Cbd oil for child seizures kpcc
Listen to story
As more states legalize marijuana, there’s growing interest in a cannabis extract — cannabidiol, also known as CBD.
It’s marketed as a compound that can help relieve anxiety — and, perhaps, help ease aches and pains, too.
Part of the appeal, at least for people who don’t want to get high, is that CBD doesn’t have the same mind-altering effects as marijuana, since it does not contain THC, the psychoactive component of the plant.
“My customers are buying CBD [for] stress relief,” says Richard Ferry, the retail manager of Home Grown Apothecary in Portland, Ore., where recreational marijuana use is legal under state law, with some restrictions.
Another rationale Ferry’s heard from clients about their CBD use: “Their mother-in-law is in town, and they just want to chill out!”
“CBD has gotten a lot of buzz,” Ferry says, as he displays an array of CBD products, including capsules and bottles of liquid CBD oil that users dispense under the tongue with a dropper.
By one estimate, the CBD industry has doubled in size over the last two years, and is now worth $200 million. But with this popularity the hype may have gotten ahead of the science.
A sample of cannabidiol (CBD) oil is dropped into water. Supplements containing the marijuana extract are popular and widely sold as remedies for a variety of ailments and aches. But scientific evidence that they work hasn’t yet caught up for most applications, researchers say. Stefan Wermuth/Bloomberg Creative Photos/Getty Images
“There’s a lot of confusion about how it [CBD] works and what it does exactly,” Ferry says.
Researchers now are trying to nail down CBD’s effects.
“I think there’s good evidence to suggest that CBD could be an effective treatment of anxiety and addiction” and other disorders, says Dr. Esther Blessing, a psychiatrist and researcher at New York University. “But we need clinical trials to find out.”
So far, evidence of the substance’s anti-anxiety effect comes from animal research and from very small, short-term human studies that suggest CBD exhibits anti-inflammatory and anti-anxiety properties.
The Marijuana Business Conference & Expo in Chicago in 2015 displayed oil containing CBD extracted from agricultural hemp. Today CBD oil alone is estimated to be a $200 million industry. Carla K. Johnson/AP
These preliminary findings piqued Blessing’s interest. For instance, she points to a 2011 study of a few dozen people, some of whom had social anxiety disorder, who were asked to speak in front of a large audience. Researchers compared anxiety levels in people after they took CBD, compared to those who got the placebo or nothing at all. (The participants didn’t know if they’d been given the drug or the placebo.)
And what did the scientists find? “People who took CBD reported significantly less anxiety” compared to those who got the placebo, Blessing says. “It’s really interesting.”
GW Pharmaceuticals makes Epidiolex, a medicine containing pharmaceutical-grade CBD. Last week, a panel of FDA advisers recommended approval of the drug to treat severe seizure disorders in children. Kathy Young/AP
Now, with funding from the National Institutes of Health, Blessing and group of collaborators are about to begin a clinical trial to test whether CBD can help people with post-traumatic stress disorder who also have moderate or severe alcohol use disorder.
During the study, 50 participants with PTSD coexisting with alcohol use disorder will be given either 400 milligrams of CBD daily, or a placebo. The goal is to see if the participants who take CBD end up drinking less and whether this leads to an improvement in PTSD symptoms. The participants will be given a pharmaceutical-grade CBD, which is more reliable in strength and purity than the supplements that are currently available for sale to the public.
Another Phase 2 clinical trial (to test efficacy and side effects) is exploring whether CBD might help prevent relapse in opioid abusers by reducing craving for the drug. The study’s led by Yasmin Hurd, a neuroscientist who directs the Addiction Institute at the Mount Sinai School of Medicine.
Hurd has been trying to rally other top scientists to study CBD’s effects and potential benefits in the treatment of substance abuse.
It may seem counterintuitive that a component of marijuana could be useful in treating addiction to another drug. But Blessing says using CBD is very different from using marijuana. Though CBD is extracted from cannabis, it does not lead to altered perception and cognition.
“Drugs can be non-psychoactive and still have an effect on the brain,” Blessing says. “CBD does have an effect on the brain, but it seems to affect the brain in possibly medicinal ways.”
Results from Blessing study are a few years off. But in the meantime, just last week, a panel of advisors to the Food and Drug Administration recommended approval of the first pharmaceutical grade CBD, called Epidiolex, to treat severe seizure disorders in children. This could open the door to more research to approve its use in other disorders.
Dr. Robert Carson is a pediatric neurologist at Vanderbilt University who has evaluated the effectiveness of CBD supplements in kids with seizures. He says the supplements can be beneficial for these children. However, he says, if the FDA follows its advisory panel’s advice and approves a pharmaceutical-grade CBD drug, that would open up a new treatment option by delivering a high-quality, consistent dose of CBD.
“One of the main caveats I tell my patients who use a CBD supplement is that we cannot guarantee what’s in it,” Carson explains. “We can’t guarantee the consistency.”
Supplements aren’t regulated as strictly as pharmaceuticals, and can vary widely from bottle to bottle or brand to brand.
