can i take cbd oil with topamax for migraines

CBD Drug Interactions – Mixing Cannabidiol and Medications

Are you worried about potential CBD-drug interactions? In this article, we explain the mechanism behind drug metabolism and how CBD may interfere with it.

The range of therapeutic properties offered by CBD (cannabidiol) has spurred its popularity in recent years. This natural compound is known to relieve a host of symptoms, allowing for safer and more effective management of different health conditions.

And unlike THC (tetrahydrocannabinol), CBD is non-intoxicating, so it won’t get you high.

CBD can assist in the treatment of anxiety disorders and depression, inflammation and pain, neurodegeneration, seizure disorders, sleep deprivation, metabolic conditions, neuropathy, migraines, inflammatory bowel disease, and more.

Considering CBD has so many potential health benefits, you may start wondering if it can interact with certain medications used to address the same symptoms — and whether you should or shouldn’t take these drugs with CBD.

Below you’ll find the dos and don’ts of using CBD along with medications.

Let’s start with the don’ts.

What Drugs Should Not Be Taken with CBD

Studies from the Indiana University Department of Medicine have provided a list of pharmaceutical drugs and medications which shouldn’t be taken with CBD.

The list below covers all groups of drugs that can negatively interact with CBD oil.

  • Angiotension II Blockers
  • Antiarrhythmics
  • Antibiotics
  • Antidepressants
  • Anticonvulsants / Anti-Seizure Medications
  • Antihistamines
  • Antipsychotics
  • Anesthetics
  • Beta-Blockers
  • Benzodiazepines
  • Calcium Channel Blockers
  • HIV Antivirals
  • HMG CoA Reductase Inhibitors (Statins)
  • Immune Modulators
  • Non-Steroidal Anti-Inflammatory Drugs
  • Oral Hypoglycemic Agents
  • Proton-Pump Inhibitors (PPIs)
  • Prokinetics
  • Steroids and Corticosteroids
  • Sulfonylureas

There’s also a group of drugs called “prodrugs” that first need to be processed into their therapeutic compounds instead of being therapeutic compounds on their own. In plain English, the inactive compound is consumed, and once in the body, it turns into the active compound.

If this mechanism is dependant on the CYP450 system (more on that later), a drug interaction can lead to insufficient concentrations of the therapeutic agent in the bloodstream — reducing its potency.

CBD Interaction with Drugs & Medications

This section covers the most common interactions between CBD and medications. If you take any of the substances listed below, make sure to consult your doctor before buying CBD oil.

CBD and Ibuprofen Interaction

Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), meaning it can produce similar benefits to CBD in terms of inflammation and pain relief. Previously we’ve mentioned that NSAIDs interact with CBD, which may raise concerns about potential negative interactions between CBD oil and Ibuprofen.

According to a study from the Journal of Neurology Research, there have been no reported interactions between CBD and ibuprofen, although it doesn’t mean they do not exist. Health experts suggest that potential interactions may be dosage-dependent. If a certain dosage threshold is breached, CBD and NSAIDs like Ibuprofen can lead to unforeseen and potentially severe nervous system pathology.

CBD and Adderall Interaction

A 2020 study found that higher doses of medical cannabis led to a decreased use of ADHD medication in adults. Products containing a higher concentration of CBD were linked to lower ADHD scores. This means that CBD can interact with ADHD meds, decreasing their efficacy while providing more pronounced benefits. The potential side effects of interactions between CBD and Adderall may lead to decreased appetite.

CBD and Lamictal Interaction

Using medical cannabis and Lamictal may increase side effects such as dizziness, confusion, drowsiness, and difficulty concentrating. Elderly consumers may also experience impairment in judgment. That being said, none of these side effects were proven to result from CBD use per se. When it comes to interactions between CBD and Lamictal, it can make the medication more or less effective, depending on the dosage.

