cbd oil for high functioning autism

Marijuana and autism: Removing the stigma

Jeremy, 47, is a political writer in Washington, DC who spends his spare time writing screenplays and producing what he calls “nerd punk rap” music. Jeremy also has autism and has suffered from lifelong side effects including crippling anxiety, social avoidance, and physical pain. But he has found a unique – and natural – way to treat his autism: marijuana.

Using Cannabis for Autism Symptom Relief

“Especially for those in the Asperger’s range, anxiety can be crippling,” Jeremy says. “It’s why autistic kids act out and can become loud and violent; they’re usually dealing with an anxiety they can’t control.”

For Jeremy, using marijuana for autism has been surprisingly effective: the drug helps relieve these debilitating emotional issues while also easing secondary physical symptoms that were harming his body and causing chronic pain.

“My anxiety causes a lot of clinching and holding muscles in stressful and eventually painful ways,” he says. “Marijuana reduces both the clinching and the resultant pain.”

Alleviating his physical and emotional pain allows Jeremy to live and work more fully. As a high-functioning professional, using medical marijuana for autism is highly practical: smoke until the symptoms reduce enough to allow him to go ahead with what he was planning to do.

With his successful writing career and multiple side gigs, Jeremy could not be more different from the stereotype of the zoned-out “stoner.”

“The great thing about marijuana,” he adds, “is that you can tell how much to smoke because the effects are quick and obvious. If I’m in pain, the pain lessens. If I have anxiety, it goes away.”

Marijuana’s ability to reduce pain and anxiety allows Jeremy to be more productive in his daily life; it also allows him to stop perseverating on negative thought patterns. “Marijuana is powerful because it restarts various synapses that stop firing,” he says. “This is super powerful for autism because part of the problem is that you get stuck in patterns and routines, because your brain stops seeing the other pathways.”

With his successful writing career and multiple side gigs, Jeremy could not be more different from the stereotype of the zoned-out “stoner.” But can marijuana treatment work for others with autism too?

As More Children are Diagnosed, Families Want More Treatment Options

Autism Spectrum Disorder (ASD) is a cognitive and developmental disorder that covers a range of neurological symptoms from mild to severe. According to the Centers for Disease Control, about one in 59 children in the U.S. has ASD, and the prevalence has risen biannually since 2002.

Since autistic behaviors frequently include rejection of physical and eye contact, a lack of facial expression, and a perceived disinterest in communication – all of which makes it harder to connect with others – autism can lead to social isolation. As there is no “cure,” treatments include behavioral, speech, and coping therapy, together with medication to help control symptoms like depression and inability to focus. However, these treatments do not work for everyone and often result in unwanted side effects.

Using medical marijuana for autism is highly practical: smoke until the symptoms reduce enough to allow the individul to go ahead with what they were planning to do.

With a dearth of effective treatments, there has been a recent push by parents to expand the use of medical marijuana to treat their children’s autism. In 2014, a group of mothers came together to form Mothers Advocating Medical Marijuana for Autism (MAMMA) to advocate for legalized access. The group’s goal is for marijuana to become a legally sanctioned treatment for people with autism nationwide.

AmyLou Fawell, the organization’s co-founder and president, has been advocating for change in her home state of Texas. Fawell, a devout Christian and longtime Republican, has helped add credibility to the marijuana for autism movement in a state known for being conservative. In fact, her organization began at a Bible study for mothers of special-needs kids. After the group viewed CNN medical correspondent Dr. Sanjay Gupta’s pivotal documentary, Weed, it realized that marijuana could help alleviate the symptoms of developmental disorders like autism.

“About half of our (autistic) kids will have self-injurious behaviors, aggressive behaviors, or both,” Fawell says. This includes Fawell’s adult son, Jack, who bites his hands when he is frustrated. Citing a 2006 study where Marinol, a synthetic form of THC, was used to treat children with self-injurious behavior Fawell says, “It significantly reduced the amount of self-injury that (the children) exhibited.”

Israeli Researchers Find a Promising Connection Between Marijuana and Autism

While research on cannabis and autism is still in its early stages, a number of new studies are now in trial. Israel (which legalized medical marijuana in 1992) is leading the way in researching marijuana’s effectiveness in reducing both seizures and behavioral challenges.

