cbd oil for endocrine system

The effects of cannabinoids on the endocrine system

Cannabinoids are the derivatives of the cannabis plant, the most potent bioactive component of which is tetrahydrocannabinol (THC). The most commonly used drugs containing cannabinoids are marijuana, hashish, and hashish oil. These compounds exert their effects via interaction with the cannabinoid receptors CB1 and CB2. Type 1 receptors (CB1) are localised mostly in the central nervous system and in the adipose tissue and many visceral organs, including most endocrine organs. Type 2 cannabinoid receptors (CB2) are positioned in the peripheral nervous system (peripheral nerve endings) and on the surface of the immune system cells. Recently, more and more attention has been paid to the role that endogenous ligands play for these receptors, as well as to the role of the receptors themselves. So far, endogenous cannabinoids have been confirmed to participate in the regulation of food intake and energy homeostasis of the body, and have a significant impact on the endocrine system, including the activity of the pituitary gland, adrenal cortex, thyroid gland, pancreas, and gonads. Interrelations between the endocannabinoid system and the activity of the endocrine system may be a therapeutic target for a number of drugs that have been proved effective in the treatment of infertility, obesity, diabetes, and even prevention of diseases associated with the cardiovascular system.

Keywords: CB1 receptor; cannabinoid system; endocannabinoids; endocrine system.

The Effects of Cannabinoids on the Endocrine System

Fatigue, chronic stress, and burnout are the hallmarks of our on-the-go society. You feel tired all the time, but have trouble sleeping. When you do finally get some sleep, you wake up still tired. It may not be the amount of sleep you get. Chronic fatigue, mood disorders, dry skin, and other ailments may be signs that there is trouble with your endocrine system. What can you do to remedy these problems? Recent studies have shown the use of cannabinoids effects on the endocrine glands. Cannabis can be a viable holistic treatment for endocrine disorders.

A structure of connected glands, the endocrine system affects every cell and organ in the body. These glands secrete hormones that help cells communicate with each other by their molecules attaching to receptors. Throughout our bodies, there are many receptors. They relay information about what’s going on inside and outside of our bodies. The data goes to other sources that react and cause changes creating homeostasis, an equilibrium within our internal environment. If something is not right with that communication, it creates an imbalance. The imbalance is what can cause diseases and disorders.

Another network that works with the endocrine glands is the endogenous cannabinoid system. Also referred to as endocannabinoid, the system creates chemicals that are similar to those found in marijuana plants. Compounds that are created by the endocannabinoid system bind to what are called CB1 and CB2 receptors. When specific molecules combine with the CB1 and CB2 receptors, the effects are very similar to marijuana. Just like cannabis, reactions in the endocannabinoid systems have shown to affect functions dealing with appetite and digestion, pain response, immune function, inflammation, mood, memory, sleep, motor control, muscle and bone growth, and stress response. Other systems can cause changes in include the nerve, skin, cardiovascular, and reproductive systems. Marijuana as a plant-based substance can be a viable option to treat and reduce the symptoms of various disorders of the endocrine system.

Endocrine System Glands

Although there are many throughout our bodies, there are several primary glands in the endocrine system. These include the pituitary, thyroid, parathyroid, pineal, adrenal, pancreas, ovaries, and testicles. Cannabis has been shown to relieve symptoms in issues with the thyroid and pineal glands.

Pituitary Gland

The pituitary gland is considered the master gland. It works in conjunction with the hypothalamus, which is part of the brain. The hypothalamus decides which hormones the pituitary gland should release. It does this by sending hormonal or electrical messages. Hormonal messages make the pituitary release one of several hormones including GH (Growth Hormone), THS (Thyroid-stimulating hormone), FSH (follicle-stimulating hormone), LH (Luteinizing hormone), and Prolactin. Electrical messages from the hypothalamus cause the pituitary gland to release ADH (antidiuretic hormone) and oxytocin

Thyroid Gland

The thyroid is a butterfly-shaped gland below Adam’s apple in the front of the windpipe. It has two side lobes connected by the Isthmus. The thyroid gland has several vital functions. It regulates metabolism, generates body heat, breaks down food into nutrients and turns them into energy. It works relentlessly to create balance in the systems of the body.