CBD Oil and Antibiotics

There is no known interaction between CBD and antibiotics, although these interactions may occur if an antibiotic is metabolized through the cytochrome P450 enzyme system. Some studies indicate that taking CBD and antibiotics together may amplify the effects of one another without any negative side effects. However, more research is needed to confirm these findings on a larger scale.

CBD Oil and Omeprazole

CBD can inhibit the enzymes that are targeted by omeprazole and other Proton Pump Inhibitors (PPIs). Taking CBD with certain heartburn medications can increase the risk of diarrhea.

CBD and Thyroid Medications

Some people report mild nausea when taking CBD oil together with their thyroid medications. Since both substances are processed by the CYP450 enzyme system, taking CBD with a thyroid medication may cause hyperthyroidism because more thyroxine would be secreted than the body could metabolize.

CBD and Lisinopril

CBD can temporarily lower blood pressure, so taking it alongside medications like Lisinopril might reduce it even more, making you feel lethargic and weak. Always consult your doctor before adding CBD to your routine if you use anti-hypertension meds.

CBD and Prednisone

Since both CBD and corticosteroids are potent inhibitors of the CYP450 enzyme system, concomitant use may increase the risk of systemic side effects from corticosteroid use due to decreased glucocorticoid clearance. Corticosteroids like prednisolone and hydrocortisone should never be taken with CBD.

How Drugs Interact: Understanding Drug Metabolism

Metabolism can refer to how your body uses energy for weight management, or the way drugs are metabolized in your body.

The former is known as the basal metabolic rate, or in simple terms, the number of calories a person needs to maintain healthy body functions while at rest.

The latter is very different from the basal metabolic rate. Drug metabolism refers to how a substance is processed and used by the body — with the majority of this processing happening in the liver.

Scientists call it the ‘first-pass effect’ or ‘first-pass metabolism.’

Using straightforward terms, when you take a medication, it is broken down in the liver into its active compounds so that the body can use them. Just like carbohydrates are broken down into sugars, fats into triglycerides, and proteins into amino acids — drugs break down into their individual ingredients.

From there, they are controlled by specific enzymes, which transform these compounds into metabolites. These metabolites then influence different processes in your body and are flushed with urine once used up.

How Is CBD Metabolized?

Drug metabolism determines the rate at which the body processes medications and other therapeutic compounds into their individual metabolites and how long they can stay in your system.

When you take CBD in the form of an oil, capsule, or gummy, it has to pass through your gut, where it is released into the bloodstream. From then, they travel through the bloodstream to the liver, where it absorbs through the hepatic portal. The liver breaks CBD down into its metabolites using enzymes, after which it can circulate throughout the body in the bloodstream again.

What Is the Cytochrome P450 System?

Aside from breaking compounds down into metabolites, the liver also detoxifies and excretes foreign substances and other types of toxic compounds. This can happen through a system of enzymes referred to as the Cytochrome P450 (CYP450). These enzymes contain heme as a cofactor to convert cannabinoids into more water-soluble molecules, increasing their absorption and efficacy.

Researchers estimate that the CYP450 system is responsible for metabolizing 60% of any drugs out there. And interestingly, doctors and pharmacists use this system to understand, evaluate, and predict the benefits of the drug and potential side effects based on their dosages.

However, certain compounds have the ability to compromise the CYP system’s functioning, negatively affecting the metabolism of certain medications. Once these interactions occur, the drugs can be metabolized faster or slower than normal.

CBD And the Cytochrome P450 System

As mentioned earlier, CBD can interact directly with the CYP450 system in the liver. According to preclinical studies, CBD binds to the site where the enzyme activity occurs, competing with other compounds and thus preventing this system from breaking down other substances.

This inhibitory effect on the CYP450 enzymes mainly depends on how much CBD a person takes, their unique physiology, and the type of CBD used (e.g., full-spectrum CBD vs. CBD isolate). The dosage determines the strength used by the CBD to bind to the active site of the metabolic enzymes. The tighter the bond, the more competitive inhibition.

