cbd oil especially for ms

CBD for Multiple Sclerosis: Efficacy & Best Products (CBD Gummies, CBD Oil)

As legalization of cannabis in the United States continues to evolve, more Americans are turning to CBD (cannabidiol) for its potential health advantages — without the high that comes with tetrahydrocannabinol.

Many people suffering from chronic diseases, such as multiple Sclerosis (MS) can use CBD to reduce their symptoms. Although the results of research are still incomplete, CBD has shown some promise in helping to alleviate chronic pain and discomfort associated with various conditions.

We’ll be discussing how CBD can help with MS symptoms. We will also discuss how to buy CBD and how to use it.

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Basics

CBD is an extract of the cannabis plants that’s markedly distinct from THC. It doesn’t give you that high that’s often associated with cannabis.

There are many cannabinoids found in cannabis, but CBD or THC are the ones you most often hear of.

Although research is still in its infancy, there are promising signs that CBD may be able to relieve pain and anxiety.

There are three types.

CBD isolate contains pure CBD. It does not contain THC or other cannabinoids. It’s possible that it may contain solvents because of its high-refined nature.

It is important to search for products with a certificate or analysis (COA). Third-party testing verifies that no ingredients were left behind in the purification process.

The full-spectrum is the other form of CBD. Broad-spectrum CBD doesn’t contain THC, but it does contain other cannabinoids. Full-spectrum CBD contains very little THC, but can be more effective than other forms due to the “entourage” effect.

The U.S. Food & Drug Administration (FDA), has approved only one CBD drug currently on the market: Epidiolex. This is for rare forms of epilepsy.

How CBD could help with multiple sclerosis symptoms

As an alternative to using habit-forming drugs such as opioids, some people turn to CBD for chronic pain management. There is not enough evidence to support CBD’s pain relief benefits. However, what we do know is encouraging.

These symptoms are common in MS and CBD could help:

  • fatigue
  • Mobility
  • spasticity
  • Nerve-related Pain or Discomfort
  • Itching and pain

An 2018 review found that CBD is a very effective tool for pain management with few side effects. These studies examined pain that was a result of:

  • Cancer
  • neuropathy
  • fibromyalgia

Inflammation

Researchers also studied CBD’s anti-inflammatory properties. A 2015 animal study showed that arthritis rats who received 6.2 mg CBD per day experienced less swelling and pain than rats who did not receive any CBD.

These results are fascinating, but further studies on humans are needed to confirm them.

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MS symptoms

Some studies also examined whether CBD could help MS patients manage their symptoms. The majority of research focuses on the effects of CBD and THC together in an oromucosal spray called Sativex.

A 2014 summary suggests that Sativex may be an effective treatment option to treat MS-related symptoms like spasticity, infrequency and pain.

A 2018 study which examined the effects of Sativex on driving abilities of people with MS discovered that there was no increase in car accidents for those who took the spray. A few people also claimed to have improved their driving skills, possibly due to less spasticity.

Another study by 2018 showed that cannabis products with a 1 to 1 CBD-to-THC ratio could reduce muscle spasticity in MS patients. This may lead to improved mobility for those with MS.

The National MS Society supports legalization at the state level of cannabis and seeks to remove federal obstacles to research into medical cannabis. They also point out that no research has been done on cannabis safety, particularly in MS patients.

How to Take CBD

CBD can be found in many forms including:

  • Tinctures and oils can be taken orally by placing drops underneath the tongue. These options are great for people who have difficulty swallowing pills.
  • Lotions and creams. Topical cannabis products are great for joint and muscle pain . You can use them to treat certain skin conditions. They are not suitable for treating whole-body problems like insomnia.
  • Capsules or Gummies. People with whole-body problems may prefer to take pills. Some people are uncomfortable with pills and capsules. It can take a while for CBD to start producing results in this form. Gummies are a great alternative to taking pills or capsules.
  • Experts do not recommend this method of CBD use because of possible adverse effects to your health.

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How do you find high quality CBD products

These are some questions you should ask when looking for CBD.

What type of CBD do you use?

