Best CBD Oil for Cerebral Palsy – February 2022
Cerebral palsy (CP) is a congenital condition affecting movements, muscle tone, and body posture. This lifelong condition is diagnosed during infancy or early childhood.
The primary cause of CP is a brain injury or malformation during neonatal development (12) .
Symptoms of cerebral palsy include muscle contractions , spasticity, lack of muscle coordination and balance, involuntary movements, speech delay, learning difficulties, lack of motor skills, and tremors .
The types of cerebral palsy depends on the symptoms presented by the individual.
Spastic cerebral palsy presents with spasms. Axatic cerebral palsy causes trouble with muscle coordination and balance. Dyskinetic cerebral palsy causes involuntary movements.
CP treatment options include surgical procedures, physiotherapy, botox injections, or oral muscle relaxants, such as diazepam, dantrolene , and baclofen (13) .
However, muscle relaxants have several side effects , including lightheadedness, lack of muscle control (ataxia), blurred vision, and depression (14) .
Moreover, individuals taking muscle relaxants are also at risk of dependency and withdrawal symptoms (15) .
Meanwhile, CBD has potential health benefits that may be useful for people with CP.
CBD vs Spasticity
Currently, there is only one direct study on cannabidiol’s ( CBD ) therapeutic effects on cerebral palsy symptoms .
The Wolfson Medical Center conducted a clinical trial using CBD and THC (with ratios 20 to 1 and 6 to 1) on children with cerebral palsy (CP) .
The study, led by child neurologist , Dr. Luba Blumkin , found that the CBD treatment significantly reduced dystonia , spasticity , sleep difficulties, and pain among CP patients (16) .
The clinical trial’s result was supported by other studies on CBD ’s efficacy in treating motor disorders .
A 2018 study posted in Neurological Disorders mentioned that CBD , with the combination of THC , reduced spasticity in human subjects (17) . The authors attributed this hypothesis to CBD ’s neuroprotective, anti-inflammatory, and muscle relaxant properties (18) .
CP and multiple sclerosis have often been studied together due to similarities in muscle spasms and stiffness symptoms exhibited by the conditions (19) . Researchers mention that both conditions cause upper neuron motor dysfunction (20) .
A 2015 review indicated that the first-line treatment for both conditions involved muscle relaxant and anti-convulsant agents (21) .
However, the authors noted that young children and the elderly displayed adverse effects from the treatments (22) .
A study posted by Frontiers in Neurology has noted that CBD treatments improved mobility and reduced spasticity among multiple sclerosis patients. Moreover, CBD ’s efficacy significantly reduced the usage of prescription medicines (23) .
CBD vs. Cerebral Palsy-Associated Conditions
CBD might also potentially treat other conditions associated with CP.
Studies mention that 23-46% of children with CP experience sleep disturbances. These are usually caused by the child’s immobility and pain (24) .
Due to inactivity, adults with CP have higher risks of anxiety, depression (25) , cardiovascular disorders, and rheumatoid arthritis (26) .
Lastly, studies have shown that children with CP have a high risk of developing seizure disorders. The authors indicated that spastic tetraplegia, a form of cerebral palsy , might be associated with seizures (27) .
A study found that CBD reduced depression in human subjects (28) . Moreover, studies found that CBD has therapeutic potential in treating high blood pressure (29) and arthritis (30) .
A study posted by the Permanente Journal also demonstrated CBD ’s efficacy in reducing anxiety scores and improving insomnia among human subjects. The authors observed that among the 72 adults who participated, 79.2% had reduced anxiety, while 66.7% improved their sleep scores (31) .
Lastly, researchers confirmed CBD ’s efficacy in treating epileptic seizures, especially in pediatric age (32) . The epileptic drug, Epidiolex, is the first FDA-approved CBD drug used to treat rare forms of epilepsy (33) .
How CBD Oil Works to Help With Cerebral Palsy
The endocannabinoid system (ECS) is studied for its role in maintaining homeostasis in the human body. Studies have acknowledged that activation of cannabinoid receptors, CB1 and CB2, plays a role in modulating functions in the central nervous system (34) .
Researchers indicated the high density of cannabinoid receptors in the cerebellum and basal ganglia (areas that control motor function ) (35) .
Studies showed that CB1 expression plays a role in motor function and spasticity among patients with neurodegenerative disorders (36) .
A study released by Therapeutic Advances in Neurological Disorders has shown that CB1 receptors in the CNS pathways are targets that can deliver antispastic effects. The author added that treatments using cannabinoids might potentially stimulate these targets (37) .
