Can You Take Ibuprofen With CBD Gummies

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Can I take CBD and Ibuprofen together? If you’ve ever asked this question, here’s the answer you’re looking for. Products containing cannabidiol (CBD) are very popular, promising relief from a wide range of maladies. But if you are considering taking a product containing CBD, be aware that if you are taking any other prescription or over-the-counter medications, supplements, or herbal products, CBD can interact with them and cause unexpected …

Can I Take CBD and Ibuprofen Together?

A few years ago, painkillers were the only solution against everyday pains, such as headaches, back pain, etc. Then, CBD came along, and people turned towards this holistic pain relief method.

However, some people are still smitten by the idea of using painkillers but also want to give natural approaches a try. If you can relate, you might have asked: can I take CBD and Ibuprofen together?

Using CBD with medication is not just unsafe, but it also lowers the cannabinoid’s effectiveness. Some users might want to combine CBD with the medication to get instant relief. But is it safe? Does it even work?

Below, we answer all these questions while discussing the interaction of CBD with medicinal drugs.

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How Does Ibuprofen Help In Pain Relief?

Ibuprofen is one of the most commonly used painkillers in the world. It was discovered in 1961 and since then has become a widely-sold NSAID.

It’s available in a ton of household names, such as Brufen. As for effectiveness, the medication is quick to relieve most pains, even those resulting from inflammation. In some cases, it may also help reduce fever.

The medicine works by blocking a certain hormone called prostaglandin. The hormone is not secreted by a gland, unlike all other hormones in the body. Instead, it is only released at the site of need.

Typically, prostaglandins arrive at the site of tissue damage or infection.

Ibuprofen limits the working of the cyclooxygenase 2 enzymes. Owing to this, the prostaglandin release slows down, leading to lowering pain and inflammation. However, users must remember that Ibuprofen comes with its share of side effects.

Some of them include:

  • Heartburn
  • Dizziness
  • Strokes
  • Ulcers
  • High blood pressure
  • Heart attack

Most of these side effects manifest when the medication is used in a large amount.

How Does CBD Differ?

Humans have used cannabis for centuries against different ailments, but it was only recently that scientists realized that CBD is a non-intoxicating compound of the plant. The discovery was considered a revolution because it allowed us to use the plant without a high.

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The pain-relieving effects of Ibuprofen and CBD are similar in the sense that they both interact with certain receptors. However, while Ibuprofen stops enzyme production, CBD interacts with the CB1 and CB2 receptors.

At the moment, there’s not a lot of information about the precise working of CBD. Experts believe that it might affect the pain signaling pathways, preventing message transmission.

Can I Take CBD and Ibuprofen Together?

Currently, there’s not enough information about the interaction of CBD with medication. However, experts theorize that the compound hinders the working of medicinal drugs and might render them useless for the body.

Although there’s no detailed information on the subject, CBD drugs interactions fall into two categories:

  • The cannabinoid might act as an obstacle to the effectiveness of the drug.
  • The cannabinoid might bind with the drug, leading to chaos in the body.

In both cases, the results are not pleasant. On the one hand, you’re not getting any benefits from the medicine. On the other, you’re putting your body at the risk of unwanted effects.

The Journal of Neurology Research reports the absence of any interactions between Ibuprofen and CBD. However, that doesn’t mean you can take the two together.

At the moment, there isn’t enough research about CBD drug interactions to explain or figure out the cannabinoid’s effect on the body when used in conjunction with medicinal or recreational drugs.

CBD and other medications: Proceed with caution

Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.

Doubling up on side effects

While generally considered safe, CBD may cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare instances, damage to the liver. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly accidental falls and accidents when driving. Increased sedation and tiredness may also happen when using certain herbal supplements, such as kava, melatonin, and St. John’s wort. Taking CBD with stimulants (such as Adderall) may lead to decreased appetite, while taking it with the diabetes drug metformin or certain heartburn drugs (such as Prilosec) may increase the risk of diarrhea.

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CBD can alter the effects of other drugs

Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.

Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included

  • a common blood thinner, warfarin
  • a heart rhythm medication, amiodarone
  • a thyroid medication, levothyroxine
  • several medications for seizure, including clobazam, lamotrigine, and valproate.

The researchers further warned that while the list may be used as a starting point to identify potential drug interactions with marijuana or CBD oil, plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned), and may contain many other compounds that can increase the risk of unintended drug interactions.

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Does the form of CBD matter?

Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.

The bottom line: Talk to your doctor or pharmacist if using or considering CBD

CBD has the potential to interact with many other products, including over-the-counter medications, herbal products, and prescription medications. Some medications should never be taken with CBD; the use of other medications may need to be modified or reduced to prevent serious issues. The consequences of drug interactions also depend on many other factors, including the dose of CBD, the dose of another medication, and a person’s underlying health condition. Older adults are more susceptible to drug interactions because they often take multiple medications, and because of age-related physiological changes that affect how our bodies process medications.

People considering or taking CBD products should always mention their use to their doctor, particularly if they are taking other medications or have underlying medical conditions, such as liver disease, kidney disease, epilepsy, heart issues, a weakened immune system, or are on medications that can weaken the immune system (such as cancer medications). A pharmacist is a great resource to help you learn about a potential interaction with a supplement, an herbal product (many of which have their own drug interactions), or an over-the-counter or prescription medication. Don’t assume that just because something is natural, it is safe and trying it won’t hurt. It very well might.

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