And there’s another issue would-be users face: Though CBD supplements are widely available for sale, a legal murkiness surrounds marijuana extracts.
Even if you live in a state where marijuana use is legal, the federal Drug Enforcement Administration still classifies the CBD extract as a Schedule 1 substance — the DEA’s most restricted category. According to the agency, “Schedule I drugs, substances or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse.”
Proponents of CBD’s use in treating medical conditions and ailments hope the findings of studies now underway will help change that thinking about its legal classification — and its potential benefits.
Where To Drink Cannabis Cocktails In Los Angeles Right Now
Otium's Pineapple Express, made with Sipsmith gin, pineapple Campari and H. Hemp Company coconut CBD oil.
Start your day with LAist
C ould the marijuana martini become a staple on cocktail menus? Don’t be surprised. Bartenders are mixing CBD and terpenes — the compounds in cannabis that don’t get you high — with mezcal, gin, scotch, cachaça and pretty much every other kind of liquor to create drinks like the Stoney Negroni and the Rolled Fashioned.
Here in Los Angeles, Jason Eisner kicked off the trend in 2016 at Mexican vegan restaurant Gracias Madre. For him, it wasn’t a gimmick. It was a way to educate people about the health benefits of cannabidiol. while giving them a full-body buzz. The legalization of recreational marijuana means more bartenders have hopped on the bandwagon.
Although CBD doesn’t have the mind-altering effects of THC, you definitely need to be aware of how much you drink. And when I say “you” I mean “me.”
After baby sips of three Gracias Madre drinks, I felt as if I’d downed two full cocktails. But not in a falling-down drunk way, just feeling soooooo gooood and — bonus! — without the telltale signs of an impending hangover. Some people claim CBD can even soothe the downsides of drinking too much alcohol.
Want to experience the hottest trend in booze? Here’s where to go.
Employees Only LA
Like In & Out’s animal style fries or its 4×4 burger, Nice Dreams isn’t on the menu but if you know what’s up, you can order this secret concoction — and look ridiculously insidery while doing it. Bar manager Dee Ann Quinones’ adds CBD oil to mezcal for a subtly smoky and giggle-inducing drink.
- 7953 Santa Monica Blvd, West Hollywood
Although the Belgian pub is best known for its beer, assistant GM Lisanne Magnus fell in love with the flavors and homeopathic benefits of CBD. “CBD heightens feelings of relaxation and euphoria. Why wouldn’t I want to add it to a cocktail?” she says. In the Gentle Monk, she mixes gin with a CBD alcohol-based tincture, which integrates into a cocktail better than an oil.
- 13730 Ventura Blvd., Sherman Oaks
Instead of dropping CBD oil into a cocktail shaker, beverage director Pete Capella cooks it in a burned sugar syrup, which gives drinks a richer, smoother flavor. He serves CBD’d takes on classic drinks like the Pisco Sour and Penicillin.
- 8400 Wilshire Blvd., Beverly Hills
Broken Shaker's Pirate's Gold with cachaça, yellow chartreuse, avocado pit orgeat, germanium and thyme, lime juice, and Gold Flora CBD oil.
Broken Shaker at the Freehand Hotel
You’re on the Freehand’s roof, at its poolside bar, already entranced by the view of the downtown L.A. skyline. But you can still get higher. “I like to use CBD in cocktails, especially on the roof, because it’s all about adding to the vibe that you are feeling up there,” says bartender Christine Wiseman. Her Pirate’s Gold is a mix of cachaça and mood-lifting Gold Flora CBD oil.
- 416 W. 8th St., downtown L.A.
Gracias Madre's Stoned Fruit with black plum, yuzu, apricot liqueur, orange aperitif, cannabinoid, mezcal.
If you haven’t tried Jason Eisner’s OG pot cocktails, do it ASAP. The Stoney Negroni and Rolled Fashioned are coming off the menu in the next couple of months. Fortunately, the uber-popular Sour T-iesel will stick around along with bar director Maxwell Reis’s CBD-laced mezcal concoctions, the Stoned Fruit and Alternative Medicina.
- 8905 Melrose Ave., West Hollywood
The Rye Meow with rye whiskey, dry vermouth, elderflower and CBD oil.
Director of operations Jamie Boalbey said she was intrigued by CBD after reading about its health benefits for anxiety and epilepsy. Her Rye Meow, a riff on the Brooklyn, uses elderflower and rye to highlight CBD’s earthy qualities.
- 801 N. Fairfax Ave. #101, Los Angeles
Otium's Blue Dream: Rhum Clement VSOP, Casa Magdalena Rum, lime, vanilla orgeat, Giffard Blue Curacao and H. Hemp Company coconut CBD.
Bartender Chris Amirault likes the way CBD works with citrus but he thinks it changes the texture of stirred drinks, so he adds vanilla syrup to his Pineapple Express, a CBD-spiked Negroni. That helps maintain that silky but weighty mouthfeel of a traditional Negroni. Amirault also serves the Blue Dream, an azure Mai Tai variation he created for 4/20. If you’re not feeling either of those, you can add CBD oil to any cocktail for $5.
