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There’s currently insufficient human data to provide clear conclusions about the effects of CBD on progesterone and estrogen levels. A look into the potential effects of cannabis on women’s hormones and what it could mean for those who suffer from hormonal imbalances.

Does CBD Affect Progesterone and Estrogen?

Progesterone and estrogen are the primary female sex hormones. Both hormones play a critical role in regulating female reproductive systems and contribute to general wellbeing.

Emerging research suggests that cannabidiol (CBD) may modulate the expression of certain hormones, such as progesterone and estrogen. However, research exploring the effects of CBD on these hormones is still at a nascent stage, and findings are mixed.

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What Are Progesterone and Estrogen?

More than fifty hormones have been identified in the human body. Hormones are chemical messengers released by endocrine glands into the bloodstream, where they travel to receptor sites in the organs and tissues to trigger change. The master gland controls the function of most glands in the body, called the pituitary gland.

Men and women generally have the same hormones, although they occur in different quantities, are produced at various sites, and interact with organs and bodily systems differently.

Progesterone and estrogen are the most dominant hormones in women, while testosterone is the most prevalent hormone in men. However, men also produce progesterone and estrogen, albeit at lower levels. Progesterone and estrogen both play essential roles in men’s and women’s reproductive health.

Progesterone

Progesterone is a “precursor” or building block hormone that helps manufacture sex hormones, such as estrogen and testosterone. The ovaries secrete this essential hormone in women and the testes in men. In women, progesterone has the specific role of regulating menstruation and supporting female reproduction. In men, progesterone has the critical function of helping to produce testosterone and influences the production of sperm (spermiogenesis).

However, progesterone also contributes to some other vital physiological functions in both women and men, such as:

  • Regulating blood sugar.
  • Building bone mass.
  • Regulating brain activity.
  • Converting fat into energy.
  • Regulating thyroid production.
  • Sparking libido.
  • Balancing mood.
  • Helping support sleep.

Estrogen

There are three major forms of estrogen: estradiol, estrone, and estriol. Estradiol, the most predominant form of estrogen in men, influences erectile function, libido, and the production of sperm. In men, estrogens are primarily produced in the testes, adrenal glands, and the brain.

Estradiol is the most common form of estrogen in women during the reproductive years, contributing to the growth of the egg follicle in preparation for conception/menstruation, the thickness and health of the uterus, and the formation of breast tissue. Estrone becomes more prominent after menopause, while estriol is predominant during pregnancy. In women, estrogens are largely produced in the ovaries and adrenal glands.

In both men and women, estrogens can also help contribute to the following bodily processes:

  • Building bone density.
  • Facilitating physical changes during puberty.
  • Maintenance of mood and emotional state.
  • Healthy skin.
  • Cognitive function.
  • Muscle mass.
  • Metabolism.

CBD and Progesterone and Estrogen: What the Science Says

At present, insights into the effects of CBD on progesterone and estrogen are still very much in a nascent phase. Most existing research explores the effects of whole-plant cannabis (THC, CBD, other minor cannabinoids, terpenes, flavonoids, and other plant compounds) on hormones.

The interaction of these diverse compounds in cannabis with hormone production and expression is nuanced due to the entourage effect. It’s therefore difficult to conclude the effects of CBD from research that investigates the effects of whole-plant cannabis on progesterone and estrogen.

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Nonetheless, it’s clear that cannabis can modulate our hormones through its effects on the endocannabinoid system (ECS) and the cannabinoid receptors (which consist of the CB1 and CB2 receptors). The ECS plays a critical role in our immune system and contributes to the body’s homeostasis (balance and equilibrium). This critical bodily system also influences hormonal function.

Of the few studies that exist exploring the effects of CBD on estrogen.

A 1980 study found that moderate to high doses of CBD did not change the estrogen levels of female rhesus monkeys. However, a 2020 test-tube study found that CBD suppressed estrogen production by inhibiting the production of an enzyme called aromatase. Aromatase plays a vital role in the body’s production of estrogens. CBD was also found to deregulate decidualization, a process that plays a role in healthy pregnancies. The authors suggested that CBD could lead to infertility problems. However, large-scale clinical studies, including human participants, are needed before drawing any conclusion.