Symptoms of an imbalance in the thyroid gland include hair loss, dry skin, chronic fatigue, and mood disorders. Problems with our thyroid can cause goiter, hyperthyroidism, grave’s disease, and thyroid cancer. The use of CBD oil and thyroid medications can help reduce the symptoms of these diseases and disorders.

Both Cannabidiol, also known as CBD, and thyroid chemicals work to restore balance to the gland. CBD and thyroid hormones attach to and cause similar reactions in both the CB1 and CB2 receptors. The healing qualities found in CBD can help relieve symptoms of thyroid disorders. CBD is the non-psycho active component found in the cannabis plant. Used for centuries as a medicinal, CBD has shown the ability to help relieve symptoms of thyroid disorders such as anxiety, irritability, pain, and inflammation. CBD oil and thyroid chemicals also react similarly. Using CBD-oil infused topical products is a safe and easy way to use cannabis to treat skin disorders due to thyroid issues.

Marijuana and the Pineal Gland

The Pineal Gland is a small, pinecone shaped gland in the center of the brain between the brain’s two hemispheres. It produces the hormone melatonin. This is the primary hormone that regulates our ability to sleep. CBD with Marijuana and the pineal gland hormones may be able to help rebalance any imbalance that causes sleep disturbances. Strains of the cannabis plant have different levels of THC (Tetrahydrocannabinol). This is the chemical that causes the user to get high. It can affect sleep patterns. Used in conjunction with CBD, THC can be used to control sleep patterns. Use of certain strains of cannabis and the pineal gland hormones already in the body can help a user to either sleep more or less depending on their sleep issues.

Adrenal Glands

There are two adrenal glands, one located on top of each kidney. They produce essential hormones that make it possible for us to function in our everyday lives. Cortisol is the primary hormone. One of its main functions is to help us to respond to stress. Adrenal fatigue is a common non-specific disorder of the glands. It’s not a medical condition, but a symptom of other possible disorders. The main signs of adrenal fatigue are chronic pain, fatigue, irritability, sleep, and digestive problems. Any medications, including marijuana, can cause a disruption in the adrenal glands.

Marijuana and Adrenal Fatigue

Marijuana and adrenal fatigue go hand in hand. Just like prescribed drugs, the THC in marijuana can disrupt functions in the adrenal gland. On the other hand, cannabis products without THC or low amounts don’t appear to cause the same kind of problems. Marijuana and adrenal fatigue can be combined if you use cannabis products with CBD, instead of THC.

If you have problems involving the endocrine system, cannabis may help. CBD and CBD oil has many healing qualities that can reduce symptoms such as pain, fatigue, and anxiety. On the other hand, cannabis products with high THC may make symptoms of adrenal fatigue worse. Before treating yourself, enlist the help of medical marijuana doctors that specialize in disorders of the endocrine system and are trained in functions of the endogenous cannabinoid system.

Hormone Balance Blend Oil

Nurture your hormonal health and support premenstrual or menopausal symptoms long-term. Our Balance Blend is packed with 600mg of CBD and provides functional servings of natural botanicals to support your endocrine system, aka mood and metabolism. Use it twice daily to find mental and physical balance during your period.

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A peek inside the Hormone Balance Blend


Cannabinoids are the compounds within hemp flowers that offer functional support for our body’s endocannabinoid systems (ECS).



Terpenes and cannabinoids work together in maximizing the effects of one another to help support stress, balance, mood health, and beyond.

Caryophyllene, Humulene, Eucalyptol


A potent infusion of organic and wildcrafted botanicals infused with specialty oils to support hormone balance and healthy tissue.

