cbd oil for extreme pain with or without thc

CBD Oil for Pain

Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.

Lana Butner, ND, LAc, is a board-certified naturopathic doctor and licensed acupuncturist in New York City.

For many people experiencing chronic pain, cannabidiol (CBD) oil is steadily gaining popularity as a natural approach to pain relief. A compound found in the marijuana plant, cannabidiol is sometimes touted as an alternative to pain medication in the treatment of common conditions like arthritis and back pain.

The use of cannabis for pain relief dates back to ancient China.   It’s thought that CBD oil might help ease chronic pain in part by reducing inflammation. In addition, CBD oil is said to promote sounder sleep and, in turn, treat sleep disruption commonly experienced by people with chronic pain.  

It’s important to note that many CBD oil products do not contain tetrahydrocannabinol (THC), the compound responsible for producing the “high” associated with marijuana use. Unlike THC, cannabidiol is non-intoxicating and does not have psychoactive effects.

Why People Use CBD Oil

According to the Institute of Medicine of The National Academies, 100 million Americans live with chronic pain. Along with drastically reducing quality of life, chronic pain can increase healthcare costs and have a negative impact on productivity at work.

Common types of chronic pain include:

Over-the-counter (OTC) and prescription pain medications are often recommended in the treatment of chronic pain, but many people seek out alternative forms of relief, such as herbs, nutritional supplements, and products like CBD oil.

Some of these people wish to avoid the side effects frequently associated with standard pain medication, such as damage to the liver and kidneys, while others have concerns about becoming dependent on such medications.

Some proponents suggest that CBD oil could provide a solution to opioid addiction as concerns over opioid overdoses continue to escalate.

Potential Benefits of CBD Oil

Scientists are still trying to determine how CBD oil might alleviate pain. However, there’s some evidence that cannabidiol may affect the body’s endocannabinoid system (a complex system of cell-to-cell communication). Along with contributing to brain functions like memory and mood, the endocannabinoid system influences how we experience pain.

When taken orally, CBD has poor bioavailability. Topical CBD application to localized areas of pain appears to provide more consistent levels of CBD with less systemic involvement.

Animal-Based Research

So far, much of the evidence for CBD oil’s effects on pain management comes from animal-based research. This research includes a study published in the journal Pain in 2017, in which scientists observed that treatment with topical CBD helped thwart the development of joint pain in rats with osteoarthritis.

Another study, published in the European Journal of Pain in 2016, found that topical CBD gel significantly reduced joint swelling and measures of pain and inflammation in rats with arthritis.  

Epidermolysis Bullosa

In a report published in Pediatric Dermatology in 2018, scientists reported three cases of topical CBD (applied as an oil, cream, and spray) use in children with a rare, blistering skin condition known as epidermolysis bullosa.  

Applied by their parents, all three people reported faster wound healing, fewer blisters, and improvement of pain. One person was able to completely wean off oral opioid analgesic pain medication. There were no adverse effects reported.

Chronic Neuropathic Pain

While very few clinical trials have explored the pain-relieving effects of CBD oil, a report published in the Cochrane Database of Systematic Reviews in 2018 examined the use of a variety of cannabis-based medicines and found they might be of some benefit in the treatment of chronic neuropathic pain.  

A type of pain triggered by damage to the somatosensory system (i.e., the system responsible for processing sensory stimuli), neuropathic pain often occurs in people with conditions like diabetes and multiple sclerosis.

In this report, researchers reviewed 16 previously published studies testing the use of various cannabis-based medicines in the treatment of chronic neuropathic pain and found some evidence that cannabis-based medicines may help with pain relief and reduce pain intensity, sleep difficulties, and psychological distress.

Side effects included sleepiness, dizziness, and mental confusion. The authors concluded that the potential harm of such medicines may outweigh their possible benefit.

However, it should be noted that the studies used a variety of cannabis-based medicines (e.g., inhaled cannabis, sprays, and oral tablets containing THC and/or CBD from plant sources or made synthetically), some of which are more likely to result in these side effects than products without THC.

Side Effects and Safety

The research on the side effects of CBD oil is extremely limited. CBD is the major non-psychoactive component of cannabis. Due to the lack of regulation, there is inconsistency in content and purity. The amount of CBD may not be consistent, and products can contain varying amounts of the psychoactive component THC.

