cbd oil for chronic idiopathic urticaria

Study to Evaluate the Safety, Tolerability and Efficacy of Cannabidiol (CBD) as a Steroid-sparing Therapy in Chronic Spontaneous Urticaria (CSU) Patients

Each patient will commence the study with a one month run-in period in which he/she will be administered individual patient Standard of Care :anti-histamines and steroids as needed plus placebo (olive oil).

After the run-in period, doses of CBD will be incresed during the first six weeks of the study.

At the conclusion of the six weeks CBD dose escalation segment of the study, if the 300 mg CBD dose level is deemed safe for two weeks with standard of care doses of anti-histamines, patients will continue receiving 300 mg CBD with Anti-histamines as needed for an additional follow-up period of three month.

Each patient will serve as his/her own control.

Condition or disease Intervention/treatment Phase
Chronic Spontaneous Urticaria Drug: CBD Phase 2

Each patient will commence the study with a one month run-in period in which he/she will be administered individual patient Standard of Care :anti-histamines and steroids as needed plus placebo (olive oil).

At the end of the one month run-in period, all trial subjects will continue on individual Standard of Care plus increasing doses of CBD during the first six weeks of the study. Dosage of CBD will start at 25 mg twice daily and will be increased once every 14 days, if no side effects are observed, to 50 mg twice a day, 100 mg twice a day and finally to 150 mg twice a day CBD respectively. Treatment will be given with food.

At the conclusion of the six weeks CBD dose escalation segment of the study, if the 300 mg CBD dose level is deemed safe for two weeks with standard of care doses of anti-histamines, patients will continue receiving 300 mg CBD with Anti-histamines as needed for an additional follow-up period of three months. In the case of flare, the patient will be treated with higher dose of Anti-histamines and Steroides if needed in addition to CBD. Once the flare has been brought under control, then another attempt will be made to discontinue the steroids and continue treating with CBD + Anti-histamines only. Each patient will serve as his/her own control.

Laboratory studies will be carried out at the beginning of the study (baseline), and then on a monthly basis until the end of the study.

How can CBD relieve hives?

We estimate at 20% of the population who develops, at some point in their life, a flare-up of hives. Sometimes it is a isolated episode, others of a chronic hives (0,5 to 2% of the population) which appears and disappears regularly on the skin of people with pain, leaving them little respite. Renowned for its calming, anti-inflammatory and soothing effects on the skin, cannabidiol (CBD) now gives new hope for a treatment. We see in this article how CBD can help relieve hives and what we know about the use of the cannabinoid on this kind of skin problem.

What is urticaria?

Urticaria is an “old” disease, in the sense that it has been known for a very long time and is easy to diagnose. However, it remains relatively poorly understood and difficult to cure, that this is in view of the appropriate treatment but also of the identification of the cause of the appearance of the urticaria outbreaks. Thus, many people with hives still have a hard time actually managing their seizures, and therefore live comfortably with their pathology. Allergists and dermatologists are then always of good advice, advice which is not necessarily sufficient to benefit from a satisfactory solution.

On the side of the manifestation of symptoms, we always find Rashes, usually accompanied by itching and papules : red and thick patches reminiscent of nettle bites. Joint pain, digestive problems and a slight fever can also accompany the appearance of plaques on the skin, more rarely edema.

Causes of a hives flare

The causes of urticaria remain relatively poorly understood. They seem in any case very large and of varied origins:

  • Food: especially after consumption of eggs, milk, nuts, fish and seafood, red fruits or chocolate.
  • Medication: taking aspirin, certain antibiotics, non-steroidal anti-inflammatory drugs (ibuprofen in particular), codeine, anesthetics, etc.
  • Environment: insect bite, certain soaps and cosmetic products, jewelry (especially containing nickel), latex.
  • Mental Health: stressful times mainly.

In most cases, however, the trigger is not the real cause of the onset of urticaria, but indeed an element encouraging its appearance. The real cause for its part remains very difficult to identify, which does not prevent having to treat the crisis as quickly as possible in order to avoid discomfort.

