Natural Alternatives to Prednisone for Dogs – February 2022
Prednisone is a corticosteroid used in alleviating symptoms of skin conditions, breathing disorders, arthritis, auto-immune and allergic reactions like hives (13 ) . It suppresses the immune system and inhibits the release of inflammation-causing substances in the body.
Patients’ immune response to Prednisone is positive. It treats auto-immune diseases like ulcerative colitis (inflammatory bowel disease), lupus, and psoriasis.
This corticosteroid also treats central nervous system disorders and hormonal disorders such as Addison’s disease, a rare disorder where the sufferer’s adrenal gland is unable to produce ample amounts of cortisol and aldosterone hormones (14 ) .
Prednisone vs. Prednisolone
Prednisone and prednisolone are both synthetic glucocorticoids (steroid hormones). They can treat the same auto-immune, skin, central nervous system, and hormonal conditions. However, Prednisone still needs to be converted by liver enzymes before it can take effect (15 ) .
Doctors are more likely to prescribe prednisolone to patients who have severe liver diseases or cats as they lack the enzyme needed to break prednisone to prednisolone.
Can Prednisone be Used on Dogs?
Prednisone may be used on dogs but must be administered with caution (16 ) .
It is often used to treat Addison’s disease by supplementing dogs with glucocorticoids that their own body is unable to produce.
Prednisone can also treat dogs for the following conditions (17 ) :
- Some cancer forms
- High blood calcium levels (hypercalcemia)
- Central nervous system disorders
- Skin disease
An article by Dr. Tammy Hunter, DVM and Dr. Ernest Ward, DVM reveals that even if Prednisone and Prednisolone are synthetic or human-made corticosteroids, they are more potent than those that are naturally found in the body. Their effects last longer, too (18 ) .
Dogs on Prednisone should be monitored carefully for side effects. According to Hunter and Ward, the benefits outweigh the risks when using Prednisone on pets (19 ) .
Few side effects will occur when the medication is used correctly.
Similar to many drugs in veterinary medicine, despite Prednisone’s benefits, its use in animals has not been approved by the U.S. Food and Drug Administration (FDA) (20 ) .
Prednisone Dosage for Dogs
If Prednisone is administered for its anti-inflammatory effects, the standard dosage for Prednisone in dogs is 0.5mg per kilogram. If it is used to treat immune system disorders in dogs, the dosage is 1mg per kilogram (21 ) .
When it comes to dosing Prednisone, use as much as is required to treat the symptoms but as little as possible to reduce the chances of the dog experiencing severe side effects (22 ) .
As soon as the dog’s condition improves, the slow tapering of the pet off Prednisone is suggested (23 ) .
According to Dr. Rania Gollakner, BS, DVM, in about 1 to 2 hours, Prednisone should take effect, and significant improvements in the dog should follow (24 ) .
Best combined with pet food, Prednisone comes in tablet, injectable, or liquid form (25 ) .
Dr. Barbara Forney recommends that Prednisone be given to dogs once daily, preferably in the morning (26 ) .
Side Effects of Prednisone on Dogs
Potential short-term side effects of Prednisone on dogs, especially on those who are taking it for its immunosuppressive properties are as follows (27 ) :
- Increased thirst
- Excessive urination
- Increased appetite
When Prednisone is given at higher doses or for long periods of time, more severe and long-term side effects may be observed (28 ) .
- Increased risk of infection
- Altered behavior including aggression
- Inhibited growth especially in young dogs
- Development or worsening of diabetes
- Cushing’s disease
- Ulceration of the digestive tract
- Delayed wound healing
A study conducted in 2015 revealed that dogs under corticosteroid treatment had shown adverse behavioral changes (29 ) .
It is also important to note that Dogs who are suffering from infections like fungal infections should not be given Prednisone. Corticosteroids will bring these out, even latent infections (30 ) .
Prednisone should also not be taken with drugs prone to causing ulcers, such as nonsteroidal anti-inflammatory drugs (NSAIDs), as doing so can result in stomach ulcers.
Natural Alternatives to Prednisone for Dogs
Because of Prednisone’s side effects on a dog’s body, some pet owners are turning to natural alternatives for their pet’s medical conditions.
Yucca Schidigera and Dogs
For joint pain and inflammation, Yucca Schidigera is a recommended natural alternative. Its extracts have anti-arthritic and anti-inflammatory effects (31 ) .
Yucca is a medicinal plant from Mexico. It is available in tablet form.
Turmeric and Dogs
Instead of treating dogs with anti-inflammatory drugs, turmeric is a good alternative. A 2009 study shows that turmeric, particularly its curcumin compound, can be used to treat inflammation (32 ) .
Aside from being anti-inflammatory, turmeric also has antibacterial, antitumor, and antioxidant properties (33 ) .
CBD Oil and Dogs
Another natural alternative to Prednisone for dogs is CBD (Cannabidiol) oil, a non-psychoactive cannabinoid.