In studies using varied doses, routes of administration, and combination or whole products with THC, a number of side effects have been reported. These include anxiety, changes in appetite and mood, diarrhea, dizziness, drowsiness, dry mouth, low blood pressure, mental confusion, nausea, and vomiting.  

There’s also some concern that taking high doses of cannabidiol may make muscle movement and tremors worse in people with Parkinson’s disease.

What’s more, CBD oil may interact with certain medicines, such as medications changed by the liver (including chlorzoxazone, theophylline, clozapine, and progesterone) and sedative medications (including benzodiazepines, phenobarbital, fentanyl, and morphine).

When smoked, cannabis has been found to contain Aspergillus (a type of fungus).   People with suppressed immune systems should be aware of the risk of fungal infection when using this form of cannabis. Topical CBD application may also cause skin irritation.

CBD oil should not be used as a substitute for standard care. In the case of chronic inflammatory conditions like arthritis, for instance, chronic inflammation can lead to joint damage (causing destruction and disability) if the condition is not effectively managed.

Availability of CBD Oil

As more and more states across the U.S. legalize the use of marijuana, CBD oil has become more widely available. CBD oil is now sold in a range of forms, including capsules, creams, tinctures, and under-the-tongue sprays.

While many companies now sell CBD oil online and in dispensaries, use of the oil isn’t legal in every state. Because state laws vary greatly when it comes to cannabis products, it’s crucial to confirm that use of CBD oil is legal in your state.


Chronic pain is the most common reason for medicinal cannabis use, according to a recent survey.   If you have a chronic pain condition and have not been able to manage it with standard treatment (or wish to avoid the adverse effects of other medications), you may be considering CBD oil for pain relief.

Preclinical animal research suggests that CBD may have moderate pain-relieving effects for neuropathic pain without the cannabinoid-like side effects, however, there is currently a lack of large, well-designed clinical trials (the type of research you want to see to put full stock in a treatment) confirming these effects.

If you're thinking of trying CBD oil for pain relief (and it is legal where you live), talk to your healthcare provider to discuss whether it's appropriate for you and the safest way to incorporate it into your pain management plan. Keep in mind that due to the lack of regulation, the purity and content of CBD oil products can vary.

A Word From Verywell

If you live with chronic pain, you may have experienced how it can disrupt sleep and, in some cases, can contribute to anxiety and depression. Natural and lifestyle therapies, such as exercising and taking up mind-body practices like meditation and yoga, as well as following an anti-inflammatory diet may help improve quality of life for some people who experience pain regularly.

Best CBD Gummies For Pain Inflammation: Top Hemp Edibles Review (2021)

Chronic pain affects over 50 million Americans, which makes for more than 20% of the entire US population. However, many people dealing with chronic pain are also not satisfied with prescribed meds and over-the-counter painkillers and are searching for alternative solutions. For this reason, we are going to explore the best CBD gummies for pain treatment we can find in 2021.

CBD-infused gummies are a delicious and handy way of finding relief from pain. These little fruity treats contain a precise dose of CBD oil and are inconspicuous enough to pass for ordinary candy. Moreover, they don’t leave the unpleasant aftertaste as CBD oils do. So, if you are looking for something you can take on the go or in public places, or you just can’t stand the specific hemp taste, CBD edibles might be the perfect option.

Another bonus is that most CBD gummies do not contain THC, an ingredient that makes marihuana users feel high. So, you can reap all the benefits the hemp plant has to offer and still go about your day and work the usual way.

All these qualities make gummies a popular choice among those looking for pain relief in CBD products. However, in the competitive CBD market, not every product is of the same quality. So, if you want to buy a product worth your money and get the desired results, check out our list of the best CBD gummies for pain relief we can find in 2021.

Top 10 Best CBD Gummies For Pain & Inflammation

  1. Royal CBD — the best, award-winning CBD gummies for pain
  2. Gold Bee — second place, good quality, affordable price
  3. Blessed CBD
  4. Tasty Hemp Gummies
  5. CBDfx
  6. cbdMD
  7. Charlotte’s Web
  8. Plus CBD
  9. Medterra
  10. Joy Organics

Let’s discuss the edibles these companies offer in more detail.