Moreover, CB2 expression has been observed to block inflammatory cytokin es (proteins released by cells) in the ce ntral nervous system (CNS). Studies explained that inflammation in the CNS might be the cause of various symptoms, such as tremors and spasms (38) .
Still, more studies are needed to learn how cannabinoids might influence the ECS and CNS of cerebral palsy patients .
The Pros and Cons of CBD Oil for Cerebral Palsy
- CBD treatments significantly reduced cerebral palsy symptoms , such as dystonia , spasticity , sleep difficulties, and pain (39) .
- CBD ’s efficacy in reducing spasms led to decreased usage of muscle relaxant and anti-convulsant agents (40) .
- CBD might reduce anxiety, insomnia (41) , and depression in adults with CP (42) .
- CBD has therapeutic potentials in lowering blood pressure (43) and alleviating joint pain (44) .
- CBD’s efficacy in treating seizures has been proven by studies (45) .
- CBD has been acknowledged to have an excellent safety profile for human consumption (46) .
- CBD may cause side effects , such as drowsiness, loss of appetite, and dry mouth (47) .
- A recent study discovered that high CBD dosage caused hepatotoxicity (liver damage) in rat models (48) .
- CBD is not an approved treatment for CP, and further studies are needed to determine any possible benefits.
How CBD Oil Compares to Alternative Treatments for Cerebral Palsy
The echinacea plant has been traditionally used as an alternative or complementary medicine for CP (49) .
Some of the herb’s medicinal claims include improved blood circulation, neural connections, and reduced spasticity . However, until studies prove otherwise, echinacea’s clinical value remains to be seen.
B12 and omega-3 fatty acid vitamins have been recognized to improve cognitive function. A 2017 study mentioned that early intervention using B12 and omega 3 supplements might improve cognitive functions (50) .
CT scans demonstrated this hypothesis following B12 and omega-3 treatments. Children who have hypertonia (muscle stiffness), brain atrophy, and delayed milestones and speech displayed improvements in neuroimaging results (51) .
Zingiber officinale (ginger) had been studied for its potential to improve brain functions. A study indicated that ginger root extracts enhanced both attentive and cognitive processing in human subjects (52) .
Although CBD has not been shown to improve children’s learning capabilities, it has been acknowledged for its neuroprotective properties (53) .
A study posted by the British Journal of Clinical Pharmacology indicated that CBD reduced hypoxia-ischemia (brain damage) and improved brain function in animal models (54) .
Moreover, CBD has been observed to possess muscle relaxant properties that might be useful in alleviating hypertonia (55) .
How to Choose the Best CBD Oil for Cerebral Palsy
The recommended CBD oil for individuals with CP is the full-spectrum option.
Full-spectrum CBD oil contains all the major cannabinoids in hemp, such as CBD , cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN), and tetrahydrocannabinol ( THC ).
Together, these compounds create a cannabinoid synergy known as the “entourage effect.”
A review published in Frontiers in Plant Science indicated that the entourage effect increased the activity of ECS receptors (56) .
The author also explained how CBD, combined with other cannabinoids, displayed high efficacy compared to isolated compounds (57) .
Another study demonstrated the entourage effect through a controlled trial on patients with chronic pain (58) .
The authors found that THC treatment failed to reduce pain scores significantly. However, treatments containing THC and CBD showed better results (59) .
Individuals who want to experience the entourage effect without THC may opt for broad-spectrum CBD . Broad-spectrum contains all the same compounds from full-spectrum except THC .
Cannabis products, such as medical marijuana and cannabis oil , are high in THC . Depending on the dispensary , some cannabis products may contain 28% THC (60) .
In the United States, CBD products are prohibited from carrying more than 0.3% THC (61) .
Individuals who want to take CBD as monotherapy may opt for CBD isolates (99% pure CBD ).
Additional tips to consider before buying CBD :
- Look for the product’s certificate of analysis (COA) to determine cannabinoid content and safety profile.
- Do thorough research and check testimonials and reviews of CBD brands.
- Send inquiries to the customer service department for more information.
CBD Dosage for Cerebral Palsy
More studies are needed to find the appropriate CBD dosage for CP symptoms. However, for any medical condition, e xperts recommend that first-time CBD users start with a low dose and gradually increase when the body gets used to CBD .
A study posted by the British Journal of Clinical Pharmacology collected thousands of clinical CBD dosing data on various health conditions (62) .
The authors indicated that appropriate dosing might range from 1 to 50 milligrams per kilogram a day (63) .
Moreover, Pharmacology and Pharmacy shared a study explaining that CBD has a bell-shaped dose-response. The authors observed that a limited CBD dose was enough to produce significant results (64) .