Most CBD benefits are reported on humans, especially its positive effects on epilepsy, anxiety, and different types of chronic pain (34 ) . However, it is suggested that the system that regulates the functions of cannabinoids, the endocannabinoid system (ECS), is the same for all animal species except insects (35 ) .
If the ECS of a human and a dog work the same way, it is suggested that CBD oil can be given to dogs as well.
According to a 2017 article (36 ) , CBD shares metabolic pathways with anti-inflammatory drugs. Thus, it can help alleviate the inflammatory conditions Prednisone treats.
A 2018 study concluded that dogs suffering from osteoarthritis experienced a significant decrease in pain when they were administered with CBD oil. They were also perceived to be more comfortable and active (37 ) , with no adverse effects when they were observed short-term.
Prednisone treats shock in dogs because of its ability to improve circulation. Similarly, studies have shown that CBD reduces high blood pressure and heart rate in stressful situations (38 ) .
The 2017 study also revealed that CBD increases cerebral blood flow (39 ) .
CBD can also help treat a dog’s itchy skin. Its protective role of the ECS could help reduce allergy in the skin (40 ) .
A study also discusses CBD’s role as a potent inhibitor of cancer growth and spread. The research also suggests that CBD can be combined with classical chemotherapeutic agents (41 ) .
Once CBD is used alongside chemotherapeutic agents, their dose and toxicity are reduced while the efficacy is maintained.
While Prednisone alleviates asthma symptoms, CBD could also be as effective.
A study in 2015 states that CBD’s immunosuppressive and anti-inflammatory properties could help in the treatment of asthma (42 ) .
Despite these benefits, CBD also has side effects like dry mouth, lowered blood pressure, and drowsiness (43 ) .
The U.S. Food and Drug Administration has not approved CBD use, so a dosing chart for dogs is not available.
Dog owners should administer small amounts of CBD at first and then monitor its effects. CBD can be given orally, combined with pet food, or used in massages.
Before including CBD in the dog’s regimen, it is recommended that pet parents inform their veterinarian first.
CBD and Prednisone
CBD and Prednisone should not be taken together. The liver enzyme cytochrome P450 metabolizes Prednisone for it to take effect on the body.
A study shows that CBD inhibits the enzyme system, thereby raising risks like amplifying Prednisone’s side effects (44 ) .
Prednisone can be used on dogs. Short-term use already presents side effects, but the more concerning ones come from large doses and long-term use of the drug.
For inflammation in dogs, the dosage of Prednisone is 0.5mg per pound. For immune system disorders, the dosage is 1mg per pound.
Using Prednisone on pets for an extended period of time could bring about adverse effects; hence, natural alternatives like CBD oil are recommended.
CBD oil helps treat the symptoms Prednisone is used for sans the adverse effects. These symptoms include inflammatory conditions, arthritis, shock, skin conditions, cancer, and asthma.
Pet owners should consult with their veterinarian before giving CBD to their dogs.
Does CBD Oil Interact with Prednisone?
Prednisone is a medication which doctors often prescribe for inflammatory conditions. However, it has limited usefulness due to a range of potential side effects. This has led many patients to seek more natural alternatives, including CBD.
CBD has gained attention in recent years as a potent anti-inflammatory. Furthermore, scientists generally consider CBD to be safe, with a relatively low risk of side effects.
But is it safe to take prednisone and CBD together, or will the two interact and make matters even worse? Here’s all you need to know.
What Is Prednisone?
Prednisone belongs to a drug class known as glucocorticoids. These drugs are sometimes known as corticosteroids, or simply steroids. However, they should not be confused with the anabolic steroids that some athletes use.
How Does Prednisone Help Inflammation?
Prednisone works by mimicking the effects of glucocorticoid hormones that the body naturally produces. The adrenal glands secrete these hormones, and they play a role in various physiological functions. One of these functions is regulating the immune system and the inflammatory response.
Inflammation is a natural and healthy response to injury or infection. It allows the immune system to work more efficiently, enabling it to destroy invading pathogens. As a side effect, this process creates swelling, redness, and pain.
In the short term, this response is helpful as it reminds us to take extra care of ourselves while we heal. However, when inflammation fails to switch off when it should, serious problems can occur.
Chronic inflammation can cause pain, such as arthritis and joint pain. It is also associated with many serious conditions.
Glucocorticoid medications such as prednisone help to turn off inflammation by reducing activity in the immune system. Therefore, they can be used to treat a wide range of different medical conditions.
Some of the conditions for which doctors prescribe prednisone include:
- Skin disorders
- Autoimmune disorders (multiple sclerosis, lupus, etc.)
- Some types of arthritis
However, although prednisone is a useful medication with many indications, it can also cause some very unpleasant side effects.
Prednisone Side Effects
The side effects of prednisone include:
- Indigestion or heartburn
- Mood changes
- Increased risk of infection
When you take it over an extended period, prednisone can also cause more serious issues, including:
- Weight gain
- Glucose intolerance
- High blood pressure
- Increased risk of osteoporosis
- Stunted growth in children
Due to this long list of adverse effects, many people would prefer to replace their prednisone with natural alternatives like CBD. But is CBD effective for inflammation, and is this safe to do? Let’s take a look.