1. Royal CBD Gummies — The Best CBD Edibles For Pain

Anyone using CBD goods has heard of Royal CBD. This amazing company has only been around for a couple of years but has already made a name for itself. Founded in 2017, Royal CBD decided that transparency is the best policy. So, this company has made everything about the ingredients and production process open to scrutiny.

Royal CBD uses a quality, organic, locally-grown hemp and a supercritical CO2 extraction method. The end result is a premium quality, award-winning product, making it a top-rated brand by reputable online publications such as CFAH, Observer, We Be High, and many others. And if you need more proof, the company also provides third-party lab testing for every batch. Hence, we can check the potency and quality of every Royal CBD product we buy.

As far as variety goes, this company doesn’t offer too many different options. However, we can still find the classics, such as CBD oils, capsules, honey sticks, and gummies on the Royal CBD’s website.

However, our research has shown Royal CBD makes the best CBD gummies for pain on the market. The company uses the best quality hemp plant and premium gummy base. Moreover, it extracts THC and what remains is a broad-spectrum CBD extract. Broad-spectrum means that the product has all other cannabinoids, such as CBC, CBN, CBG, THCV, except for THC.

So, if you weren’t sure about using CBD edibles because of work-related drug tests, you can rest assured. CBD gummies won’t show on our blood work but will provide excellent pain relief.

Royal CBD gummies come in a 30-piece container and various fruity flavors. Also, you can choose between two different potencies. The lower potency edibles have 10 mg of CBD per gummy, adding up to 300 mg in total. Higher potency edibles have 25 mg of CBD per gummy, or 750 mg in one container.

Since the company has built its reputation using only top-notch ingredients, you can be sure Royal CBD gummies are all-natural, without artificial flavorings.

The price for lower-strength edibles is around $60. On the other hand, for a container of higher-dose edibles, we have to pay about $80. As an alternative to gummies, the company offers Sour drops as well.

We Recommend Royal CBD Gummies Because:
  • You can choose between different potencies and flavors
  • Also, you get the premium quality and the best ingredients on the market
  • The company uses supercritical CO2 extraction
  • You can rely on third-party lab testing to check the potency and safety of every product
  • We get 99% pure broad-spectrum CBD, which means gummies don’t contain THC
What We Don’t Like About Royal CBD Gummies:
  • The product is available only on the internet
  • The company has a limited number of products you can buy

2. Gold Bee CBD Edibles — The Runner Up

The next company that produces the best CBD gummies for pain is Gold Bee CBD. Gold Bee is also one of the most popular brands of CBD goods. This company has made a name for itself by offering high-quality products combined with affordable prices. You’ll find mentions of Gold Bee on websites including The Daily World, Herald Net, and more

At Gold Bee CBD, we can find many products, including but not limited to oils, gummies, capsules, and honey sticks. Gold Bee gummies also come in a 30-piece container and various fruity flavors. However, unlike Royal CBD, this company makes edibles in only one potency — 25 mg of CBD per gummy. So, by purchasing one $70 container, you get 750 mg of CBD.

These high-potency treats are infused with broad-spectrum CBD, which means there’s no THC.

Another great thing about Gold Bee CBD is that all of its products, gummies included, are 100% vegan. Everything this company makes is plant-based, without animal derivatives.

In addition, Gold Bee doesn’t use any artificial flavorings. The yummy sweet taste comes solely from sugar cane and fruit juice.

We Recommend Gold Bee CBD Gummies Because:
  • Due to the high dose of CBD, these treats are one of the best CBD gummies for pain
  • They are 100% vegan and natural
  • CBD this company use is high-quality and broad-spectrum
  • It is also extracted using the supercritical CO2 method
  • Gummies don’t contain THC
  • A third-party lab tests every batch for potency and safety
  • Gummies come in different fruity flavors
  • Gold Bee CBD offers a 30-day money-back guarantee for every product you purchase
What We Don’t Like About Gold Bee Gummies:
  • They come in only one potency
  • Sometimes the company can run out of stock due to high demand
  • No single flavor option

3. Blessed CBD

Since the two companies we have mentioned so far don’t sell outside the US, we thought it would be fair to talk about one based in Europe. Blessed CBD is a family-owned company that makes various CBD products. It uses organically-grown hemp imported from Colorado, US.