A study from Frontiers of Pharmacology supported the bell-shaped dose-response. The authors observed that the 300mg dose reduced anxiety scores better than 150mg and 600mg dosings (65) .
However, individuals with CP must practice caution when experimenting with CBD dosage.
A study released by Molecules found that extremely high CBD doses can cause liver damage in rat models (66) .
How to Take CBD Oil for Cerebral Palsy
The most straightforward administration for individuals with CP is through oral or sublingual delivery.
Oral CBD products include capsules, softgels, and gummies. Individuals may take oral CBD with or without a meal.
Sublingual delivery methods are available through CBD tinctures. CBD may be taken by using an applicator to put a few drops under the tongue.
Studies have shown that sublingual and oral administration allows plasma concentration to last three to four hours after intake (67) .
Moreover, taking CBD through oral and sublingual administration was observed to provide high plasma concentrations when taken with a meal. However, CBD intake during an empty stomach produced faster results (68) . However, consuming CBD on a full stomach actually provides maximal absorption.
CBD smoke or vapor inhalation is another way of taking CBD. While it is not recommended for children with CP, it may be an option for adults who have the approval of their licensed physicians.
The lungs are very efficient in absorbing CBD into the body. There is evidence that vaping or smoking delivered plasma concentrations into the bloodstream in less than 10 minutes (69) .
Vaping or smoking CBD may be useful for quick relief from pain, severe spasms, or tremors . However, vaping may present some side effects , such as shortness of breath, chest pain, chemical irritation, and allergic reactions (70) .
Cerebral palsy is a lifelong condition. Recommended treatments, alternative, and complementary medicine are only utilized to improve the quality of life .
Studies have shown that CBD significantly reduced cerebral palsy symptoms , such as dystonia , spastic movements , sleep difficulties, and pain (71) .
CBD ’s efficacy in reducing spasms led to a decreased use of muscle relaxant and anti-convulsant agents (72) .
Moreover, studies have shown that CBD might be useful in treating medical conditions that may arise concurrently with CP, such as high blood pressure (73) , arthritis (74) , and seizures (75) .
Researchers have shown that CBD might improve mental health due to its sleep-promoting, anxiolytic (76) , and antidepressant properties (77) .
Whatever medication is being used, individuals with CP must take the necessary measures to improve mobility and function. Participating in physical therapy, rehabilitation (78) , and speech therapy (79) may positively impact their quality of life.
Individuals with CP must consult with a licensed physician before taking CBD into their daily regimen.
CBD Oil in Leesburg: Why This Healthcare Trend Is So Popular
Even so, there’s still a lot of misunderstanding about CBD oil and its uses. For example, a lot of people wonder if using this oil will make them high. They wonder if there are any side effects or if the benefits are too good to be true.
Today, you’ll learn how this compound affects the body’s endocannabinoid system and why you should try it.
What Is the Endocannabinoid System and How Does CBD Oil Impact It?
The endocannabinoid system is composed of endocannabinoids (neurotransmitters that bind to cannabinoid receptors). It is also composed of cannabinoid receptor proteins, which are located in both the peripheral and vertebrate central nervous system. In other words, they’re located in the nerves of the head and spine, as well as those outside the brain and spinal cord.
Cannabinoid receptors help to regulate pain and inflammation.
How CBD Oil Can Help You Feel and Function Better
Inflammation can be caused by disease, trauma, and stress. If not addressed and reduced (or eliminated), inflammation can lead to chronic pain , as well as other diseases .
CBD oil is phytocannabinoid cannabidiol, a natural cannabinoid found in the cannabis plant. It is a concentrated oil found in the naturally occurring resin that coats the plant and its leaves.
CBD is related to THC (tetrahydrocannabinol), the active ingredient in marijuana that gets users high. Though related, CBD does not provide the same mind-altering effects of THC.
So, why are CBD products so popular ? It’s because the chemicals in CBD oil can help relieve pain, anxiety, depression, and cancer-related symptoms. CBD oil has also proven effective in improving heart health and symptoms of neurological diseases like Parkinson’s, and possibly even preventing tumor growth and diabetes.
Your Leesburg Chiropractor – Treating Sports Injuries and More with CBD
Dr. David Wren encourages his patients to stay active for better health. So much so, that he’s actively involved in the Special Olympics. Dr. Wren knows that athletes and non-athletes alike can experience painful conditions that make it hard to stay active. That’s why he is a distributor of TrueMED CBD oil products . These high-quality products will ease your pain so you can live a happy, fun, active life.
Curious if CBD oil might benefit you? Contact our team at 229-883-0042 to schedule a consultation.