How Does CBD Help with Inflammation?
CBD has become popular in recent years as research highlights its many potential benefits. Probably one of the most well-publicized benefits of CBD oil is its anti-inflammatory effects.
CBD helps inflammation by interacting with the body’s endocannabinoid system (ECS). The ECS is made up of chemicals called endocannabinoids, enzymes, and cell receptors known as cannabinoid receptors.
The two main types of cannabinoid receptor are known as CB1 and CB2. CB1 receptors are mainly associated with the nervous system. CB2 receptors are found throughout the body, but they are concentrated in the immune system.
The ECS has many different functions. It helps to maintain a state of balance within the body, including controlling inflammation, immunity, and pain.
These functions are triggered when endocannabinoids bind to cannabinoid receptors. They fit together, like a lock fits a key to open a door.
Plant cannabinoids like THC have a similar chemical structure to these endocannabinoids. Therefore, they can fit into the same receptors and trigger the same reactions.
CBD is slightly different, though. It does not fit into these receptors directly but alters the way that they bind with other molecules, making them more or less effective.
When you take CBD oil, it influences the way endocannabinoids bind with CB2 receptors in the immune system. This helps to help turn off the inflammatory response.
In this sense, CBD is somewhat similar to prednisone. Both therapies can help to suppress the immune system by interacting with its cells.
However, unlike prednisone, CBD is not known to cause serious side effects. That is not to say that CBD will never cause any side effects at all, though. It’s just that they are unlikely to affect everyone or be especially severe.
Does CBD Interact with Prednisone?
If you suffer from an inflammatory condition and take prednisone, you might be wondering whether you can try CBD too. You might think that CBD is safe since it comes from a plant and causes very few side effects.
But unfortunately, despite its relative safety, CBD does have the potential to interact with other drugs. This means you should be cautious when adding CBD to your existing medication.
When you take CBD (or any medicine), it passes through your digestive system to your liver via the hepatic portal vein. In the liver, an enzymatic pathway called the cytochrome P450 pathway (CYP450) metabolizes CBD.
This process involves several enzymes, including one known as CYP3A4. This is an enzyme which is involved in metabolizing around 25% of all drugs, including CBD and prednisone.
Taking CBD can inhibit the action of CYP3A4. This means that other drugs metabolized by the same enzyme get broken down more slowly. Therefore, CBD can increase the concentration of drugs like prednisone in the body, raising the risk of side effects.
To find out whether your medication interacts with CBD, scientists recommend that you use the ‘grapefruit test.’ Grapefruit and grapefruit juice interact with many of the same drugs that CBD does.
So, if your doctor has told you to avoid grapefruit with your medicine, you should probably avoid CBD, too.
Is It Safe to Take CBD and Prednisone Together?
Since CBD oil can interact with prednisone, making side effects more likely, doctors don’t consider them safe to take together.
Sadly, this is the case for many other medications, too. Although for some people enhancing the effects of their medicine can be helpful, for others, it can be dangerous.
Therefore, if you suffer from an inflammatory condition and want to try CBD, you may need to stop your prednisone first. However, you must do this carefully and under the supervision of your physician.
Here’s what you need to know if you are thinking of making the switch from prednisone to CBD.
Making the Switch from Prednisone to CBD
If you use glucocorticoid medication like prednisone, it is essential that you do not stop taking it suddenly. Stopping this type of medicine without gradually tapering the dose down can result in severe withdrawal symptoms.
Some common prednisone withdrawal symptoms include:
- Extreme tiredness
- Joint pain
- Muscle stiffness
- Muscle tenderness
Therefore, if you want to stop taking your prednisone and try CBD instead, be very cautious. Talk to your physician first and explain why you want to make the change. Hopefully, they will be understanding and tell you how to stop taking your prednisone safely.
You may need to do this very slowly over the course of several days or weeks, so be patient. If your doctor is knowledgeable about CBD, they should be able to tell you when it is safe to start using it. In the meantime, ask about other ways to manage your symptoms, such as through diet or exercise.
Making the switch from prednisone to CBD is a slow process. However, it is essential to do it properly to avoid suffering even more.
Does CBD Oil Interact with Prednisone? Final Thoughts
CBD oil and prednisone are both useful anti-inflammatory treatments. However, the two substances are metabolized by the same enzyme, meaning that they can easily interact.
CBD can increase the likelihood of experiencing prednisone side effects, which is the exact opposite of what you want. Therefore, you should not take the two together unless your physician explicitly tells you to do so.
If you want to make the switch from prednisone to CBD, you should do so with caution. Suddenly stopping your medication can have unpleasant withdrawal effects, so talk to your doctor about doing this safely.
You may want to look into different ways to relieve your symptoms without medication while you make the transition. By finding ways to manage your condition with some simple lifestyle changes, you could make things much easier for yourself.
And finally, remember that CBD can interact with many drugs besides prednisone. Always consult your healthcare provider before taking CBD with any other medication.