Contraindications for Taking CBD with Medications

The mechanism behind CBD’s health benefits proves that it’s not a biologically inert compound. Instead, the pharmacokinetics and pharmacodynamics of CBD are complex and similar to any other medication. Therefore, it has the potential to compromise the metabolism of certain medications.

Any therapeutic substance that relies on the CYP450 system can be potentially affected by CBD. A common indicator for such interaction is when your medication has a grapefruit warning on the bottle. However, this is by no means a solid point of reference, and you should always check with your doctor and pharmacist before taking the two compounds together.

Why You Should Always Consult Your Doctor First

The list of drugs that we’ve mentioned above is by no means definite and doesn’t include all the pharmaceutical substances that may interact with CBD. Similarly, not all the medication from these categories will necessarily cause an interaction — as is the case for antibiotics and Ibuprofen.

A consultation with a doctor experienced in CBD and cannabis use can help you establish the right routine for your medications and supplements to avoid potentially negative interactions. Some compounds work synergistically with CBD, so asking your doctor can help you maximize the effect of your treatment.

Not to mention that the doctor can guide you on finding the optimal dosage for yourself.

Key Takeaways on CBD Drug Interactions

The safety profile of CBD has been acknowledged by major health agencies, such as the World Health Organization (WHO), showing that it’s well-tolerated by animals and humans and rarely produces any dangerous side effects.

CBD also has a profound impact on an array of systems, which explains its therapeutic versatility. That being said, this versatility is also the reason why CBD interacts with so many prescription meds and over-the-counter (OTC) PRODUCTS.

Again, if you’re not sure if CBD will interact with the medication that you might be taking, a consultation with a health professional will not harm — unlike trying to figure out these interactions on your own.

Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

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Topiramate (Topamax) Review For Migraine

Topamax is a billion dollar blockbuster drug used to help prevent migraine and epilepsy. It’s one of the most commonly prescribed migraine preventative drugs in the USA. So what is Topamax (also known by its generic name topiramate)?

It’s an antiepileptic medicine also known as an anticonvulsant. Anticonvulsants are a class of drugs which were originally designed to prevent seizures in those with epilepsy.

Topamax is the brand name developed by a division of Johnson & Johnson which held a patent to their formulation when approved in 1996. Once the patent expired a cheaper generic option became available in the form of topiramate. At the time of its approval in 2009, there were over 17 different generic manufacturers. [i]

Brand names for topiramate

Topamax, Topamax Sprinkle, Qudexy XR, Topiragen, Trokendi XR

Qudexy XR and Trokendi XR are both relatively new extended release formulations of topiramate.

It is available in the following formats:

  • Tablets: 25 to 200 mg
  • Sprinkle capsules: 15 and 25 mg
  • Capsule (Extended Release): 25 to 200 mg

Do I need a prescription for Topamax (topiramate)?

How does it work?

The short answer is “we’re not sure actually”.

Topiramate was originally developed for epilepsy. [ii] Those with epilepsy started noticing an improvement in their migraine condition in several case studies and from there a trial was conducted to test migraine patients specifically. It was not designed with migraine in mind but it is arguably an effective treatment for the prevention of migraine.

Epilepsy and migraine share a number of biological and clinical features in common. [ii] Perhaps not surprising to find that anticonvulsant medications may have a therapeutic benefit for both indications.

Scientific studies suggest topiramate reduces brain hyperexcitability, which is thought to provoke migraine attacks in those susceptible.

The ways in which a drug works is often referred to in clinical papers as its mechanism of action. Topiramate’s mechanism of action may involve[iii]:

  1. Blocking voltage-dependent sodium channels
  2. Augmenting the activity of the neurotransmitter gamma-aminobutyrate
  3. Antagonizing the AMPA/kainite subtype of the glutamate receptor
  4. Inhibiting the carbonic anhydrase enzyme

What does all that mean in English?

It essentially describes how Topamax blocks certain neurotransmitters or pathways in the brain as well as changing or altering how they behave.

