cbd oil dose for ulcerative colitis

Medical Marijuana Oil Tinctures for Ulcerative Colitis

For several months now, I’ve been experimenting with medical marijuana oil tinctures for ulcerative colitis.

After a discussion with my medical marijuana doctor about his experience with UC patients and medical marijuana oil tinctures, I decided to give some products a try and report my results here.

I had several intentions in investigating medical marijuana oil tinctures for UC:

  1. Find a cost-effective alternative to smoking marijuana for UC
  2. Evaluate the efficacy of orally-delivered oil tinctures specifically in terms of my UC and bowel health
  3. Have a more easily transported and consumed mode of administration for my medical marijuana

In this post, Theraplant medical cannabis oil tinctures are used.

The medical marijuana oil tincture selection used for this post include a hybrid strain, a sativa strain and a 1:1 THC:CBD medical marijuana oil suspension.

Using Medical Marijuana Oil Tinctures for Ulcerative Colitis Offers the Benefit of Direct Digestive Tract Delivery

One of my main motivations for experimenting with cannabis tinctures was the direct delivery to the digestive tract with that mode of administration.

As my marijuana doctor explained this past September, administering the oil under the tongue gives the medicine a direct route to the bowel tissue.

His strong preference is using orally administered medical marijuana oil tinctures for ulcerative colitis and Crohn’s disease.

Is the Oral Delivery Route that Important?

I was skeptical at first about the oral delivery route. Could it really make much difference?

Spoiler alert: I think it actually does.

I’ve noticed some strong improvement in stool quality and gut comfort since incorporating some tinctures into my medical marijuana regimen for UC.

I’ve been doing really well for years now smoking, so saying I’m even better with some marijuana tinctures incorporated into my healing program for UC is really saying something.

My original assumption was that systemic THC and/or CBD was the main factor in using medical marijuana for UC. Now I believe delivery route can make a difference when using cannabis for UC. It’s definitely something worth experimenting with further.

The above is a 30mL bottle of Theraplant Pagoti hybrid medical marijuana oil tincture. This product has 27mg THC per mL.

Medical Marijuana Oil Tinctures as an Alternative Delivery Mode to Smoking for Ulcerative Colitis

For the past 6 years, my preferred administration mode has been smoking whole marijuana flower in a bong with ice.

Though still nothing like a California or Colorado dispensary, Connecticut medical marijuana patients have virtually every product category available.

Since I was already concerned about a chronic cough and congestion I was noticing, it seemed like a perfect time to give the tinctures a try and smoke a bit less.

Smoker’s Cough and Long-Term Medical Marijuana Use

A few years ago, I started to have a cough from time to time.

In the last few months, the cough was becoming chronic enough that I wanted to seek out alternative administration modes for my long-term cannabis usage.

I still like to smoke marijuana, but the idea of a smokeless, easily portable marijuana option was pretty attractive.

Anyone who uses marijuana long-term is going to find that smoking can’t be the only administration option available. It’s just too much on the lungs when using daily.

THC Oil Tinctures and CBD Oil Tinctures for Ulcerative Colitis

So far, I’ve used a hybrid medical marijuana strain as oil tincture and a sativa strain oil tincture.

I’ve also experimented with a 1:1 CBD and THC oil tincture.

The Theraplant medical marijuana oil tincture products I’m using currently for UC are:

Theraplant Pagoti (THC 81.5%)

Theraplant Savoti (THC 91.4%)

Theraplant CBD 1:1 (CBD 50.2%, THC 45.2%)

A Note About Strain Names and Connecticut’s Product Name Rules

The “Pagoti” above is a hybrid strain. The “Savoti” is a sativa strain.

Though it’s not impossible to find out what the actual strains are, it’s not that important in my opinion.

Most of the marijuana in the dispensaries here is a cross of 2-3 strains anyway. You can’t really look up the effects of a cross like that on Leafly anymore.

To make life easier, I rarely inquire about the actual strains anymore.

