currently no FDA-approved cannabis treatments to treat Parkinson’s disease. The FDA approved Epidiolex, a CBD medication that can be used to treat epilepsy.

Researchers at the University of Colorado have used that drug to study its effects on Parkinson’s-related tremor. This is the second phase of the study.

This is still a small study with only 10 participants. To confirm or disprove what this study concludes, larger studies will be required.

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CBD to prevent Parkinson’s

Although CBD has been shown to be effective in preventing Parkinson’s disease, researchers have only studied it in animals.

The research also suggests that CBD cannot be used to treat PD once it has begun. This suggests that CBD may only serve as a preventive measure.

However, human research that looked at CBD’s ability to prevent Parkinson’s disease did not yield significant results. Further research is required to determine why CBD might be beneficial for animals’ brains, but not humans.

Keep in mind that about 60%of the dopamine-receptive brain neurons are already dead by the time a person starts to show signs of Parkinson’s. CBD is only used in clinical trials after a diagnosis has been made.

It is difficult to predict who will get Parkinson’s disease and who won’t. It is hard to know who CBD preventive measures could help.

How to Use CBD for Parkinson’s

You may be a beginner with CBD and curious about how to use it if you have Parkinson’s disease.

CBD can be purchased in these forms:

  • Tinctures and oils. These CBD forms can be taken orally (under the tongue) or sublingually. If you have trouble swallowing pills or chewing gum, this might be an option.
  • Creams and lotions CBD-infused creams and lotions can take hours to show results, but they may be helpful in treating pain and stiffness in the hands and joints.
  • Both capsules and pills. This form of CBD may cause a delay in the effects. However, it may be a good choice for those with tremors or tremors.
  • Gummies is a popular option for CBD. CBD can also be found in many other edible foods. However, the dosage may not always be as precise as it is in other forms. Edibles discreetly deliver CBD.
  • You can vape or inhale CBD oil. This route is fast and effective. Vaping can cause damage to the lung tissue and worsen symptoms such as sore throat or coughing.

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Side effects and potential risks

CBD was well tolerated in most studies. Side effects are rare and mild. These side effects include fatigue, nausea, vomiting, changes in appetite, or diarrhea.

CBD can interact with prescription or over-the-counter medication. Before you start using CBD, talk to your doctor.

CBD and the gold star treatment for Parkinson’s

There is a proven treatment for Parkinson’s Disease, but it’s not perfect.

Levodopa, the most common and effective treatment for PD, is widely used. This medication replenishes the brain’s dopamine levels.

Levodopa treats many motor symptoms associated with Parkinson’s disease. This includes muscle stiffness and tremors.

This medicine cannot treat Parkinson’s nonmotor symptoms. These symptoms can have a dramatic impact on a person’s quality of life quality. These symptoms include anxiety, depression and poor sleep quality.

Additionally, long-term use of levodopa can cause side effects such as agitation and anxiety, confusion, nausea, and nausea. You may experience a type tremor, but that is not due to PD.

CBD seems to be more effective in treating nonmotor and side effects of cannabis than it is for motor problems. One study involving more than 200 people showed that cannabis use had a high effect on nonmotor symptoms. This study did not include CBD and THC alone.

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The bottom line

CBD has some promise for Parkinson’s patients. CBD may be able to ease the symptoms of Parkinson’s disease. It might also help with side effects of other treatments.

It is important to keep in mind that these studies are often very small. Before CBD is given the green light by many doctors and FDA, it will require larger, more detailed studies. The results are encouraging, and there is reason to be hopeful for future research.

Doctors are increasingly open to CBD as a complement to treatment. Talk to your doctor about the symptoms you are experiencing and how CBD can help.

CBD Oil For Parkinson's Disease: Best Products, Safety, & Dosage

Parkinson’s disease is an incurable neurodegenerative disorder.

Evidence suggests CBD may be able to provide relief from some of the most irritating symptoms.

Here’s how it works.

Article By

Parkinson’s disease is the second most common neurodegenerative disorder, behind Alzheimer’s disease. The condition affects an estimated 10 million people worldwide — primarily men over the age of 60.