CBD and urticaria: a winning combination?

In the best-case scenario, a flare-up of hives will go away quickly by taking antihistamines. A few hours, at most a few days, are then enough to allay a crisis. When this is not enough, for example if the plaques spread over a large part of the body or affect the face, oral corticosteroids (corticosteroids) should be taken.

The corticosteroid problem

Corticosteroids are formidable in the face of many skin and / or allergy problems. Urticaria is no exception and responds very well to treatment with cortisone. The molecule is indeed ideal for stopping inflammation. It also belongs to the family of steroidal anti-inflammatory drugs.

The problem is that it is far from devoid ofSide effects. These include:

    ,
  • Water retention,
  • Digestion problems ,
  • Nervousness,
  • Depressed state,
  • Blood pressure problems (usually hypertension).

Some of these side effects are also found when taking antihistamines, which can cause weight gain, a feeling of drowsiness or heart risk disorders. The search of’alternatives to conventional treatments against urticaria thus represents a real hope for all those who suffer from it.

The hope of CBD products to relieve hives

It’s no longer a secret to many people, cannabidiol has virtuous effects on the skin and therefore stands out as an ally of choice when it comes to relieving certain pains and certain skin irritations. The market therefore already offers many products taking advantage of effects of CBD on the skin :

    : CBD oil helps regulate sebum levels and thus reduce the appearance of pimples. : they hydrate the skin and offer some protection against UV rays. : they deeply hydrate the skin, soothe skin irritations and reduce muscle tension. : they hydrate the skin and restore cellular tone to the skin.

Thus, cannabidiol in general and CBD oil in particular exhibit virtuous effects on the skin, which do not seem very far from what one seeks to obtain in the context of the treatment of urticaria. And therefore constitute a real hope.

In the specific case of urticaria, the lack of in-depth research, however, still leaves room for uncertainty.

Treatment of urticaria with CBD: what we know

The bad news for anyone who suffers from hives is that, at the time of this writing, there is not enough scientific data to draw definitive conclusions about the direct influence of CBD on the body. urticaria. However, there is some good news to offset this. We know in particular that CBD has and calm skin beautiful and well proven. It is also known that it is capable, in topical use (local, directly on the skin), ofsoothe certain irritations and D’moisturize the skin.

To date, therefore, it seems far-fetched to claim that cannabidiol can treat hives. What is not unreasonable is to seriously consider thecomfort that it can bring in direct application, in particular by reducing the discomfort related to itching or the burning feeling related to hives. Huge benefit of CBD, it doesn’t lead to no noticeable side effects and is very easy to apply and penetrate : a huge plus when the skin is irritated.

CBD for CIU aka urticaria aka chronic hives?

I have been diagnosed and living with mild CIU (chronic idiopathic urticaria aka chronic hives with no known cause) with angioedema (swelling) for almost 3 years now. Terrible thing to live with although it could be worse. It covers my body from head to toe during a flare up. Luckily I can control it with Allegra about 2-3 daily. Im looking to ditch the meds and just ordered 500mg 15ml full spectrum CBD oil from cbdistillery. I was wondering if anyone with the same condition has treated CIU with CBD treatment and the status of your condition. Is it any better/worse? Are you off meds? Also, anyone who wants to chime in on this product and what you use it for would be interesting and helpful as well. Thanks in advance!

If there is a better subreddit please direct me. This is my first post on Reddit. Thanks again!

I have been living with hives my whole life, so I know the pain. Here is a list of things that I have done to lessen how often I breakout with hives: check out high histamine diet. I eliminated artificial flavors and colors, aged & cured meats, fermented foods, I eat mostly organic. I don't use any chemicals to clean my house or clothing. all of these have helped as I hardly ever have hives but still get itching if I don't take clartin every day. I have started using 20 mg CBD twice a day on August 18. 2017 and have not noticed any change so far .

The itching used to keep me up at night but I use about .5 g marijuana for sleep so the itching isn't a problem at night anymore.