How effective is Topamax (topiramate)?

The short answer – it’s considered to be an effective option for migraine prevention.

Both US and European authorities have given Topamax or topiramate what they term ‘Grade A’. Grade A is the highest rating a treatment can receive. The grade is a reflection of the quality of research evidence and the efficacy of its results according to the clinical evidence.

When several clinical research studies are collectively reviewed to analyze and evaluate research it is called a systematic review. Often meta-analysis is used to summarise the results of these studies.

Fortunately this work has been conducted on topiramate for the prevention of migraine attacks in adults. A nonprofit called The Cochrane Collaboration reviewed 17 studies and found that patients did reduce their frequency of migraine headaches per month versus placebo. They also found that patients were around twice as likely to reduce the number of attacks by 50% or more with topiramate than with placebo.[iv]

The scientific conclusion for this systematic review was that topiramate at a 100mg/day dosage can be effective and reasonably well-tolerated in adult patients.

Get A List Of Proven Migraine Preventative Treatments. Free for a limited time.

Side Effects

The same review from Cochrane acknowledged that whilst there were good results with topiramate, the occurrence of side effects were common but generally mild.[iv]

Topiramate can cause birth defects and is not suitable for certain people. View the following section on ‘Safety Profile’ for more details.

What side effects are considered common? Anything above a 10% incidence rate is considered to be ‘very common’ whilst anything with a 1%-10% incidence rate is considered ‘common’.[v] See below table for side effects or adverse effects.

Notice how the side effects are more likely to increase as the dose increases from 50 mg to 100 mg. Highlighted numbers are side effects which are considered to be ‘very common’.

Table reference: Topamax (topiramate) side effects [iii]

Some symptoms you might not recognize are defined below:

  • Hypoesthesia – reduced sense of touch or numbness
  • Dyspepsia – pain or uncomfortable sensation in the gut including reflux
  • Gastroenteritis – commonly termed ‘gastro’. An infection upsets the stomach
  • Psychomotor slowing- slowing of thought and physical activity such as movement and/or speech

Please note this is not a full list of potential side effects. There may be other serious side effects that you may be vulnerable to which is why you should speak to your doctor if considering whether topiramate may be appropriate.

Personal experience: As someone who used Topamax for several years I noticed several symptoms myself when taking a dose anywhere between 25 mg to 100 mg per day.

The first was the tingling sensation. This happened almost immediately after my first dose which I wasn’t prepared for. After speaking with my doctor and confirming everything was ok, I continued with the treatment and within the first week those symptoms had faded entirely.

The second common symptom was the sluggishness I felt in the morning. It was more difficult to get out of bed in the morning. I still felt tired, like my sleep wasn’t nearly as restful.

I would not call myself a morning person generally, but this side effect encouraged anyone around me to tip-toe until at least a half hour after I’d woken up.

The final two noticeable side effects I experienced was moodiness and cognition impairment including difficulty with memory.

‘Dopamax’ is a nickname coined by some which describes how you might feel on Topamax (or topiramate). You can see above the prevalence of this side effect. For those who experience it, it can become more obvious over time. I had been on Topamax for years… but towards the end I experienced around a 30% reduction in cognition. This was a noticeable impact on the speed, sharpness and clarity of thought I would have without Topamax.

Most noticeably I’d have difficulty remembering the names of certain things and to some degree, my memory of recent events was affected.

The most bothersome side effect were the mood changes. I became more easily agitated and grumpy. I had a temper on Topamax which I didn’t have otherwise.

As my condition improved due to Topamax and other preventative strategies I gradually weaned off Topamax. The side effects also faded.

Fortunately I did not have any serious side effects which would stop me using Topamax long term (several years). Some of these are listed in the next section below. None of which are not common enough to be mentioned in the above table.

If serious side effects are common the drug is not likely to be approved by regulatory authorities like the FDA.

Safety

Topiramate when prescribed by a doctor who takes into account your full medical history, current medications and health profile are considered a safe and approved treatment by the FDA and other regulatory medical bodies around the world.