Parkinson’s disease is characterized by muscle tremors, stiffness, and issues with movement.

Although there is no cure for Parkinson’s disease, the progression of the disease can be delayed with carefully orchestrated changes to the diet, lifestyle habits, and the use of medications and supplements.

New research suggests CBD oil may offer powerful support for common side-effects of Parkinson’s disease.

Here, we’ll discuss the best CBD oils for Parkinson’s disease, what dosage to use, and what side-effects to watch out for.

MEDICALLY REVIEWED BY

Updated on June 05, 2021

Table of Contents
Recommended products
$49 – $229
Royal CBD
Royal CBD Oil 30 mL

5 / 5

Total CBD: 250 – 2500 mg
Potency: 8.3 – 83.3 mg/mL
Cost per mg CBD: $0.09 – $0.20
Extract Type: Full-spectrum
THC Content: <0.3%

What Are The Benefits Of CBD For Parkinson’s Disease?

There is no cure for Parkinson’s disease — treatment is aimed at slowing the progression of the disease and managing uncomfortable symptoms as they appear in order to improve quality of life.

Parkinson’s patients use CBD supplements to help alleviate symptoms such as depression, anxiety, muscle tremors, and some of the other complications associated with the condition.

There’s also some indication that CBD can be used to slow the progression of the disease and improve underlying factors including brain inflammation and dopamine regulation.

The potential benefits CBD oil for Parkinson’s Disease Include:

  • Reduces brain inflammation
  • Alleviates muscle tremors
  • Supports depression & mood disorders
  • Improves sleep quality & duration
  • May support dopamine production
  • Supports healthy microbiome diversity

1. Reduces Brain Inflammation

Inflammation in the brain is closely associated with Parkinson’s disease [6]. As damage occurs in the dopamine-producing neurons in the brain, inflammation gradually worsens. As inflammation intensifies, it speeds up the neurodegenerative processes in the brain — aggravating the condition.

Inflammation may or may not be an underlying cause for Parkinson’s, we still don’t know for sure. What we do know, however, is that this form of inflammation isn’t making the condition any better. Therefore one of the primary treatments for this condition is to try and lower inflammation in the brain. This helps the neurons recover, and may slow the progression of the disorder.

CBD is especially proficient at addressing inflammation in the brain as it mediates several key pathways involved with the inflammatory process [7].

Inflammation in the brain is thought to be one of the main perpetuating factors of Parkinson’s disease [6].

2. May Reduce Muscle Tremors

Muscle tremors are one of the primary symptoms of Parkinson’s disease. It has a major impact on the quality of life of those affected.

CBD has shown promise in early research to variably improve muscle tremors in mice with Parkinson’s disease [8], and similar potential neurodegenerative disorders like multiple sclerosis (MS) [9], and Huntington’s disease [10] — all worth further clinical investigation.

3. May Alleviate Depression

Studies suggest that 45% of people with Parkinson’s disease also suffer from depression [2, 3].

One of the most important benefits of CBD is in the potential relief of depression. The main mechanism CBD is thought to relieve symptoms of depression is through its ability to reduce neuroinflammation [17] — a condition that’s also present with many Parkinson’s disease patients and is likely a contributor to so many Parkinson’s patients also suffer from depression.

4. Improves Sleep Quality and Onset

Sleep disorders are a common side-effect of Parkinson’s disease [13].

There are several reasons for this, including:

  • Involuntary muscle movements sleeping
  • Muscle contractions in the early hours of the morning
  • Painful cramps at night
  • Tremor and difficulty turning in bed
  • Medication side-effects (such as levodopa, other dopamine agonists and antidepressants)
  • Hallucinations
  • Vivid dreams

CBD is well-known for its mild sedative benefits [11]. CBD improves both sleep quality and quantity in a series of clinical trials [12].

Other cannabinoids, including CBG (cannabigerol), are thought to offer muscle relaxant properties — adding layers of support for some of the primary causes of insomnia among Parkinson’s disease [14].

5. Supports Dopamine Production

The primary cause of symptoms with Parkinson’s disease is low dopamine production in the brain. Therefore, one of the most important targets of effective treatment is on the dopamine-producing neurons in the brain.