(I’m sure the dispensary personnel thank me too.)

I simply select products based on the broad categories of sativa, indica, hybrid and high-CBD.

50-State Legal CBD Oil Tinctures

Beyond my own recent successes with THC and high-CBD medical marijuana oil tinctures, I’ve seen good results in clients using 50-state legal pure CBD oil tinctures derived from hemp.

I’ve written extensively about the chemistry of CBD and THC in the post CBD and High-CBD Medical Marijuana – The Principal Guide

If you live in a state where medical marijuana isn’t legal yet, pure CBD oil tinctures derived from hemp can be a really good – and legal – option.

Dosing THC and CBD Medical Marijuana Oil Tinctures for Ulcerative Colitis

I’ve kept my dosage between 0.5mL and 1mL. Depending on the strain, this is in the neighborhood of 15-30mg of THC at a time.

With the high-CBD tincture, a full mL of solution will dose 15mg THC and 17mg CBD.

Medical Marijuana Oil Tinctures and Cost when Administering Over the Long Term for Ulcerative Colitis

Daily long-term cannabis use can get expensive.

Once the decision is made to give medical marijuana for UC a real try, cost per day and cost per dose will be something that needs to be looked into.

The following table was compiled from online dispensary menu data in December of 2021.

Above is a table of various medical marijuana products from my dispensary. There are the three medical marijuana oil tinctures that are the main topic of this post. There are also several Theraplant flower strains as well as a Theraplant 50mg capsule product and two medicated edible cookie products.

As I’ve said previously, marijuana flower is the most cost-effective way to use marijuana for ulcerative colitis. The price per mg of THC is always lowest with whole marijuana flower.

In this case, the cost per unit THC with marijuana flower is about $0.03/THC mg.

The second lowest cost per unit THC are the medical marijuana tinctures at about $0.08/THC mg for the sativa and hybrid.

The high-CBD medical marijuana oil tincture used for this post comes in with a cost per unit of CBD at $0.11/CBD mg and THC at $0.12/THC mg.

Price per unit of THC for the capsules are $0.12/THC mg and the edible products come in really high at $0.22/THC mg and $0.34/THC mg.

My Anecdotal Results Using Medical Marijuana Oil Tinctures for Ulcerative Colitis

The cough I was starting to have has pretty much vanished.

I’m smoking less and my overall THC consumption has reduced slightly also.

My stool quality has also improved dramatically from what was already an excellent state.

I’m convinced that there is something to the direct delivery route to the digestive/oral tissue when using medical marijuana oil tinctures for UC.

Less cannabinoid seems to do more for UC with the oral administration route, also.

Further, I like that the felt-effect of the THC comes on a lot slower, is less intense and lasts longer with the tinctures. It’s less of a “punch” of THC, relative to smoking a bong.

Conclusion

My recent experience with medical marijuana tinctures has been a very positive one.

My experimentation suggests that all of my initial requirements were met by the oil tinctures.

  • Lung and sinus health are better and the cough is significantly improved
  • Bowel health was positively affected by the tinctures
  • As shown in the table provided, marijuana oil tinctures are an affordable and cost-effective alternative to smoking

Based on my results and the data provided here, medical marijuana oil tinctures continue to be a part of my managing and healing regimen for ulcerative colitis.

Have you experimented with medical marijuana oil tinctures for UC or Crohn’s disease yourself? Have you used a 50-state legal CBD supplement for inflammatory bowel disease?

Accurate Education: Cannabidiol (CBD)- Clinical Use and Dosing

CBD has anti-inflammatory, anti-convulsant, anti-psychotic, anti-oxidant, neuroprotective and immunomodulatory effects but does not produce mind-altering effects like euphoria. CBD is a neuroprotective antioxidant more potent than Vitamin C (ascorbate) or Vitamin E (tocopherol). CBD is also thought to support sleep and reduce nausea, particularly related to chemotherapy. CBD, in combination with THC, modulates some of the side effects of THC, including reducing THC-induced anxiety and euphoria.