A full-spectrum product will give you the maximum entourage effect benefits. You can choose CBD isolate or broad spectrum CBD if you prefer to stay away from THC.

Remember that CBD products could contain trace amounts THC. This could be detected on a drug test.

Is the company able to test its products in a third party lab?

The FDA does not test or guarantee safety for CBD products that are over-the-counter. The FDA can issue warning letters to companies that make health claims they shouldn’t but that’s it.

A COA should be included with any quality product. It should confirm that it is free from contaminants and that it contains the CBD (and/or THC) that’s indicated on the label.

What is in this CBD product?

Look out for products that claim to contain hemp, hemp extract, and hemp oil. Products that claim they contain hemp oil or hemp seeds do not contain CBD.

It is also a good idea for you to verify where your ingredients are sourced. Look for hemp-based products made in the United States.

Are you still unsure which CBD product to buy? We have compiled a list of recommendations.

How did we choose the best CBD products to help people with MS

These products were chosen based on criteria that we consider to be good indicators of safety, transparency, and quality.

This article contains information about each product:

  • A company that can provide proof of third-party testing done by an ISO 17025 compliant lab
  • Made with U.S.-grown hemp
  • According to the COA, it contains less than 0.3 percent of THC.
  • According to the COA, passes all tests for pesticides and heavy metals as well as molds.

We also considered the following factors as part of our selection process:

  • The company’s manufacturing processes and certifications
  • Product potency
  • Overall ingredients
  • These are indicators of brand trust and brand reputation.
    • Customer reviews
    • If the FDA warning has been sent to the company
    • If the company makes unsupported claims about health

    Pricing guide

    • $ = under $30
    • $$ = $30-$50
    • $$ = more than $50

    Health’s top picks for CBD products that are best for people with MS

    Lazarus Naturals High Potency CBD Tincture

    • Price: $-$$$
    • Full-spectrum: CBD type
    • CBD potency: 750 mg per 15-mL bottle, 3,000 mg per 60-mL bottle, or 6,000 mg per 120-mL bottle
    • COA Available on the product page

    This high-potency full spectrum CBD product is a favorite in the Lazarus Naturals line. Many reviewers say they enjoy using it at night. Easy dose control is possible with a dropper.

    Unflavored tinctures have an earthy flavor that may not be for everyone. There’s a plus! It is free from additives. It is also vegan- and gluten-free.

    For 10% off your first order, use code “Health10”. Only one time use

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    Joy Organics Premium CBD Gummies

    • Price: $$
    • CBD type broad spectrum
    • CBD Potency: 10mg per Serving
    • Count: 30
    • COA: available online

    These delicious, broad-spectrum CBD gummies are available in two flavors: strawberry limeade or green apple.

    undefined Gummies can also be made vegan with organic sugar.

    Get 15% off with code “healthcbd”.

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    Medterra CBD Capsules

    • Price: $$
    • CBD type isolate
    • CBD potency: 25 mg or 50 mg per capsule
    • Count: 30
    • COA: available online

    These capsules contain CBD from non-GMO, organic hemp. These capsules also contain CBD isolate which is great if you want to avoid THC.

    The U.S. has certified the company. Hemp Authority offers a 30-day money back guarantee. This makes it an excellent choice for CBD novices.

    Get 15% off by using the code “health15”.

    Side effects and safety of CBD

    While CBD is generally considered safe there are still potential side effects. Some people might experience adverse reactions.

    • diarrhea
    • Fatigue
    • Weight changes
    • Changes in appetite

    Before you try CBD, make sure to talk with your doctor. This is especially important if you are currently taking any medication. CBD can interact with certain drugs.

    Takeaway

    To better understand the role of CBD in MS symptoms management, more research is needed.

    Research suggests that CBD alone may be able to treat chronic pain and insomnia, as well as nerve pain. These symptoms may be experienced by people living with MS. CBD could help to manage them.