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MCT coconut oil

MCT is the carrier oil for the full spectrum hemp, which maximizes the extract’s bioavailability for maximum absorption. Antibacterial and antiviral, this supercharged oil rich in essential fatty acids helps balance gut flora to support immune health and increase serotonin levels for elevated mood. Certified organic.

evening primrose oil

A powerfully healing antioxidant, this fatty acid rich oil reduces inflammation and promotes balanced hormones. Certified organic.

Essential for optimal health, this nutrient dense oil contains the ideal blend of balancing minerals, healing antioxidants, nourishing fatty acids, and revitalizing vitamins to work wonders on the skin. Certified organic.

Used in Eastern cultures since ancient times, this phytonutrient dense cure-all helps with everything from breast pain to skin issues. Certified organic.

red raspberry leaf

A staple of traditional medicine, this wondrous botanical tones and nourishes the uterus for a healthy pelvic floor and reduces menstrual pain. Certified organic.

Full of essential phytonutrients, this iron-rich botanical gently cleanses and purifies the body to balance hormones and reduce fatigue. Certified organic.

milky oats & oatstraw

Calming and soothing, this ancient grain reduces anxiety and stress while promoting sexual health by nourishing the endocrine system and regulating hormones. Certified organic.

red clover blossom

Packed with isoflavones that mimic estrogen, this balancing botanical minimizes hormonal shifts that cause mood swings. Certified organic.

A natural diuretic and liver cleanser, this nutrient rich botanical helps relieve bloating and swelling caused by water retention. Certified organic.

A powerful medicinal plant, this lemon scented herb has been shown to reduce mood problems and sleep disturbances associated with premenstrual pain and discomfort. Certified organic.

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Chock full of premium CBD and a full spectrum of active cannabinoids, terpenes, flavonoids, and trichomes, this full spectrum hemp oil nourishes the endocannabinoid system to offer functional support for stress, sleep, inflammation and balance.

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If you’re thinking about it, I recommend you just give it a try. Great price for a natural product that actually makes a noticeable difference. Lovely packaging as well!

I’m so happy to have found Ned and this particular product. It is working to gently balance my hormones while transitioning from my old hormone balancers to this new one. It feels like nature not medicine. I love this product!

I’ve loved every Ned product I’ve tried and Hormonal balance is no different! All of their CBD has helped me with anxiety and insomnia and this blend has been helpful with the hormonal cystic acne I’ve been getting. Thanks for a great product!

Got questions? We’ve got answers.

How Does CBD Hemp Oil Affect Hormones?

Hemp oil for hormonal imbalance has not been well researched to date. However, research suggests that due to the effects of various hemp cannabinoids like CBD on our body’s endocannabinoid system, hemp oil and hormones may be closely connected.

The system responsible for maintaining natural hormone balance is the endocrine system. The endocrine system is our body’s network of hormone glands and its workings are modulated by the endocannabinoid system. Thus, by interacting with our body’s endocannabinoid system, hemp oil is thought to exert indirect beneficial effects on hormone balance.

The endocrine and endocannabinoid systems are both chemical messenger systems responsible for maintaining homeostasis or whole-body balance. Preliminary studies suggest that CBD administration may lead to attenuated levels of the stress hormone cortisol and improved insulin production. CBD has also been linked to modulating serotonin, dopamine, and melatonin.

How Does the Hormone Balance Blend Oil Promote Natural Hormone Balance?

Ned’s hormone balance oil blend is formulated from a potent infusion of organic full spectrum hemp, 600 mg of premium CBD, and powerful botanicals including evening primrose oil, chia seed oil, black seed oil, red raspberry leaf, stinging nettles, milky oats & oatstraw, red clover blossom, dandelion leaf, and lemon balm.

Ned’s Hormone Balance Blend ingredients contain important phytonutrients, essential fatty acids, vitamins, minerals, isoflavones that mimic estrogen, and have unique therapeutic properties that have been linked to promoting natural hormone balance. Some of these properties include antioxidant, anti-inflammatory, anxiolytic, and cleansing effects that promote whole body balance.

How often should I take the Hormone Balance Blend Oil?

The Hormone Balance Blend Oil is designed to be used daily throughout the entire month.