Links to other Pertinent Educational Pages:
Cannabidiol (CBD)

The medical information on this site is provided as a resource for information only, and is not to be used or relied upon for any diagnostic or treatment purposes and is not intended to create any patient-physician relationship. Readers are advised to seek professional guidance regarding the diagnosis and treatment of their medical concerns.

Key to Links:

Red text – another page on this website

Blue text – Journal publication

Cannabidiol (CBD) – Clinical Use

Contrary to popular belief, THC is not the most relevant cannabinoid for medical application, cannabidiol (CBD) is. CBD was first isolated in 1934 and first synthesized in 1967. While the clinical benefits obtained from marijuana (cannabis) are derived from the many constituents found in the plant, the two cannabinoids, THC (delta-9 tetrahydrocannabinol) and CBD (cannabidiol), together are responsible for the majority of the medical benefits. CBD has the advantage over THC in that it is associated with fewer side effects; notably it lacks the euphoric effect or high that impairs thought processing. Furthermore, CBD is now legally available over-the-counter in Louisiana and offers a new and accessible alternative means of treating a number of symptoms and conditions including chronic pain.

For more information regarding CBD products, See: Cannabidiol (CBD) – Introduction

In a quick overview, current research on CBD suggests it has the potential to be an effective anti-anxiety and antipsychotic drug. It is also considered to be a possibly useful drug for cancer, diabetes, inflammatory and neurodegenerative disorders. CBD is known to have anticonvulsant effects and to be neuroprotective. It is a strong antioxidant and may offer benefit for oxidative stress, the underlying process behind many diseases of aging. CBD has anti-nausea and analgesic effects, possibly reducing the exaggerated and physiologically inappropriate responses to pain frequently found in conditions such as migraine headaches and fibromyalgia. Furthermore, CBD shows toxicity to breast tumor cells and helps preserve normal cells. Also, CBD shows potent antibacterial effects against methicillin-resistant Staphylococcus aureus (MRSA), the bacteria responsible for many serious infections currently resistant to commonly used antibiotics. Finally, CBD may reduce stroke risk and offer protection against heart attacks.

While the above general benefits are commonly attributed to CBD, quality research is still lacking as to identifying specific benefits associated with specific medical conditions, definitive dosing and which cannabis-based constituent combinations are the most effective.

Conditions Potentially Responsive to CBD

Because CBD has become commonly available in pure, THC-free formulations, it is important to evaluate what therapeutic benefits may be obtained with its use. The FDA did, however, recently approve one pharmaceutical prescription form of cannabis plant-derived CBD, an oral solution called Epidiolex. It is FDA-approved for the treatment of certain rare pediatric epilepsy conditions (see: Epidiolex, below). Aside from these pediatric epiplepsy conditions, specific definitive therapeutic benefits of CBD still lack good quality scientific evidence.

Possible Therapeutic Benefits

There are many conditions for which CBD has been suggested to be effective, consistent with CBD’s neuroprotective, antiepileptic, hypoxia-ischemia, anxiolytic, antipsychotic, analgesic, anti-inflammatory, anti-asthmatic, and antitumor properties. Some of these conditions include inflammatory and neurodegenerative diseases (Alzheimer’s, Parkinsons Disease and Chronic Traumatic Encephalopathy (CTE) associated with brain trauma), epilepsy, autoimmune disorders like multiple sclerosis, arthritis, schizophrenia and cancer. The reduction of intestinal inflammation through the control of the neuroimmune axis suggests CBD may be a promising drug for the therapy of inflammatory bowel disease, especially Crohn’s disease and Ulcerative Colitis.