However there are important warnings and precautions that come along with this treatment.

For example, never stop suddenly taking the medication. This is a medication that requires a gradual withdrawal with staged reductions in dose. If the medication is suddenly halted then seizures may occur in those who do not normally experience them.

Topiramate also has several more uncommon but serious side effects:

  • Eye problems, including acute Myopia, which may involve difficulty seeing clearly as well as a build-up of fluid in the eye (which can lead to blindness if not treated).
  • Hyperammonemia which refers to high levels of ammonia in the blood.
  • Metabolic acidosis which is an elevated level of acid in the blood.
  • Encephalopathy which refers to brain disease, damage or other issues
  • Suicidal behavior or ideation can be increased in patients taking Topamax.
  • Fetal toxicity. Topamax can harm or cause birth defects in the unborn baby in a pregnant woman. It is also not appropriate for a nursing mother or mother who plans to become pregnant whilst using Topamax.
  • Kidney stones can be caused by Topamax. Doctors often advise patients to drink plenty of water throughout the day to help prevent kidney complications.

Major Drug Interactions

Topiramate like many other medications interacts with other medicines and can have dangerous consequences. It is important to ensure your doctor has a full list of everything you are currently taking.

Interactions of Topamax (topiramate) include:

  • Other antiepileptic drugs
  • Central Nervous System Depressants
  • Oral contraceptives
  • Lithium
  • Carbonic Anhydrase Inhibitors (eg. zonisamide or acetazolamide)
  • Hydrochlorothiazide (HCTZ)
  • Pioglitazone
  • Amitriptyline

People who should not use Topamax or topiramate:

  • Women who are pregnant, planning to get pregnant or nursing mothers.
  • Children under the age of 12 have not been evaluated in the efficacy or effectiveness of Topamax for migraine prevention. On a subjective note: I’d be asking the doctor what impact Topamax or topiramate could have on a developing brain. Personally, it’s not something I’m comfortable considering as a first line option for a child with migraine.
  • Patients with renal impairment (renal failure) or undergoing hemodialysis which is a type of dialysis to remove waste products from the blood.

Dosage

Ranges from 25 mg to 200 mg per day.

Topiramate is one of those treatments where it is very appropriate to ‘Go Slow, Start Low’. It is often initiated at a dose of 25 mg per day with a gradual increase to your maximum tolerated dose.

Your maximum tolerated dose is basically how much you can take without the side effects or adverse events becoming worse than any benefit derived from the treatment.

In clinical trials a maximum dose of 200mg has been researched frequently. Interestingly, in epilepsy, studies have researched dosages up to 400mg.

In the US generic topiramate is covered by most Medicare and insurance plans. A 60 tablet (a one month supply) of 50mg can be purchased for as low as $10-15 per pack.

In the UK, a 60 pack of 50mg topiramate retails at £31.69.

In Australia, Topamax is listed on the national PBS scheme and is available for $25.02 per pack of 60 tablets. For the generic version, topiramate, the same quantity can be bought for $14.99.

In Canada, the 120 pack of 50mg is available for $288 USD. The generic is still $114.90 USD.

Important to remember for all medications

Overdosing is when you take more than your prescribed dose. Never overdose. If you believe an overdose has occurred visit the emergency department of your hospital. Take the medication container and pack with you even if it’s empty. Better to be safe than sorry.

The medication prescribed to you is only for you. Never share it with others who you believe have a similar condition. Your specific treatment may cause serious issues with others who do not share the same health profile, history or who are using other medications.

If you are having an operation or dental treatment, tell the practitioner what treatments you are currently taking.

Out of date medications should be disposed and can have unintended consequences if taken.

If you have questions about your treatment ask your pharmacist or doctor.

Never change or stop your treatment or dosage without first consulting your doctor.