In 2019, Israel’s Ben Gurion University of the Negev released a study that shows a promising connection between marijuana and autism. The study followed 188 children with autism, aged 18 and under, for six months as they used cannabis oil for autism symptoms. The oil contained 30% cannabidiol oil (CBD) and 1.5% tetrahydrocannabinol (THC). According to the study, after six months of treatment more than 80% of participants reported “significant or moderate improvement.”

Patients experienced various cognitive improvements. Before the trial, only 3% of patients reported being able to get a good night’s sleep; during treatment, that number climbed to 25%. Concentration also dramatically improved, jumping from zero to 14% of patients being able to concentrate with treatment.

Behavioral side effects of autism, including seizures, restlessness, and rage attacks, were also significantly improved by the marijuana treatment. Nearly 85% of patients had their seizures completely disappear, 91% noticed an improvement in restlessness, and 90% reported a reduction in rage attacks.

Importantly, the study found that marijuana also improved the ability to complete daily tasks. Prior to the study, for example, only 26% of patients were able to dress and shower themselves without help. After treatment, that number jumped to 43%.

When it Comes to Marijuana and Autism, More Access Is Needed

For Jeremy, living with autism is no longer debilitating – but only because he can moderate the negative effects with marijuana. “If your (autism) symptoms don’t overwhelm your brain,” he explains, “you can have the ability to focus on things and process information at a higher level than other people.” This allows him to be extremely productive, both at work and in his side interests. He also notes that, for him, “the interaction of marijuana and autism seems to preclude some of the negative effects others have with marijuana – such as paranoia and hunger.”

For Jeremy, living with autism is no longer debilitating – but only because he can moderate the negative effects with marijuana.

Thanks to the 2014 passage of Initiative 71, which legalized marijuana use in Washington, DC, it’s easy for Jeremy to obtain the treatment he needs, and he feels there is no stigma attached to discussing his treatment with his doctor and friends. But Jeremy – and his access to cannabis for autism – is an exception.

Currently, recreational marijuana is only legal in 11 states and, while medicinal use is available in 33 states, there are still many restrictions that can make it difficult to obtain. Meanwhile, most of the global research on marijuana and autism has focused on children – and practically no work has been done on the effects of marijuana on the millions of adults like Jeremy who live with autism.

That means that AmyLou Fawell will continue to lobby for marijuana access for her adult son in Texas. “With almost 1.5% of the population being diagnosed with autism, that’s a lot of Texans with autism,” she points out. “There is a great need for cannabis to help us.”

CBD & Autism:
Can it help? February 2022

Recent studies of CBD-rich cannabis extracts in autistic children show promising findings. While it’s not a cure, CBD may improve some symptoms of this difficult-to-treat condition.

Evidence Based
17 references

Checked for Accuracy

Ana Luiza Dias, Ph.D.

Strength of
Evidence

CBD may significantly improve some symptoms of autism.

CBD may improve some symptoms of autism and related issues such as anxiety and sleeping problems. However, it has to come in the form of a whole-plant cannabis extract.

CBD may improve some symptoms of autism and related issues such as anxiety and sleeping problems. However, it has to come in the form of a whole-plant cannabis extract.

Cannabidiol (CBD) is a popular option for dealing with pain, insomnia, and other common health problems. This non-intoxicating cannabinoid may also hold some benefits for autism spectrum disorder.

Recent human studies of CBD-rich cannabis extracts found significant improvements in symptoms of autism and related issues, such as anxiety and sleep disturbances.

Read on to learn more about using CBD for autism, how it works, the research evidence, side effects, dosage, and more.

Autism Overview

Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects communication and behavior. It causes difficulties in socializing and communicating alongside restricted interests and repetitive behaviors.

Autism spectrum disorder typically begins at an early age and continues into adulthood, causing difficulties at school, work, and other social situations.

It includes several conditions that were considered separate in the past, such as autism and Asperger’s syndrome. Since it’s a spectrum disorder, the severity can vary from person to person.

That means some children with ASD have low intelligence and significant difficulties with learning, whereas others might have normal or high intelligence but still have trouble with communicating and socializing.

ASD is estimated to affect about 0.76% of people worldwide and 1 in 59 children in the United States. ¹ Boys are about three times as likely as girls to be diagnosed with ASD.

Although there’s no single cause of autism, researchers believe the interplay of genetic and environmental factors affecting the developing brain plays a major role.