Findings on progesterone are also inconclusive. In a 2018 study, mice that received CBD for 34 consecutive days experienced no change in their circulating progesterone levels. In a 2005 study on rats, however, CBD inhibited the expression of progesterone in rat testes. The researchers suggested that the outcome may be caused by a metabolic interaction between the cannabinoid and the enzyme that converts progesterone into other hormones.

How to Use CBD to Balance Progesterone and Estrogen

Despite the ambiguous data concerning the effects of CBD on progesterone and estrogen, there is some research suggesting that CBD may counter hormone imbalance.

A 2022 study in an animal model of rat epilepsy showed that seizures are more frequent when estrogen levels are high, and progesterone levels are low – a period known as the proestrus-estrus transition. The researchers found that a single dose of CBD offered partial protection against the severity of seizures and inflammation that can occur due to high levels of estrogen. They also concluded that CBD could be used to support hormone balance when estrogen/progesterone levels are fluctuating.

In human populations, anecdotes abound about the hormone-balancing properties of CBD, even if clinical data is sometimes scarce. For example, CBD may yield benefits for women experiencing the fluctuations of menopause. Beyond CBD, there’s evidence that marijuana, in general, may help with menstrual cramps.

If you’re thinking about experimenting with CBD to balance estrogen and progesterone, it can be helpful to consult with a doctor experienced in cannabis medicine before beginning a new regime. For example, finding out if CBD may affect certain medications, such as birth control, is vital.

If you try CBD oil or other CBD products, check out our list of helpful dosing tips, and always remember to start low and slow.

The Bottom Line: Can CBD Help Balance Progesterone and Estrogen?

At this stage, there’s simply not enough robust data to suggest that CBD can support the hormonal balance of estrogen and progesterone.

The research has primarily been confined to test tube and animal studies or simply isn’t specific enough. For example, most of the available data explores the effects of the cannabis plant, THC, or marijuana use on hormonal imbalances, hormone levels, or the endocrine system in general, not on the effects of CBD on estrogen or progesterone specifically.

It’s likely, however, that the coming years will see more studies involving human participants, hopefully casting more light on how CBD influences the expression or production of estrogen and progesterone.

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Frequently Asked Questions

Does CBD affect any female hormones?

There’s definitely evidence to suggest that CBD can affect female-dominant hormones. However, at this stage, it’s unclear what the effects are on progesterone and estrogen, as the research findings have been mixed. There is data that suggests CBD affects other hormones, such as cortisol, stress, thyroid, or growth hormones.

Does CBD help with menstrual cramps?

Some emerging evidence suggests CBD (and weed in general) may help ease menstrual cramps and influence the menstrual cycle in general. CBD may also help manage symptoms associated with conditions such as endometriosis and polycystic ovarian syndrome.

Does CBD help with menopause symptoms?

CBD may also help soothe symptoms associated with menopause by potentially alleviating disrupted sleep, promoting a sense of calm and relaxation to overcome mood swings and hot flashes, regulating weight gain, stabilizing blood pressure, easing joint pain, and regulating blood sugar levels, elevating sex drive and promoting bone density.

Cannabis for Women: Does CBD Increase Estrogen?

May 9-15 is Women’s Health Week and the perfect time to discuss how cannabis can affect our bodies as women. While many focus on cannabinoids’ potential to help with pain, stomach distress, or a poor mood, some cannabinoids may assist with hormonal balance. We know that cannabis can impact our hormones, so does CBD increase estrogen levels?

Why is Estrogen Important to Women’s Health?

Estrogen is essential for a woman’s overall health and wellbeing. It helps regulate many body processes:

Regulate the menstrual cycle

Promote bone health

Protect against heart disease

Maintain healthy skin and hair

As we age, our estrogen levels naturally decline, which can cause menopause and many associated symptoms like hot flashes, night sweats, weight gain, and mood swings.

Does CBD Increase Estrogen Levels?

That’s a complex question. The endocannabinoid system (ECS) may play a role in hormonal balance, but research is still in its early stages. A study on male rats found CBD might decrease testosterone levels, but we need more research to say for sure how it affects female humans.