    Frequently Asked Questions

    UM’s research interests include studies of the botanical, pharmacological and chemical properties of the cannabis plant. In addition to supporting the research community through UM’s participation in the National Institute on Drug Abuse (NIDA) Drug Supply Program, UM collaborates with industry partners in support of the development and commercialization of FDA-approved drug products derived from cannabis. UM’s expertise in drug delivery is used to develop optimized formulations for evaluation in animal models and human clinical trials.

    What is Harper Grace’s law?

    Answer:

    Mississippi Code § 41-29-136 (2017), known as Harper Grace’s Law, was enacted by Mississippi legislators in response to the needs of young patients who suffered from certain epileptic conditions. This law allows physicians to conduct clinical research studies at the University of Mississippi Medical Center (UMMC) using a cannabis extract oral solution enriched in cannabidiol (CBD) and very low tetrahydrocannabinol (THC) content. The concentrated extract is prepared and provided by the National Center for Natural Products Research (NCNPR) at the University of Mississippi, and the oral solution is dispensed by the UMMC Pharmacy for the purpose of these investigational trials. The intention is to evaluate the safety of this treatment in patients eligible for the studies under the guidance of physicians at UMMC. For the study, patients and their families are allowed to use the experimental drug without prosecution for controlled substance violations. The law also allows preparation of the CBD solution by other pharmacies or laboratories under the appropriate federal and state regulations.

    Harper Grace’s Law expires on July 1, 2024.

    What is the difference in marijuana and hemp?

    Answer:

    The scientific name Cannabis sativa L. describes a single species of the cannabis plant that has multiple varieties that may be identified by their physical and chemical characteristics. The terms “marijuana” and “hemp” describe varieties having high and low levels of tetrahydrocannabinol (THC) respectively. While both have medicinal value, marijuana has traditionally been abused for its psychoactive effects, while hemp has traditionally been used for industrial purposes such as seeds and fiber products. Both have been considered DEA Schedule-I controlled substances for decades in the U.S., but the 2018 Farm Bill includes amendments to the Controlled Substance Act (21 U.S.C. 812) which makes the hemp variety (with <0.3% THC content) no longer a controlled substance. Marijuana, however, remains as Schedule-I.

    How has the federal legalization of hemp affected the cannabis work at UM?

    Answer:

    Hemp legislation under the Farm Bills of 2014 and 2018 were intended to promote research and commercialization of hemp-based products which had previously been curtailed due to hemp’s designation as a DEA Schedule-I controlled substance. The 2018 Farm Bill clarified the definition of hemp based upon the measured level of tetrahydrocannabinol (THC) in the plant and in products derived from the plant. Although hemp is no longer a DEA controlled substance, its cultivation is regulated by USDA. Because NCNPR has a long history of advancing safe and effective utilization of botanicals for health and medicinal applications, we will embrace the prospects afforded by any federal legalization of the cannabis plant.

    Does cannabis have medical benefits?

    Answer:

    Dronabinol, the active ingredient in FDA approved Marinol® capsules and generic equivalents, is synthetic delta-9-tetrahydrocannabinol (THC). THC is a naturally occurring compound in cannabis. Dronabinol is approved as a prescription drug product in many countries for the treatment of anorexia associated with weight loss in patients with AIDS, as well as for nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments. Sativex®, a standardized cannabis extract containing THC and cannabidiol (CBD), is approved as a pharmaceutical product for the treatment of MS Spasticity in over 25 countries, but not the U.S. The oral solution of purified CBD in sesame seed oil, Epidiolex®, has been approved in the U.S. and other countries for the treatment of certain seizure disorders.

    Additional clinical research is needed to better understand the safety and efficacy of cannabis, especially in the smoked form. For a complete listing of all projects funded by the National Institutes of Health (NIH) examining the potential therapeutic benefits of cannabinoids, see the Therapeutic Cannabinoid Research category in the NIH RePORT database.

    Is the University of Mississippi the only legal marijuana grower in the U.S.?