The following is a list of conditions that may respond to CBD:

  1. Pain
  2. Anxiety
  3. Addiction
  4. Inflammatory Bowel Disease (Crohn’s & Ulcerative Colitis)
  5. Muscle Spasticity (in Multiple Sclerosis)
  6. Neurodegenerative Disorders (Alzheimers & Parkinsons Diseases
  7. Seizures
  8. Traumatic Brain Injury & Chronic Traumatic Encephalopathy

While use of cannabis and various cannabis-based products have been shown to provide pain relief and reduce pain unpleasantness, the effect of CBD alone on acute or chronic pain is still not well understood. A few animal studies suggest that CBD can be used to control inflammatory and neuropathic pain. In rat models, it has been shown that CBD exerts anti-hyperalgesic effects on neuropathic and inflammatory pain. However, some studies show that cannabinoid benefits for pain are only marginally superior to placebo in terms of effectiveness but actually inferior to placebo in terms of tolerability/side effects.

A 2018 narrative review summarized the literature regarding the use of cannabinoids for the treatment of neuropathic pain. Like THC, cannabidiol has been shown to reduce the pain associated with various neuropathic pain models in preclinical animal studies. However, it has been suggested that CBD has a maximal analgesic effect (efficacy) that is only half of that observed for THC. Unlike THC however, CBD does not produce cannabis-like side effects even at high doses, which suggests that cannabidiol has a very wide therapeutic window, compared to THC which has a therapeutic index of only 5-6 – meaning that it produces analgesia with a dose only 5–6 times lower than that at which it produces side-effects.

It has been noted that some studies show that the analgesic efficacy of CBD improves with chronic treatment.. Thus, while CBD offers a potential alternative therapy for pain, to date (2018), there are no major human clinical studies on the effectiveness of CBD for the treatment of (neuropathic) pain.

Preclinical Study Evaluating Synergy Between Morphine and a CBD-2 Agonist

A 2017 preclinical study showed for the first time that morphine and a CB2 agonist, JWH015 (like CBD) interact synergistically to suppress inflammatory, post-operative, and neuropathic pain. Furthermoe, the synergy extends to preventing opioid-induced reward behaviors in animals, suggesting that CBD may reduce abuse risk when taken with opioids. Additionally, the combination of morphine with the CB2 agonist reduces constipation associated with morphine. The authors conclude that their data support the use of opioid-CB2 combination therapy in treating chronic pain while limiting abuse liability.

Topical CBD for Pain

CBD may be used effectively as a topical salve for pain, including arthritis pain and muscle pain related to spasm. An interesting 2019 study evaluated a commercial brand of CBD oil (Charlotte’s Web Hemp Extract Oil) blended with cholesterol ointment (20% CBD oil) applied topically to the masseter muscles in patients with TMJ pain. When the compound was applied twice a day for two weeks, patients experienced less pain and measurements indicated less spasm of the masseter muscles.

Anxiety
Addiction
Inflammatory Bowel Disease (IBD) – Crohn’s & Ulcerative Colitis

The inflammatory bowel diseases (IBD) include chronic immune-mediated inflammatory diseases of the intestinal tract, typified by Crohn’s disease (CD) and ulcerative colitis (UC). Their development is complex and involves genetic and environmental factors, among which diet and the intestinal microbiota are common targets for prevention and treatment. Some of the most common symptoms of IBD are abdominal pain, diarrhea, and weight loss. However, one of the major challenges in management of IBD is to reduce and/or reverse the underlying intestinal inflammation characteristic of these diseases.

Enteric Glial Cells (EGC)

Both the acute and chronic inflammation in the gut associated with IBD is related to immune cells called g lial cells. The enteric glial cells (EGC) located in the gut are functionally similar to those found in the central and peripheral nervous system. They function to maintain balance in nerve and neurotransmitter activity, providing support and protection for enteric nerve cells. EGC play a fundamental role in the maintenance of gut homeostasis where they are the first defensive line against infection by supplying nutrients and oxygen to aid in the repair of damaged cells.