One of its most sought-after goods is CBD gummies that come in a 30-piece package. But unlike Gold Bee CBD and Royal CBD, this company doesn’t use broad-spectrum CBD. Blessed CBD infuses its edibles with 25 mg of pure CBD isolate.

Furthermore, the gummies are 100% vegan and natural. They come as a mix of four different flavors in one container: lemon-lime, mango, strawberry, and raspberry.

That being said, Blessed CBD also has a reputation of being a bit too pricey. One package of gummies, with a total of 750 mg of CBD, is something over $80. Therefore, some argue that we can find similar products in the UK’s CBD market but for a lower price.

However, we think Blessed CBD produces one of the best CBD gummies for pain because it uses all-natural ingredients. On the other hand, some companies based in the UK use artificial flavoring and preservatives that can cause a negative body response, such as inflammation.

We Recommend Blessed CBD Gummies Because:
  • High potency means better pain relief
  • The company guarantees safety through third-party lab testing
  • Edibles are made of premium quality organically grown hemp
  • CBD isolate is extracted using the supercritical CO2 method
  • They come in four delicious flavors
  • Gummies are completely vegan and natural
What We Don’t Like About Blessed CBD Gummies:
  • You can buy them only in the UK
  • The company uses CBD isolate instead of broad-spectrum CBD, which can lessen the effect
  • The price is a bit too high for the value

4. Tasty Hemp Gummies

Made out of all-natural organic ingredients, Tasty Hemp gummies come in an assortment of three flavors: cherry, lemon, and orange. They provide 25 mg of CBD per gummy and contain organic fruit juices, corn syrup, natural flavorings, and colors. One of the main advantages of choosing this brand is that you can get this dosage at the same price that other companies charge for their 15 mg gummies, making them more affordable than most. While they do test for potency, it appears they do not test for pesticides such as heavy metals and pesticides, so that’s something to consider before buying their brand.

5. CBDfx

Whether you’re a newbie or an experienced user, CBDfx gummies have something that will work. Their gummies come in both 10 mg and 40 mg strengths, and the latter is especially good for severe discomfort or for people weighing more than 200 pounds. They also have products that help with immune support, digestion, and sleep, so you can find more than just products for pain relief. The only disadvantage of their gummies is the fact that they have a lot of sugar in them, but this is likely because they want to mask the taste of the full-spectrum CBD that they put inside of each gummy. Nevertheless, unless you are someone who needs to watch your sugar intake, this shouldn’t make a difference overall.

6. cbdMD

Made out of non-GMO hemp grown in the United States, these gummies come in three different strengths: 10 mg, 25 mg, and 50 mg. They use broad-spectrum CBD extract for the gummies, and the 50 mg gummies are perfect for users who are overweight or suffering from severe pain. The gummies are also available in a mix of orange, tropical, raspberry, and strawberry flavors, and they are both gluten-free and vegan. Best of all, the company lists all of the lab reports on their website, so they are a very transparent company. Some people think their taste isn’t exactly the best, but keep in mind that cbdMD offers a 60-day money-back guarantee if you wish to return anything. This is generous when compared to a lot of other CBD companies.

7. Charlotte’s Web

When the late Charlotte Figi discovered that CBD relieved her of the symptoms of Dravet Syndrome, a childhood-onset epilepsy that is treatment-resistant, CBD was essentially brought into the mainstream. Since then, Charlotte’s Web has enjoyed an impeccable reputation when it comes to producing this product. They make several CBD products, including gummies that go by the name Recovery. These are specifically formulated for pain and contain ginger and turmeric, as well as a whole-plant hemp extract. These gummies not only work on pain but provide anti-inflammatory and antibacterial properties, as well as the ability to boost the immune system. This makes them the perfect way to relieve pain from many different sources.