Cbd oil for child seizures kpcc
October 7, 2020 Study Finds Older Adults Using Cannabis to Treat Common Health Conditions
Michelle Brubaker and Scott LaFee, UC San Diego Health Newsroom
August 1, 2020 Cognitive and Emotional Sequelae of Cannabis Use – With Dr. Igor Grant
John Bellone and Ryan Van Patten, Navigating Neuropsychology podcast
February 26, 2019 Can CBD Help Your Child?
Rachel Rabkin Peachman, Consumer Reports
January 16, 2017 When Are You Too Stoned to Drive?
Beth Schwartzapfel, The Marshall Project
January 15, 2017 Stoned Driving: How can police tell?
Reed Pence, Radio Health Journal
October 30, 2016 High on the highways?
Tom Relihan, The Recorder
August 12, 2016 DEA Says Pot to Remain Illegal Drug
Rob Hotakainen, The San Diego Union Tribune
August 11, 2016 DEA moves to make more marijuana available for medical research
Peter Hecht and Christopher Cadelago, The Sacramento Bee
May 13, 2016 UCSD to Study Effects of Marijuana on Driving
Megan Tevrizian and Laura McVicker, NBC San Diego
February 14, 2015 Is Cannabis the New Frontier of Therapeutics?
American Association for the Advancement of Science
November 20, 2014 PBS Second Opinion – Medical Marijuana
PBS Second Opinion Series, Episode 1106
October 8, 2014 Legalizing Marijuana: The Public Health Pros and Cons
The Forum at Harvard School of Public Health
November 10, 2013 Young Utahn opts for cannabis to treat cancer
Kirsten Stewart, The Salt Lake Tribune
September 27, 2010 Health Effects of Marijuana
Megan Burke & Maureen Cavanaugh, KPBS
February 18, 2010 Clinical trials show medical benefits of pot
Victoria Colliver & Wyatt Buchanan, San Francisco Chronicle
February 17, 2010 Study Proves Pot is Good Medicine
Jessica Greene, NBC Bay Area
January 18, 2010 Is Marijuana a Medicine?
Anne Wilde Matthews, Wall Street Journal
August 4, 2009 Does the Pot Pill Work?
Brian Montopoli, CBS News
August 6, 2008 Medical Marijuana Works for HIV-Related Nerve Pain, Study Says
Elizabeth Lopatto, Bloomberg
February 13, 2007 UC study: Pot May cut nerve pain
Carrie Peyton Dahlberg, Sacramento Bee
February 12, 2007 Smoked Cannabis Reduces Pain Caused by Peripheral Neuropathy
Press Release, University of California, San Francisco
June 12, 2005 Scientifically Speaking, This Drug’s on the Wrong List
Editorial By Daniele Piomelli in the Washington Post
June 8, 2005 Ailing Users Loyal to Pot: Despite High Court’s Ruling, They See No Alternatives
Lesli A. Maxwell and Edie Lau, Sacramento Bee
June 7, 2005 Science Murky on Drug’s Effects: Is it More Effective Than Medications?
Byron Spice, Pittsburgh Post-Gazette
March 28, 2004 Family remedy: Shelly Arnold’s home-grown answer to her son’s pain tests the acceptance of medical marijuana
Will Evans, Sacramento Bee
November 24, 2003 Reefer Sanity, The brain’s cannabinoid is the target of a rush (ha!) to develop new drugs
Meredith Wadman, Fortune Magazine
June 27, 2003 Study: Pot Doesn’t Cause Permanent Brain Damage
Deena Beasley, Reuters Health E-Line
June 27, 2003 Study: Pot doesn’t hurt thinking skills
Jenny Diamond, San Diego Union Tribune
May 1, 2003 The Myth of “Harmless” Marijuana
John P. Walters, The Washington Post
April 14, 2003 Marijuana Compounds May Act Without Causing High
Jacqueline Stenson, Reuters Health
February 2003 Medical Marijuana
Heather Bentley, San Diego Physician
October 27, 2002 Is Pot Good For You?
John Butt, Time.com
October 14, 2002 Marijuana study tries to bring facts to heated debate
Linda Marsa, The Los Angeles Times (latimes.com)
March 5, 2002 Segment from NPR’s All Things Considered titled, “Marijuana and the Brain”
Articles discussed in the segment:
Cannabis, Cognition, and Residual Confounding
Cognitive Functioning of Long-term Heavy Cannabis Users Seeking Treatment
December 16, 2001 Letter to the NYT Editor
Igor Grant, M.D., CMCR Director
December 15, 2001 Cannabis research to start early next year
Philip J. Hilts, New York Times
November 28, 2001 CMCR receives DEA approval for 2 studies
Press Release, University of California
June 25, 2001 The Supreme Court ruling against manufacturing and distributing medicinal cannabis exempts research
A.J.S. Rayl, The Scientist
February 22, 2001 CMCR approves research studies
Press Release, University of California
August 29, 2000 CMCR established at the University of California
Press Release, University of California