As with the process of neuroinflammation related to chronic nerve pain (See: Neuropathic Pain ) and neurodegenerative brain diseases, EGC may also proliferate and become perpetually activated leading to the chronic inflammation associated with IBD. This is characterized by the ongoing release of multiple pro-inflammatory chemicals as well as stimulating the infiltration of other immune cells such as macrophages, neutrophils and mast cells.

Despite extensive pre-clinical evidence, only two studies have assessed the effectiveness of CBD. The only study assessing the efficacy of CBD in Crohn’s Disease (CD) was negative, with no improvement in disease activity as measured by a CD Activity Index (CDAI), as well as several laboratory parameters. Of note, however, the treatment was safe, and the negative results nay have been due to the small number of cases and the very low dose tested (10 mg, orally) as well as the lack of synergism with other cannabinoids. Another study addressed the effects of a CBD-rich botanical extract in Ulcerative Colitis (UC). This study found a lack of benefit and a lack of tolerability of the botanical extract. However, there was a trend toward improved quality of life scores suggesting that the CBD-rich botanical extract may have provided therapeutic benefit to those patients who tolerated it.

A recent meta-analysis that reviewed the evidence of cannabis and CBD on UC and CD was unable to make any definitive conclusions on their safety or effectiveness in IBD. It was concluded that further studies with a larger number of patients, different doses and routes of administration are still necessary and the use of CBD and other phytocannabinoids should be considered for clinical studies.

Neurodegenerative Disorders

Alzheimer Dementia (AD)

Alzheimer’s dementia (AD) is a type of dementia in which deposits of “senile” plaques form in the brain. These plaques consist of a neurotoxic substance called beta-amyloid peptide (Aβ) and they contribute to inflammation and oxidative stress, both crucial components of AD. Microglia are immune cells found in the nervous system that when activated under certain condions produce pro-inflammatory chemicals (cytokines ) that increase Aβ production by nerve cells.

The role of Aβ in inflicting nerve damage and neuroinflammation in AD is well established. Numerous studies exploring CBD in neurotoxicity have shown CBD to exhibit beneficial effects against the neuroinflammation and damaging action induced by Aβ due to CBD’s combination of antioxidant and anti-inflammatory properties, mechanisms not shared by classic antioxidant drugs. CBD exhibits beneficial effects in animal models of neuroinflammation by reducing mictoglia activation and their production of pro-inflammatory compounds.

Parkinson’s disease (PD) is a motor neurodegenerative disorder, in which the main feature is a progressive death of dopaminergic neurons, resulting in slowing of movement (bradykinesia), rigidity and tremor. There is substantial growing evidence for a role for CBD as a potential pharmacological approach to PD. Animal studies have been encouraging but only a few small trials have been conducted on Parkinson’s disease patients.

Traumatic Brain Injury (TBI) & Chronic Traumatic Encephalopathy (CTE)

Traumatic brain injury (TBI) is a growing health concern that affects millions of individuals. TBI can lead to a debilitating condition called Chronic Traumatic Encephalopathy (CTE), a neurodegenerative disease thought to be associated with a history of repetitive head impacts, such as those sustained through contact sports or military combat. CTE develops symptoms slowly, often developing over years, and is often unrecognized and undiagnosed.

Like AD, CTE is associated with abnormal development of beta-amyloid peptide (Aβ) and also a protein called “tau” which are believed to underly the functional brain impairment associated with the condition. Encouraging research regarding CBD and another agent, palmitoylethanolamide (PEA), indicates they work synergistally in protecting against the development of CTE.

So far, no treatment has been shown to cure AD, PD or CTE and no treatment has been FDA-approved to slow or reverse the neurodegenerative processes of these diseases. While it is much too early to make therapeutic claims for CBD in these conditions, given the benefits of CBD as an anti-inflammatory, neuroprotective, immune-modulating agent and considering its safety record, CBD represents an attractive potential therapeutic alternative for these patients.