CBD has been shown — in at least one preclinical study — to improve dopamine production [15]. It works through a newly discovered receptor known as the GPR6 receptors located in the same region where dopamine is manufactured [16].

This is a new and very important discovery. New research is currently underway to understand these effects in more detail and better discern the role CBD could possibly play in the role of Parkinson’s management.

If these findings are shown to be therapeutically relevant through future research, we can expect to see CBD become a primary treatment option for Parkinson’s disease. At this point, the research is inconclusive.

What’s the Recommended Dose of CBD?

There aren’t enough clinical studies to highlight a specific dosage range for Parkinson’s disease. However, there’s a lot of research on the use of CBD use for other neurodegenerative diseases, such as multiple sclerosis.

Heavy doses of CBD are usually required to produce benefits for these conditions.

We recommend starting at the low-strength dose as highlighted in the chart below and build up over time to the heavy dose based on your weight. To find your dose, use the CBD oil dosage calculator below.

For Parkinson’s disease, you should aim to use the supplement long-term.

Recommended Strength For Parkinson’s Disease: Heavy Strength

CBD Oil Dosage Calculator

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What is Parkinson’s Disease (PD)?

Parkinson’s disease (PD) is a neurodegenerative disorder affecting the part of the brain responsible for manufacturing dopamine. Dopamine is a neurotransmitter associated with things such as mood, hormone balance, motor function, and focus or attention.

Symptoms of this condition usually appear gradually over the course of several years before and after diagnosis.

They begin with nonspecific issues like hyposmia (reduced sense of smell), sleep disorders, constipation, and obesity up to 20 years before the more characteristic muscular issues such as rigidity, tremors, and falling.

As the disease progresses, non-motor symptoms such as hallucinations, delusions, dementia, and depression can appear and worsen over the next 20 years.

Parkinson’s disease by itself isn’t considered fatal — however, some of the complications brought on by the disease are — and can also certainly be life-altering and devastating for patients and families.

A common finding in PD patients is an abundance of Lewy bodies — clusters of proteins inside the neurons that don’t break down as they should through normal enzyme reactions in the brain.

As these Lewy bodies become more abundant and build up, they kill the neurons. This type of neuron injury is also characteristic of other neurodegenerative disorders including Alzheimer’s disease (AD). The main differences are in the composition and location of the proteins.

In the case of Parkinson’s, the majority of these protein clusters are in the basal ganglia of the brainstem — specifically in the substantia nigra pars compacta neurons.

What Are The Signs & Symptoms of Parkinson’s Disease?

  1. Muscle tremors
  2. Bradykinesia
  3. Limb rigidity
  4. Mask-like face
  5. Gait and balance problems, i.e. shuffling
  6. Depression
  7. Poor focus or concentration
  8. Mood changes
  9. Apathy
  10. Constipation
  11. Excess salivation
  12. Urinary retention
  13. Sleep behavior disorders
  14. Loss of sense of smell
  15. Cognitive impairment

Dopamine & Parkinson’s Disease

The majority of symptoms associated with Parkinson’s disease result from a loss of dopamine-producing cells in the brainstem.

As the dopamine-producing neurons in the brainstem are lost, it becomes more difficult to manufacture the dopamine the brain needs to function properly. In fact, by the time characteristic muscle symptoms are clinically apparent, over 80% of the dopamine-producing neurons are gone. Without enough dopamine, symptoms like muscle tremors, lockjaw, weakness in the arms and legs, and poor balance are more frequent.

A loss of dopamine is linked with symptoms including:

  • Mood changes
  • Loss of normal muscle control
  • Hormonal changes
  • Poor libido
  • Difficulty concentrating
  • Depression

Norepinephrine & Parkinson’s Disease

Norepinephrine and epinephrine is structurally similar to dopamine and is built through the same pathway as dopamine. Therefore, epinephrine levels also suffer a decrease in production from Parkinson’s disease [1].

These neurotransmitters are major players in the sympathetic nervous system. As they start to become less abundant in the brain and blood vessels, we lose the ability to regulate autonomic functions including heart rate and blood pressure.