For example, studies have found structural differences in some parts of the brain of children with ASD. Researchers are also continuing to identify genes associated with ASD.

Meanwhile, environmental risk factors include advanced parental age, prenatal exposure to air pollution or pesticides, and maternal immune infections or disorders.

Autism Subtypes

Before it was reclassified into a spectrum disorder in 2013, autism was divided into four related conditions: ²

  1. Asperger’s Syndrome: A milder, high-functioning form of autism. People with Asperger’s have normal to high intelligence and can handle adult life. However, they still struggle socially and may have limited interests.
  2. Pervasive developmental disorder not otherwise specified (PDD-NOS): A term for autism that’s more serious than Asperger’s but not as severe as autistic disorder.
  3. Autistic disorder: This disorder has the same types of symptoms as other forms of autism but is more severe.
  4. Childhood disintegrative disorder: The rarest and most severe type of autism, this disorder causes children to have severe and sudden reversals in language, social, and motor skills.

Autism Symptoms & Pathology

The symptoms of autism spectrum disorder (ASD) include, but aren’t limited to:

  • Limited social interaction with peers
  • Poor eye contact and lack of facial expressions
  • Delayed speech and difficulty communicating
  • Repetitive movements or phrases
  • Difficulty reading body language
  • Clumsiness
  • Following specific routines and having obsessive interests
  • Sensory sensitivity
  • Intensely focusing on an object or activity

Some children with ASD may have intellectual disability and difficulty learning, whereas others can have normal or high intelligence. ASD is also associated with a higher risk of seizures, gastrointestinal issues, and anxiety disorders.

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Can CBD Help With Autism?

CBD may help ease the symptoms of autism spectrum disorder.

It mainly works by interacting with the body’s endocannabinoid system (ECS), which regulates vital physiological and cognitive processes, including learning, mood, sleep, and inflammation. ³

This system is made up of endocannabinoids naturally made by our bodies, the cannabinoid receptors they activate, and enzymes that build and break them down. A growing volume of research suggests that ECS dysfunction is involved in autism. ³

For example, one 2018 study found that children with ASD had lower levels of the endocannabinoid anandamide than their healthy counterparts. ⁴

Similarly, a 2019 study reported lower levels of three endocannabinoid molecules — anandamide, OEA (oleic acid), and PEA (palmitoylethanolamide) — in ASD children. ⁵

Another 2021 study found that autistic children and mice had reduced levels of endocannabinoids, and higher levels of endocannabinoid-degrading enzymes and cannabinoid receptors. ⁶

The researchers concluded that “Current evidence strongly implicates alterations in the eCB system in human patients with ASD and in animal models.” ⁶

Indeed, the ECS regulates major processes involved in ASD, including brain development and the function of neurons and other brain cells. ⁷ It also influences other issues commonly seen in ASD, such as seizures, anxiety, and sleep disturbances.

That’s why targeting the ECS with cannabinoid-based treatments is a growing area of research.

CBD in particular has a lot of promise because it’s been shown to increase the levels of anandamide, one of the two major endocannabinoids, and lacks the intoxicating effects of THC. ⁸

CBD has also been shown to have anxiolytic (anxiety-reducing), antidepressant, antipsychotic, and other beneficial cognitive effects by acting on serotonin receptors and other systems. ⁹

As a result, it may help with anxiety, seizures, and other issues that commonly occur alongside autism spectrum disorder.

What Does the Research Say?

Research on the use of CBD for autism is steadily growing.

Israeli researchers published the most noteworthy study in 2021, which compared the effects of CBD-enriched cannabis oil (with a 20:1 ratio of CBD to THC) and pure CBD/THC oil to placebo. ¹⁰

A total of 150 children with ASD were assigned to one of the three treatments for 12 weeks before taking a 4-week break and changing groups for another 12 weeks. ¹⁰

Pure cannabinoids had no significant effect. However, 49% of the children taking whole-plant extract saw improvements in disruptive behavior versus 21% for placebo. The whole-plant extract also improved scores on the SRS scale of ASD severity by 14.9 points versus only 3.6 for placebo. ¹⁰

In a similar 2018 study, 60 children with ASD took CBD-enriched cannabis oil (with a CBD/THC ratio ranging from 20:1 to 6:1) daily for 7-13 months. ¹¹