User reviews:

Most of what we’ve heard so far has been based on what is available in clinical trials or medical reviews. Seeing how patients themselves rate topiramate, especially when compared to everything else they’ve tried, can be very interesting.

Below are effectiveness results from 3 separate sources.

Survey 1 from Curetogether had a survey that numbered 718 participants (n = 718). 11% found a major improvement with topiramate. 27%[vi]

Interestingly, a survey with 375 participants (n = 375) from Patients Like Me found different results.

35% of patients had a major improvement, 30% a moderate improvement and 18% a slight improvement. 27% had either no improvement or couldn’t tell. Patients were not able to report whether they believe topiramate had worsened their condition or not. [vii]

The final source is Drugs.com where 293 participants (n = 293) evaluated their treatment. Topiramate scored an overall 6.2 out of a possible 10. The best review with enough samples was 8 out of 10.[viii]

User side effects:

From the user reviews, 48% of patients report (n = 1236) severe or moderate side effects with topiramate. The most common side effect being weight loss (n = 94) followed by brain fog (n = 66), memory problems (n = 56) hands tingling (n = 54) and word fishing (n= 52).

Conclusion

There is a general agreement amongst users that at least 30% experience a moderate improvement with a further 11% to 35% experiencing major improvement depending on the source.

This could be considered similar to the systematic review of clinical research where twice as many patients report a 50% headache frequency reduction versus placebo.

Side effects from topiramate are common. Some might consider weight loss a welcomed side effect. Other side effects like tingling or word fishing might not be considered severe but some people may not tolerate memory problems or brain fog. Everyone is unique in the side effects they experience. Some may not experience any, whilst others may find them intolerable.

If you can tolerate the side effects, then topiramate may be considered an effective and useful treatment for migraine.

What about you? Has your experience with Topamax (topiramate) been positive or negative overall?

Get a list of the top proven preventative migraine treatments according to guideline recommendations from the US and Europe.

Article References

[i] Gever, J. Generic Topiramate Wins FDA Approval. MEdPage Today. April, 2009. Accessed 29 June 2017 https://www.medpagetoday.com/productalert/prescriptions/13568

[ii] Rothrock, J. F. (2012), Topiramate for Migraine Prevention: An Update. Headache: The Journal of Head and Face Pain, 52: 859–860. doi:10.1111/j.1526-4610.2012.02161.x

ii Rothrock, J. F. (2012), Topiramate for Migraine Prevention: An Update. Headache: The Journal of Head and Face Pain, 52: 859–860. doi:10.1111/j.1526-4610.2012.02161.x

[iii] Topamax Prescribing Information USA

[iv] Linde M, Mulleners WM, Chronicle EP, McCrory DC. Topiramate for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD010610. DOI: 10.1002/14651858.CD010610

[v] Collins, S. How are the words ‘rare’ and ‘common’ defined for side effects? I-base, April 2009. Accessed 29 June 2017 http://i-base.info/qa/812

[vi] CureTogether 2017, Accessed 30 June 2017 < http://curetogether.com/migraine/treatments/>

[vii] PatientsLikeMe 2017, Accessed 30 June 2017 <https://www.patientslikeme.com/treatments/show/1778#overview>

[viii] Drugs.com n.d., Accessed 30 June 2017 <https://www.drugs.com/condition/migraine-prophylaxis.html>

About The Author

Carl Cincinnato

Carl stopped taking his health for granted at an early age due to migraine. He has had migraine for 26 years. Over this time health has become central throughout his life and work. Today, he works with charities, foundations, and organizations to help lift the global burden of migraine including Headache Australia, the Brain Foundation, the Coalition of Headache and Migraine Patients, and the European Migraine and Headache Alliance. He is a member of the International Headache Society, he acts on several advisory boards and he also is the author of MigrainePal and co-host for the Migraine World Summit. Carl is a public and passionate patient advocate for migraine. He has spoken nationally and internationally about migraine and the need to increase research funding, reduce stigma, increase patient support and education. He has been featured in national TV, print and radio stations.