Dosing of CBD

Specific dosing of CBD needs to be guided individually, taking into account desired therapeutic benefits related to specific symptoms and disease processes as well as the potential for drug-drug interactions with other prescribed medications. Dosing should be guided by a physician knowledgeable about cannabis and cannabis-based products. CBD suppresses the “high” caused by THC when provided at an 8:1 CBD:THC ratio.

Incidentally, due to lack of government regulation and oversight, CBD products sold online are often mislabeled regarding constituents, qualitatively and quantitatively. Caution is necessary when purchasing CBD products, including confirmation of product quality by obtaining 3rd party chemical analyses that evaluate product contents. Without this information, predicting accurate dosing from a product becomes very unreliable. Legitimate manufacturers provide these chemical analyses on demand and will often have them available on their websites.

CBD can be effective at a very wide range of dosages. It has been found that very low doses can have a very profound impact, from as little as 2.5 mg of CBD daily depending on method of delivery. Doses up to hundreds of milligrams have also been used safely and effectively. In a study that evaluated daily oral doses of 700mg, CBD was found to be nontoxic and other studies have reported CBD doses up to 1500mg/day to be safe. It has also been reported that cannabinoids may have a biphasic or triphasic effect, in that a low dose may provide a certain effect, but higher doses may provide different or opposite effects.

A very high dose may also not provide additional benefit over a low dose, so it’s best to start with a low dose: 2.5-5 mg of CBD initially (maybe 10 mg at the most), depending on the product and method of use. A typical starting CBD dose for most people would be a total of 10-12 mg of CBD a day, divided into 3 daily doses. If the desired effect is not achieved at a low dose, then higher doses can gradually be introduced until the therapeutic goal is achieved or side effects or expense deter further increased dosing.

The use of tinctures sublingually will be expected to provide a more rapid onset of effect but may not last as long as an oral dose. Orally administered (swallowed) CBD oil can last for four hours or more, but the onset of effects is much slower (30-90 minutes) than a tincture administered sublingually (under the tongue). Tincture dosing is generally performed with a 1 ml dropper which provides about 20 drops/ml.

Did you know that CBD can be used to treat a whole array of troublesome medical conditions? And that includes Ulcerative Colitis and Psoriasis

And that’s not all, CBD products have also been used by thousands of patients, to treat things like Graves disease, Crohn’s, and even mental issues like anxiety and depression. In our last Q & A session, many interesting questions were put forward, which deserved some great answers…

Question: I have ulcerative colitis, anxiety, and psoriasis. I just heard of CBD oil and the people at CBD testers appear very knowledgeable and trustworthy, so I’m going to approach your company first. Please help me.

CBD is an effective anti-inflammatory agent. CBD binds to the enteric glial cells that line the intestine and protect the lining from the inflammation caused by intestinal pathogens.
Taking CBD orally is the best delivery because the CBD can work directly at the location of the active colitis.

Dosage recommendation: Start with 1-2 drops sublingually every 15-20 minutes. Continue until you have pain relief. When you are stabilized, increase the interval to every 2-3 hours when needed. When you are symptom-free, then switch to an oral dose and take it twice a day for at least six weeks.

Delivery system to treat psoriasis:

In psoriasis, the skin cells are replaced every 3 to 5 days rather than the normal 30 days. The excessive and rapid growth of the epidermal layer of the skin results in itchy & scaly patches.

The most effective and efficient delivery system is CBD balm. The balm penetrates the epidermal lining and its effects extend down to the subcutaneous tissue. The CBD balm goes directly to the affected areas to reduce the itchy scaly plaques.

CBDistillery – CBDol Topical Salve (500mg)

Looking for CBD Balm? Click HERE

Question: I took amitriptyline for twenty years. The doctor switched me to mirtazapine – without tapering me off it. The reason I have been on medication is that I have insomnia. I would like to know if I can take CBD while taking mirtazapine.