Studies show that the ECS plays a critical role in female reproductive health. Research demonstrates endogenous cannabinoids inhibit ovulation in female rats. The ECS may also be involved in menstrual cycle regulation by interacting with the hypothalamus, pituitary gland, and ovaries.

This isn’t enough information to make a definitive answer.

We have to leave CBD and estrogen as an open topic until we have more results.

CBD and ECS Balance

While we don’t know as much as we should about CBD, estrogen, and women’s health, there’s much more research and information from the scientific community about CBD and its ability to support endocannabinoid function. The ECS is vital to our health, and while there are many ways to encourage a healthy ECS, cannabinoids like CBD can help keep it in balance.

The benefits of CBD also help maintain symmetry within the body. Many people use CBD for a range of wellness needs, including:

CBD for Anxiousness

Anxiety and stress aren’t beneficial for your hormone levels. They can increase the production of cortisol, which can disrupt your menstrual cycle and make menopause more uncomfortable.

CBD may assist with relaxation and help to keep anxiety at bay. By keeping stress levels low, you may also be able to encourage a more regular menstrual cycle.

CBD for Sleep

Sleep is the best way to support your body and encourage hormonal balance. Our bodies produce growth hormones during sleep, essential for tissue repair, bone health, and regulating metabolism.

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CBD may help you get a better night’s sleep by interacting with the ECS to promote relaxation. A good night’s rest can also improve your stress levels and help control weight.

CBD for Inflammation

Our research shows chronic inflammation may increase the risk of endometriosis, PCOS, and ovarian cancer. It can also worsen menopause symptoms, like hot flashes and night sweats. CBD’s anti-inflammatory effects may help to ease pain and reduce swelling.

CBD for Skin Health

The skin is our largest organ, and it’s also full of cannabinoid receptors. When your hormones are out of balance, your skin may suffer. CBD’s potential to encourage cell regeneration and reduce inflammation may help improve the look and feel of your skin.

CBD may help to improve skin health by reducing inflammation and keeping the ECS in balance. A healthy ECS can promote cell growth and keep your skin looking its best.

CBD For Hair Health

A healthy scalp is vital for hair growth. CBD is a powerful antioxidant that can help to protect the hair from damage. It may also help to reduce inflammation and keep the scalp healthy.

CBD may help to improve hair health by reducing inflammation, keeping the scalp healthy, and encouraging cell growth.

CBD for Heart Health

Heart disease is the leading cause of death for women in the United States. A healthy ECS can reduce the risk of heart disease and support heart health. CBD may help protect the heart by reducing inflammation and keeping the ECS in balance.

CBD for Bone Health

Osteoporosis is a common problem for post-menopausal women. CBD may help to reduce inflammation and encourage bone growth. A healthy ECS may support bone health and reduce the risk of osteoporosis. Overall, strong bones are essential for a healthy body.

CBD to Manage Weight

CBD may help manage weight by reducing inflammation and keeping the ECS in balance. A healthy ECS can encourage cell growth and regulate metabolism. As the body loses estrogen, weight management becomes more difficult. CBD may help offset this weight gain by supporting a healthy ECS.

CBD for Gut Health

A healthy gut is vital for a healthy ECS. A healthy gut can reduce the risk of gastrointestinal problems and support gut health. CBD may help to reduce inflammation and keep the gut healthy.

CBD for Overall Wellness

CBD may help support overall wellness by reducing inflammation and keeping the endocannabinoid system in balance. A healthy endocannabinoid system can encourage cell growth and support the body’s natural ability to heal.

CBD may encourage hormonal balance through a healthy body by supporting the ECS.

Final Thoughts on Cannabis, CBD, and Estrogen

We need more research to say for sure how cannabis affects female hormones. We know that the endocannabinoid system regulates the menstrual cycle and ovulation. CBD may also help to reduce anxiety and inflammation and promote skin health.

If you’re considering using CBD, or any cannabis product, talk to your doctor first. They can help you understand how it might interact with any medications you’re taking and offer guidance on the best dosage for your needs.

Pantry Food Co. edibles are an excellent way to add CBD to your daily routine. Our cannabis bites are available in various flavors and make a wonderful mid-day or evening treat as part of your wellness plan. Check out our list of CBD edibles today!

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