Seven children withdrew due to side effects and low efficacy. However, 61% of those who completed the study saw significant improvements in behavioral outbreaks. Many also reduced or stopped their use of other medications. ¹¹

Meanwhile, a 2019 study looked at the effects of CBD oil with a 20:1 ratio of CBD to THC in 53 ASD children and adults (aged 4-22). They took the oil for anywhere from 30 to 588 days. ¹²

Self-injury and rage attacks improved in 67.6%, hyperactivity symptoms in 68.4%, sleep in 71.4%, and anxiety in 47.1%, although a small number of children had the opposite, negative effect. ¹²

Another 2019 study looked at the effects of CBD-enriched cannabis extract with a 75:1 ratio of CBD and THC in 18 children with autism. They took capsules daily for 6-9 months. ¹³

Three children discontinued the treatment after a month due to side effects and one didn’t see any changes. ¹³

However, the remaining 14 children saw improvements in more than one of eight symptom categories: attention-deficit hyperactivity disorder (ADHD), behavioral disorders, motor deficits, autonomy deficits, communication and social interaction deficits, cognitive deficits, sleep disorders, and seizures. ¹³

There were particularly big improvements in symptoms of seizures, ADHD, sleep disorders, and communication and social interaction deficits. ¹³

The researchers concluded that “…CBD-enriched CE yields positive effects in multiple autistic symptoms, without causing the typical side effects found in medicated ASD patients.” ¹³

Overall, the findings are promising and suggest that whole-plant, CBD-rich cannabis preparations may help with many symptoms of autism and related issues. However, further placebo-controlled studies are required.

Using CBD for Autism

According to the research, whole-plant, CBD-rich cannabis extracts work best for autism.

This provides further evidence for the entourage effect: the fact that cannabis works best when all of the cannabinoids, terpenes, and other phytochemicals are used together instead of isolated THC and CBD.

As such, full-spectrum CBD products are the ideal choice for autism since they contain the same active compounds and a similar, high ratio of CBD to THC. ¹⁴

In particular, we recommend using full-spectrum CBD oil because the most rigorous studies also used whole-plant, sublingual (under-the-tongue) cannabis oil.

Although full-spectrum CBD capsules can also help, they will have weaker effects because CBD and other cannabinoids have low oral bioavailability. ¹⁵

How Much CBD Should I Take for Autism?

The right dosage of CBD for autism will be different for everyone. It varies depending on body weight, genetics, symptom severity, product type, and other factors.

It’s best to start with a low dose and slowly raise it over time. ¹⁶ You could begin with 10-15 mg of full-spectrum CBD and wait for about two hours to see the effects.

If it’s not enough, gradually increase the dosage over time, making sure to stop for at least two hours to assess how you or your child feel. Use this conservative approach to find the right CBD amount for your desired effects.

Older children have seen improvements at 25mg of CBD twice a day. Some adults have even taken as much as 90mg of CBD split over three times a day.

Are There Any Side Effects?

Studies of CBD-rich cannabis extracts reported mostly mild side effects, such as sleepiness, decreased appetite, sleep disturbances, irritability, euphoria, and anxiety. ¹⁷

However, it should be noted that these effects are not just from CBD but also other cannabinoids and terpenes present in whole-plant extracts. ¹⁷

For example, the mild euphoria and anxiety reported by one study were likely due to the small amounts of THC, the main intoxicating component of cannabis. ¹⁷

Aside from that, research has shown that pure CBD is a relatively safe substance with few and minor side effects. ¹⁷

Conclusion

Clinical studies of CBD-rich cannabis extracts in children with autism spectrum disorder are promising.

Although further research is needed, CBD may help improve many of the symptoms of autism and might also help with related issues such as seizures, anxiety, and sleeping problems.

In most cases, the researchers used whole-plant cannabis oil rich in CBD and low in THC. That’s why it’s recommended to use full-spectrum CBD oil, which is the closest equivalent. You can start with a low dose and slowly increase it over time.

CBD is a safe compound and the extracts used in research resulted in mostly minor side effects.

Sources (17)
Gleb Oleinik

Gleb Oleinik is a freelance CBD & cannabis writer from Vancouver, Canada. He’s read thousands of studies about cannabinoids and other beneficial natural compounds, helping him translate complex science into plain language. He’s also written third-party lab test reports of CBD products and knows the industry inside and out. When he’s not writing, Gleb likes to spend his time in the gym and out in nature.

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