    Answer:

    Under the 1961 international Single Convention on Narcotic Drugs and the 1970 Controlled Substances Act, the federal government is the single “agent” allowed to provide marijuana for research. For many years the DEA only authorized one grower, the University of Mississippi, which grows marijuana under contract with the National Institute on Drug Abuse. As part of this contract, UM holds a DEA Schedule-I Bulk Manufacturer registration to cultivate plants for this purpose. However, in 2016 DEA announced a new interpretation of the Single Convention to allow other growers to cultivate marijuana, but with DEA as the single agent rather than NIDA. Other growers are now approved to cultivate marijuana for research and for product development.

    How does a grower apply for a DEA registration?

    Answer:

    To be registered as a “marijuana grower” under a DEA Bulk Manufacturer registration:

    1. An applicant must submit an online registration request to DEA, using the DEA Form 225 link.
    2. DEA will review the application and ask the applicant to provide additional information, such as the type of materials to be manufactured (bulk marijuana, marijuana extract, or purified cannabinoids).
    3. DEA will publish in the Federal Register the application information for comments.
    4. During or after the comment period the DEA will arrange for a site visit to inspect the applicant’s provisions for security and storage.
    5. If the applicant meets all requirements for a registration (2, 3 & 4) the DEA sends the applicant a draft Memorandum of Agreement (MOA) for the applicant to sign to serve as a legal agreement between the registrant and DEA for production of marijuana.
    6. Once a MOA is in place, the DEA will issue the registration.

    How much marijuana does the facility grow?

    Answer:

    UM grows various amounts of different varieties of cannabis to meet the anticipated needs of researchers under the National Institute on Drug Abuse contract. A typical outdoor growing season yields over 500kg of plant material, while an indoor season yields about 10kg.

    Why does marijuana grown at the facility look different from marijuana in dispensaries?

    Answer:

    Marijuana produced at UM is manicured to a uniform particle size because it is required to be standardized in various research protocols.

    How can researchers request other forms of marijuana?

    Answer:

    Researchers should send requests to the project officers of the National Institute on Drug Abuse Drug Supply Program: Robert Walsh, (301) 443-9825, or Rik Kline, (301) 827-5243.

    What is CBD oil?

    Answer:

    For the purpose of the University of Mississippi’s R&D program, “CBD oil” is referred to as “CBD extract oral solution.” It is prepared from the plant extract, which is formulated for pharmaceutical use, and is suitable for oral administration. The current product version contains 50 mg/ml CBD, or cannabidiol, and not more than 2.5 mg/ml of THC.

    UM’s CBD oil product is prepared from a concentrated extract of Cannabis [CBD-enriched Cannabis extract] with a high ratio of CBD to THC, or tetrahydrocannabinol.

    Note that the term “CBD oil” is used fairly indiscriminately by marketers and users, and may refer either to concentrated oily residues of the plant, or to many derived products with different oils added. These products may vary highly in CBD content, quality, purity and in the content of other cannabinoids.

    Is your marijuana free of microbial and heavy metal contamination?

    Answer:

    UM performs quality control testing to ensure that the products meet quality standards for botanical products. Certain bacteria, such as E. coli and Salmonella, cannot be tolerated in products intended for human ingestion. The natural flora of yeasts and molds that occur on plants of every species also occur on marijuana plants. The level of yeast and mold expected in normal flora are of little concern, but higher levels, such as visible mold, are not allowed. As cannabis plants grow, any heavy metals in the surrounding soil will be concentrated in the tissues of the plants. Although the risk of metal contamination in plants grown under controlled conditions is very low, UM tests representative samples for heavy metal contamination.

    Since many states now have laws to allow medical marijuana, is the UM program still necessary?

    Answer:

    Yes. Purchasing or possessing marijuana products available in state dispensaries remains illegal at the federal level, although a number of states are working to facilitate research on the therapeutic benefits of marijuana and its constituent cannabinoids, and some have allocated funding from tax revenue for research. UM’s program provides materials for research that meet the legal and safety requirements of both DEA and FDA. Marijuana intended for scientific research must be standardized and meet certain quality requirements, which UM can guarantee based on its growing processes and adherence to the FDA’s Good Manufacturing Processes.

    Can UM analyze an external researcher’s marijuana samples?

    Answer:

    Yes, but only if the researcher maintains a DEA Schedule-I registration that allows transfer of materials between registrants.