8. Plus CBD

These full-spectrum CBD gummies contain not just CBD but also the right amounts of terpenes, phytocannabinoids, and flavonoids. They work together to enhance the pain-relieving effect of CBD and also contain ingredients such as seaweed extract, fruit pectin, and organic cane sugar. The gummies are available in both fruit punch and mango, and they come in both 30- and 60-count containers. In the long run, the 60-count container is a little less expensive. Since you get the benefits of full-spectrum CBD in each gummy, they sometimes have a very distinct aftertaste, but the flavors themselves are yummy. If you need pain relief, the Plus CBD gummies are definitely worth trying.

9. Medterra

Medterra offers three types of CBD gummies: Sleep Well, Stay Alert, and Immune Boost, but the latter is also great for pain relief. This gummy contains not only CBD but also vitamin C, elderberry, and zinc, which are known for their anti-inflammatory and anti-oxidative properties. The company itself is based in California and uses locally grown hemp. With Immune Boost, you get 25 mg of CBD in each gummy, which is enough for most people to relieve their pain. If you are overweight or have extreme pain, you can try taking two gummies at a time, but one should be enough for most people. The company offers no discounts on their products and even though they are reasonably priced, they may still be a little higher than other companies.

10. Joy Organics

Joy Organics was formed by Joy Smith, who learned firsthand how good CBD products are in relieving pain. The CBD gummies come in two different flavors – strawberry lemonade and green apple – and they are made with CBD isolate, which means they are made without any other cannabinoids and terpenes in them. They are vegan and contain only natural flavorings and colors, so they are both effective and good for you.

The only drawback is their low dosage – their gummies contain only 10 mg of CBD per gummy. This makes them good for beginners but not so good for people who weigh more than 150 pounds or who need something for extreme pain. These gummies can be cost-prohibitive for those people because they’ll have to take more than one to get the pain relief they need. Still, if you’re taking CBD oil for pain, adding these gummies to your regimen is a good way to help lift your mood without getting “high.”

How CBD Products Help With Pain

Now that we have completed our list of the best CBD gummies for pain, we can move on to see how CBD helps reduce pain.

CBD Lessens Pain Strength

Cannabinoids are great painkillers that occur naturally in the hemp plant, as stated by LA Weekly. CBD works by targeting two different types of pain receptors located in the spinal cord and brain — the vanilloid receptors and opioid receptors. These pain receptors are the ones controlling the strength of pain signals that reach the brain. So, the CBD influences those signals and lessens the volume of pain that goes to the brain.

CBD Lessens Inflammation

Furthermore, some studies have shown that CBD reduces inflammation, which is one of the most common causes of chronic pain. This information is crucial for arthritis patients since the same research has confirmed that CBD can also reduce nerve damage and stop the condition from advancing.

Cannabinoids Have Antifungal and Antibacterial Properties

If we have an open wound that won’t heal, like those caused by diabetes, CBD can do wonders. In such cases, it is best to apply it directly over the wound to fend off an infection and promote healing. However, CBD gummies might also help stop the spread of bacteria and fungi.

Things You Should Know Before Using The Best CBD Gummies For Pain

Gummies are a good option for someone who is a beginner at using CBD products. They are usually milder than oil and more pleasurable to take. If you are taking CBD for the first time, the best would be to start with just a half of a gummy and slowly increase the dose. The point is to find the amount that works and stop there.

By doing so, you can let your body slowly adjust to the effects and watch for any side effects. Also, beginners might start noticing full results after about two weeks of consistent use.

Edibles are very convenient since they are already split into doses, and we can easily take them on the go. However, we should keep in mind that they take a while to start working, usually 30 – 90 minutes. So, in the case of acute pain, edibles might not offer the desired relief. This delay happens because gummies have to go through the digestive system to reach the bloodstream.

Furthermore, there are ways to enhance the effect of CBD gummies. To do so, we can use painkilling supplements such as kava-kava (muscle relaxing herbal supplement), turmeric and boswellia (both have an anti-inflammatory effect), or magnesium (the lack of magnesium can cause chronic pain).

Also, most CBD edibles do not contain cannabis terpenes. However, terpenes have many positive health effects, pain relief included. So, if you want to boost the effectiveness of your gummies, you can try purchasing terpene extracts and consuming them with tasty edibles.