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156 Comments

Hi I’m on 50mg and I want off myself I hate it I’m telling my doctor tomorrow was it hard coming off and if so what are something I need to know to help me

    on October 19, 2019 at 7:01 am

You need to wean off slowly Adalia. Sudden withdrawal from a full dose without medical advice can cause side effects in some people.

Dopamax, says it all! Love it, that is the perfect name for this nightmare of a creation they are trying to pass off as treatment for migraines!

    on March 8, 2020 at 4:14 pm

Thank you for sharing Nicole. That sounds like a good suggestion from the doctor. Hopefully you get good results from the new treatment with minimal side effects. Good luck!

    on October 25, 2020 at 5:53 am

Thank you for sharing Adele.

    on December 24, 2019 at 6:19 am

Hi Karina, everyone is different and responds differently. But for me, it was only when I did everything that was helping me and took my prescribed preventives did I get better. From a non-prescription perspective, I took a number of supplements (magnesium, CoQ10, riboflavin, melatonin were the major ones). I also worked on my sleep, exercise, meditation (stress management), hydration, self-education and understanding and kept a daily diary.

Very good, informative article. I think any psychotropic-acting drug’s side effects are underestimated by patients. You have to ask the family. (intoxication anosognosia, Peter Breggin). Also I think such drug’s trials are easily biased to serve industrial interests. Some bad practices are: Denying access to the complete data of trials form researchers. Bad results of placebo from withdrawal effects. Patients getting out of trials are not counted. Suicides are masked. Ghost writing of studies. Corruption of papers, universities, professors. (source Pharmageddon, by David Healy). Thank you for sharing.

Topamax is an anticonvulsant drug approved for the treatment of seizures (epilepsy) in adults and children. It can be used alone, or in combination with other anticonvulsants. It is also approved for use in preventing migraine headaches in adults.
While not approved by the FDA for other illnesses, Topamax has been tried and studied in the treatment of tremors, nerve pain, cluster headaches, eating disorders, alcohol dependence, and bipolar disorder (also known as manic-depression). http://www.namihelps.org Topamax/PDF.

Does Topamax really treat so many disparate conditions that doctors prescribe it for everything, even when it is not FDA approved for these conditions? I must add that Topamax is one of the most dangerous drugs in the prescription market today. … Evidence is also accumulating that Topamax can cause brain damage! http://www.hormonesmatter.com/topamax-drug-nine-lives/

My question is do you treat people with depression with meds that can cause depression and is it like treating someone with a flu vaccine cause your treating it with a live virus? Topamax was prescribed for me for depression, anxiety, and headaches. Whenever I start a new Pharmacia drug that I know nothing about I often write down my side effects. But with Topamax it went a lot deeper than I attended to. Here are some of the side effects from their website:
• Abdominal or stomach pain
• fever, chills, or sore throat
• lessening of sensations or perception
• loss of appetite
• mood or mental changes, including aggression, agitation, apathy, irritability, and mental depression
• red, irritated, or bleeding gums
• weight loss
Back to the amount of money made from Topamax and why it is so ready for prescription. Even though being approved by the FDA only for seizures (epilepsy) and preventing migraine headaches in adults and may have been approved for weight loss.There are dangerous side effects caused by prescribing Topamax for other ailments.

Why would you take an epilepsy seizure drug for pain? The same reason you’ll take an antipsychotic for the blues and an antidepressant for knee pain: good consumer marketing. — But it is still the darling of military and civilian doctors for unapproved pain and migraine. Topamax also has the distinction of looting $51 million from Medicaid last year despite a generic existing.

All seizure drugs increase the risk of suicidal thoughts and behaviors according to their mandated labels. An April article in JAMA found seizure drugs linked to 26 suicides, 801 attempted suicides, and 41 violent deaths in just five years. But yet I was prescribed one of them.