A loss of norepinephrine and/or epinephrine are linked with symptoms including:

  • Fatigue
  • Changes in blood pressure
  • Problems with digestion
  • Poor concentration
  • Depression

What Causes Parkinson’s Disease?

The cause for Parkinson’s disease is still unknown — however, there are a few factors that we now know contribute to the condition over time.

Older studies used to report Parkinson’s disease as being non-hereditary — meaning a disease that isn’t passed on through genes [4]. Newer studies, however, found at least two gene variants related to Parkinson’s disease [5] — LRRK2 and GBA genes, albeit rarely. Most cases by far are idiopathic.

Some factors believed to be linked with Parkinson’s disease include:

  1. Heavy metal exposure
  2. Traumatic head injuries
  3. Genetic factors
  4. Paraquat exposure (pesticide)
  5. Leaky gut syndrome
  6. Poor microbiome diversity
  7. Mitochondrial disease

The 5 Stages of Parkinson’s Disease

Stage 1

Symptoms appear but are mild in nature. They usually don’t interfere with daily activities. The most common symptoms to appear are postural changes, muscle tremors, and changes in facial expression.

Stage 2

Stage two involves an increase in the severity of symptoms discovered in stage one and the development of symptoms affecting movement. It may be more difficult to walk normally, maintain correct posture, and normal tasks begin to become difficult. Usually, people in stage two don’t require outside assistance.

Stage 3

This stage is characterized by problems with maintaining balance and difficulties with day-to-day activities such as eating, using the toilet, or getting dressed. People in stage three may need assistance, while others remain independent.

Stage 4

By stage four, symptoms have become pronounced. Standing is possible, but walking requires the support of a walker or another person. Daily activities such as eating, bathing, and moving around require assistance. People at this stage are not able to live independently.

Stage 5

This is the last stage of Parkinson’s disease progression. Patients are unable to stand or walk on their own and are usually confined to a bed or wheelchair. Hallucinations and delusions may appear during this stage. Full-time assistance is required for people in this stage of disease.

How is Parkinson’s Disease Treated?

Most of the treatments for Parkinson’s disease are aimed at managing symptoms in order to optimize a patient’s quality of life. There are several medications and supplements that improve dopamine production in the brain, but these won’t cure the condition — only reduce the severity of symptoms associated with low dopamine. The medications will also need to be readjusted over time, along with regular follow ups with a neurologist.

Treatment Options for Parkinson’s Disease and Symptoms Includes:

  • Amantadine
  • Anticholinergic drugs
  • Antidepressants (SNRIs, SSRIs, TCAs)
  • Antioxidant supplementation
  • Cardio-aerobic exercise
  • Coffee consumption
  • COMT inhibitors
  • Deep brain stimulation
  • Dopaminergic medications (MAO-B Inhibitors, amphetamines)
  • Ensure adequate, restful sleep each night
  • High fiber diets
  • L-dopa supplementation
  • Meditation/yoga/Tai-chi
  • Occupational therapy
  • Probiotic supplementation
  • Speech therapy

Key Takeaways: Can CBD Help With Parkinson’s Disease?

There’s no cure for Parkinson’s disease — most of the treatment options available, including CBD are used to slow the progression of the disease and manage symptoms to improve a patient’s quality of life.

CBD is a potentially excellent option for both — it may alleviate many of the most common side-effects of the conditions (insomnia, depression, anxiety, muscle tremors) and perhaps may slow the progression of Parkinson’s, although more clinical research is needed to demonstrate this.

It’s important to consult with your doctor before using CBD to ensure it won’t have any negative interactions with the medications you’re taking. Patients with Parkinson’s disease will need multifaceted treatment and regular follow ups with their neurologist to readjust medication as needed.

Anecdotally, Most Parkinson’s patients use a high dose of CBD for long periods of time.

For maximum benefits, opt for a high-potency full-spectrum CBD oil to take advantage of other cannabinoids such as CBG that have their own set of benefits to offer Parkinson’s symptoms.

We also recommend using only high-quality CBD and hemp oils. Low-quality products may be contaminated with heavy metals or pesticides that can actually make symptoms even worse.

Always do your research before buying CBD to make sure the companies you’re buying from use high-quality hemp, free from contaminants.