How to Recognize High-quality CBD Edibles

  • Edibles infused with broad-spectrum or full-spectrum CBD are more potent than those infused with CBD isolate
  • High-quality gummies are more expensive because advanced technology is used in the production process
  • The best companies use only natural flavorings and sweeteners
  • Companies that are not open to discussing the production process probably have something to hide
  • Third-party lab testing is important

Final Thoughts

After hemp became legal thanks to the Farm Bill, people have started looking at CBD products as a possible solution for many health problems. There’s no denying that CBD helps with different kinds of pain by affecting pain receptors and reducing inflammation.

Furthermore, the high demand for CBD products has caused various companies to offer products of questionable quality. So, we have to be careful and choose only reputable companies that use high-quality ingredients.

In the end, if we want the best CBD gummies for pain treatment, we should opt for Royal CDB, Gold Bee CBD, or Blessed CBD edibles. These companies use premium quality hemp, natural ingredients, and CO2 extraction methods. Combined with third-party lab testing each company undergoes, these features make for the safest and most trustworthy CBD gummies you can find in 2021.

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Chronic pain can ruin our quality of life. Whether it’s an old sports issue, a work related injury, or sickness or fibromyalgia, pain that keeps coming back or won’t go away can affect everything. Some of us have tried everything, and nothing has worked. And that’s why we’ve turned to CBD products.

CBD, or cannabidiol, is a naturally occurring compound in plants in the cannabis family. Of course it occurs in marajuana, but it’s also in the legal and safe hemp plant. CBD is completely legal, and pure CBD doesn’t contain any THC, the compound that gets you ‘high.’

We’ll review the best five brands we found for pain relief and inflammation. After the reviews, we’ll discuss what the science says about CBD and pain relief.

Best CBD Oils


Best Brand Overall


Most Potent CBD Products

Royal CBD

Best Full-Spectrum Capsules

Cheef Botanicals

Best CBD Edibles

Joy Organics

Best Broad-Spectrum CBD

FAB CBD: Best Brand Overall

When you’re shopping for CBD products, you want reliability and effectiveness. FAB CBD has both. They offer a full range of CBD products, in a variety of potencies, flavors, and sizes.

For pain relief and inflammation, FAB offers a topical cream and a roll on salve. Both are effective, safe, and have tons of customer reviews to back them up. The cream only comes in one strength (600 mg), while the salve comes in two strengths (1000 mg and 3000 mg).

One great part about FAB CBD as a company is their commitment to the product. They didn’t just jump on the CBD hype-train. They are so dedicated to delivering a great product that they make every order of cream and salve to order, meaning you get something made for you, not something that’s been on the shelf for a year-and-a-half.

Also, FAB CBD is fully transparent about all their products. In fact, you can find a link on their website to independent lab reports about their products. We know that trying CBD products for the first time can cause a little doubt or worry, especially going over the internet. Making their lab-reports available to anyone is one of the top reasons we called FAB our Best Brand Overall.

In addition to their transparency, it seems that FAB are just generally good people. They give back to several charities, in a number of ways. In May of 2021 they helped plant over 1,000 trees for Arbor Day, and this year decided to give back some of their Black Friday and Cyber Monday proceeds to a charity called Charlie Rocket’s Dream Machine, a traveling nonprofit that helps others to fulfill their dreams.

Back to their product, itself, we love that you have two options for application, the salve or the cream. The cream itself is like any other body lotion—simply dip your fingers into the cream, and rub it into the sore muscle area or joint. The cream doesn’t leave a greasy film behind, and the scent (blood orange) is only enough to let you know you put something on. It won’t over power your senses.

The salve has a similar consistency to roll-on deodorant, but you use it anywhere on your body that you have an ache or a pain. You can reapply the salve to any area, to get more pain-relief. It’s only scented with essential oils, so there won’t be a heavy smell following you around.

And the salve has another feature we liked: the hot and cold effect that some of the best muscle rubs give. For heating away a tough knot in your muscles, they use Cinnamomum Camphora Oil, while Menthol Crystals comes in for a soothing, cooling sensation.

We liked the whole brand of FAB CBD, but we wouldn’t recommend them here if they didn’t work great, too. Their cream is great for quick, low-grade aches and pains, while the salves are awesome for on-going or recurring sports issues, like for runners, golfers, or even people tapping away on the keyboard for long hours.