Also to add to it seizure drugs can make you lose your memory and your hair, say posters on the drug rating site askapatient.com

And yet there is so much money to be made off the suffering of patients, my next question is how the dr. will react to my side effects and wanting to discontinue use? Will he say that’s a normal reaction and it will go away with time and continue treatment. I can see why he would suggest that cause after the two week mark I’m supposed to take 4 pills an hour before bed. Increase of dose is an increase in prescription equals increase in the wallets. But I have a hard time taking something that has not been approved by the FDA and especially because it’s been on the list of top15 dangerous prescription drugs.
My notable side effects from Topamax:
• Numbness and tingled fingertips which prevent me to sleep, this was one the worse withdrawals symptoms I went through when i went cold turkey off of suboxone.
• Agitated and irritable and sometime short fused
• Watery eyes
• Foggy head, problems with memory; 1985 i was given Ritalin and continued all through college
• Dry mouth and feeling dehydrated and somewhat lethargic
• My so called migraine moved to behind my left temple. I never had a problem with migraines it was caused by the lack of sleep recently. I took Depakote in the past for anger not for migraines.
• Food and drinks taste weird
• Lack of appetite
• Abdominal discomfort
These are the side effects so far after day one on Topamax will continue tomorrow and as the day progressed some got added.

Again a reminder the only reason why I’m writing this is to keep my fingertips busy to avoid trying to chew them off. But my research only dove into the treating people with depression with Topamax and the adverse effects. I didn’t get into the dangers it has affected most in females especially pregnant females. But from my research consensus is that Topamax does help with migraines but on the other hand at times does nothing or even of reports of worsen.
Oct 24/17 I took 50mg of Topamax at around 12am I was supposed to take 100mg but again I have problem taking something I know nothing about. I did fall asleep but not for long only for a few hours as I woke up with numbness and tingly fingertips which in the pass was one of my worse symptoms that prevented me from sleeping after going cold turkey from suboxone after 7yrs of taking. It usual takes at least 4-5 hours for that restless feeling to go away in my fingertips to finally fall back asleep but if you think about it I just wasted my day.
I thought it was over around 10:45pm my entire body started over heating despite having a fan on me. I couldn’t get comfortable as I’m stripping down to my boxers. I also had immense pressure behind both eyes and that’s when the sharp abdominal pains started and lasted for some time. So what am I to do? I wanted this to end! As I lay in bed trying to get comfortable I look over as that bottle of Topamax stares at me. So I took 50mg hoping to get some relief even if it only for a few hours, but I have a feeling that my body is going to reject it like it did the night before. After taking it and 2 hours later with no effect, I took another 50mg in actuality what I am prescribed. Within a restless hour I fell asleep, but only to wake up again feeling some very familiar symptoms. I felt like I was going through some of the horrors of opiate withdrawal. My back felt like it was sunburnt and tingly, my body ached, and to add on the side effects from earlier. Again after a few restless hours it subsided and I was able to fall asleep but I wasted my day. I have so much pressure behind my eyes and basically my whole head which is making me miserable. This is only from two days of taking this wonder drug and supposedly in two weeks an increase of dosage like a person whom is tolerant to their pain meds.

So is this drug being treated like a person who is prescribed or addicted to painkillers? People on painkillers and most opiate addicts achieve a tolerance where it has no more effect on them and have to up they’re intake. I personally spending much of my life in the restaurant business and witnessing firsthand the cycle of drug’s especially painkillers and its high-end price tag. Topamax is very similar to opiate painkillers when dealing with dopamine to which they both affect GABA, what is GABA? Webmd.com says states; GABA is a neurotransmitter that blocks impulses between nerve cells in the brain. Low levels of GABA may be linked to: Anxiety or mood disorders. Epilepsy. Chronic pain.

My question is why dr.’s increase the dosage of Topamax as weeks goes on as if we build a tolerance to the drug and the healthy price tag that comes with Topamax. It’s not easy finding that answer, but what I’m finding is the misuse for the drug. This justifies my beliefs on the concern about the money made and not the sanity of the patients prescribed.