Mirtazapine is metabolized in the liver mainly by the CYP2D6 and CYP3A4 isoenzymes.
Mirtazapine does not inhibit other CYP isoenzymes and, therefore, when other medications or botanicals are given with mirtazapine, the other medications or botanicals (such as CBD) are not affected. CBD is metabolized in the liver. It inhibits the metabolism of some medications broken down by Cytochrome P450 3A4 & Cytochrome P450 2C19. It is not metabolized, nor does it affect the metabolism of mirtazapine. Therefore, mirtazapine and CBD can be taken together. By the way, CBD is excellent for sleep.

Dosage recommendation: The dose used is usually 40-mg but can be as high as 160-mg. Start low, and go slow. It is possible, that the CBD may be able to replace the mirtazapine, however, this should be discussed with your health care provider.

Question: Does CBD show up on a urine employment random drug test?

Workplace drug screens check for THC. They do not check for CBD. If the urine screen comes back positive for THC, then the cannabinoid you were using THC (even if you THOUGHT you were using CBD only. This is just one of the many reasons why you need to be very diligent when you purchase CBD. At CBD Testers, the supplies you purchase are reliable. The dose, purity, and safety are assured.

Question: I have psoriasis. My doctor has me on methotrexate. Is it safe to use CBD while on methotrexate?

Methotrexate (MTX) is an anti-neoplastic anti-metabolite with immunosuppressant properties. Methotrexate selectively affects the most rapidly dividing cells (neoplastic and psoriatic cells). Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication.
Renal excretion is the primary route of MTX elimination. Less than 10% of MTX undergoes hepatic elimination. When taking MTX, sometimes, the MTX dose can be lowered because MTX is a substrate of CYP450 3A4, where CBD is an inhibitor. You may wish to discuss this with your doctor. I researched THC as well for you. THC is NOT safe to take with MTX. Bottom line: Yes, you can take CBD with MTX.
Ref:
1. “In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase.” Drug Metab Dispos. 2010 Aug;38(8):1322-1327
2. “Herbal cannabis (THC) not recommended for rheumatology patients.” ScienceDaily. ScienceDaily, 3 March 2014.

Question: I have psoriasis – inverse, plaque and guttate. Recently I’ve started to show the beginning symptoms of what is most likely psoriatic arthritis. The psoriatic arthritis I now have has also become complicated by depression and fatigue. Do you think that CBD may help me? If so, what dose?

Biotech CBD Cream 1000MG (Diamond)

In psoriasis, the skin cells are replaced every 3 to 5 days rather than the normal 30 days.
The excessive and rapid growth of the epidermal layer of the skin results in itchy & scaly patches. The condition may be localized or completely cover the body. In 30% of people the disease starts to involve the cartilaginous areas followed by the bone and finally the visceral organs. Psoriasis is not contagious and there is no cure for it, however, various treatments can control the symptoms. Do NOT SMOKE. Do not smoke cigarettes. Do not smoke “weed”. Do not smoke period.

The smoke created via combustion releases carcinogens and other skin-damaging radicals into the air – and will aggravate your psoriasis. CBD controls psoriasis by balancing the immune system’s response. You can use CBD lotion, CBD tinctures, or CBD soft-gels.

All will work because there are cannabinoid receptors both in the skin cells as well as in the internal organs. I would suggest starting with CBD oil and not CBD cream because your psoriasis is diffuse and has already progressed to involve your internal organs.
Begin with 5-mg twice a day and slowly taper it up.
You will initially feel a “lightening” of your depression. It will feel as if a cloud has lifted.
As you taper up you’ll then notice a “tingly” sensation on your skin, and the patches will begin to fade. Following that, the achiness will lessen.

Looking for CBD Balm? Click HERE

Ref:
1. “Cannabidiol exerts sebostatic and anti-inflammatory effects on human sebocytes” J Clin Invest. 2014 Sep 2; 124(9): 3713–3724.
2. Cannabinoid system in the skin – a possible target for future therapies in dermatology. Exp Dermatol. 2009;18(8):669–679.