Cannabis Science Develops Inhalation Medication for Those Suffering Asthma/COPD via Nebulizer, Targets National Markets
July 29, 2016 14:22 ET | Source: Cannabis Science, Inc. Cannabis Science, Inc.
Encino, California, UNITED STATES
IRVINE, CA–(Marketwired – Jul 29, 2016) – Cannabis Science, Inc. ( OTC PINK : CBIS ), a U.S. company specializing in the development of cannabis-based medicines, is pleased to announce they will release an inhalation medication for those suffering asthma/COPD for use in patient nebulizers. This product will be offered in states where marijuana is legal on a national basis.
Based on State by State laws the Company can proceed with studies in the 25+ states approved for medical marijuana, and lay the groundwork for expanding into other states across the nation as legislation changes and more states become legal. This could also be seen as a mechanism to verify the effectiveness of CBD/THC on patients that use the medication as a bronchodilator.
Studies have shown CBD/THC to be effective as a bronchial dilator and in many cases being better that Albuterol or Ipratropium.
Studies have demonstrated that THC may act as a temporary (1-2 hours) bronchodilator, especially when ingested. The New England Journal of Medicine, published a 1973 study that stated, “Marihuana smoke, unlike cigarette smoke, causes broncho-dilation rather than broncho-constriction [narrowing of the air passages] and, unlike opiates, does not cause central respiratory depression [i.e. a decrease in breathing].”
Another long-term study (20 years) done from 1985 to 2006, examined 5,000 subjects from three American cities. The researchers questioned the participants about their cannabis and cigarette use, and tested lung capacity as well as rate of air flow out of their lungs. To their surprise, the researchers found that at low to moderate levels of cannabis smoking, lung volume and air flow rates both increased with each “joint year” (365 joints), up until seven joint-years (or 2,555 joints).
Bronchodilatory effects – Studies performed in the 1970’s at the University of California Los Angeles by Donald Tashkin have shown that both inhaled and orally ingested THC produce bronchodilation for up to two hours after administration  . Further investigations by the Respiratory Pharmacology Laboratory in Paris have shown that CB1 receptor activation inhibits cholinergic contraction in a concentration-dependent fashion, offering a possible mechanism for acute bronchodilation associated with cannabis intake  . Although smoked cannabis also has this effect, any kind of combustion creates other lung irritants that would be counterproductive for COPD treatment.
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that makes it difficult to breathe. “Progressive” means that the disease gets worse over time.
Approximately 12 million people in the United States have been diagnosed with COPD. Many more may be affected and not know they have it.
CHRONIC OBSTRUCTIVE PUMONARY DISEASE (COPD) LUNG FUNCTION & CANNABIS STUDIES COMPLETED
Marijuana has long been reported to relieve symptoms of asthma. Now, research explains why marijuana’s main ingredient may help patients breathe easier.
How Cannabinoids may help COPD
- Cannabinoids relieve inflammation
- Cannabinoids are anti-microbial
- Cannabinoids support / modulate the immune system and its response to infection and disease
- Cannabinoids are expectorants
- Cannabinoids are analgesic (pain relief)
- Cannabinoid medicine has little to no side effects
In COPD, air flow is restrictive due to:
- The airways + air sacs have a lack of elasticity
- Air sac destruction and inflammation
- Increased mucus and clogged airways
Published last week in the British Journal of Pharmacology, a new study shows marijuana may have a similar effect on the airways as some asthma medications.
Using samples of human lung tissue, French researchers found that THC could block muscle contractions caused by a signaling molecule called acetylcholine.
Acetylcholine is responsible for maintaining muscle tone of the airways and also contributes to contractions in asthma attacks. Interestingly, asthma medications block the same molecule, but from a slightly different angle.
“They prevent the acetylcholine from binding to its receptor,” explains Dr. Donald Tashkin, who was not involved with the study. “But THC works proximal to that. It doesn’t have any competitive effect for binding to receptors. It just prevents the acetylcholine from being released.”
Dr. Donald Tashkin, a lung expert and professor of medicine at UCLA, was part of the team that first discovered marijuana’s effect as a bronchodilator. In 1973, his group published a study in the New England Journal of Medicine that found airways widen in both healthy and asthmatic individuals after smoking marijuana.
“It also succeeded in reversing experimentally induced asthma, in a manner that was comparable to what could be achieved with a standard therapeutic bronchodilator that was widely used at the time.”
Dr. Tashkin explains, “I don’t know if anyone’s ever studied the effect of vaporized THC on airway smooth muscle, but my guess is that it would lead to bronchodilation.”
About Cannabis Science, Inc.
Cannabis Science, Inc., takes advantage of a unique understanding of biologic processes to provide novel treatment approaches for common ailments and for those disorders where current treatments are relatively unsuccessful and understanding remain incomplete. Cannabinoids have an extensive history dating back thousands of years, and currently, there are a growing number of peer-reviewed scientific publications that document the increasingly complex underlying biochemical pathways that cannabinoids modulate. The Company works with leading experts in drug development, medicinal characterization, and clinical research to develop, produce, and commercialize novel therapeutic approaches for the treatment for illnesses caused by infections as well as for age-related illness. Our initial focus is on skin cancers, HIV/AIDS, and neurological conditions. The Company is proceeding with the research and development of its proprietary drugs as a part of this initial focus: CS-S/BCC-1, CS-TATI-1, and CS-NEURO-1, respectively.
Can You Put CBD Oil in a Nebulizer?
A nebulizer is a popular device to deliver medicine into the lungs by breaking up molecules into tiny aerosol droplets. You inhale this mist and medicine immediately gets absorbed by the lungs. Because nebulization expedites the arrival of onset of action, it shows great efficiency in treating lung issues. But what if we want to use a nebulizer with a CBD oil to treat not only respiratory diseases but also alleviate pain, minimize anxiety, and support cardiovascular function? In theory, nebulizer and CBD oil benefits combine can become a lifesaver for people seeking an ultrafast and effective way to improve their symptoms.
CBD oil is already used in vaping – you load it into a vape pen, it heats the solution, and you inhale vapors. Except for heating, it sounds pretty similar to what a nebulizer does. But can you put CBD oil in a nebulize r and expect it to work the way you envision? Unfortunately, things are a little more complicated than they seem at first glance.
CBD Oil and Nebulizers – Friends or Foes?
Nebulizers diffuse water-soluble preparations. CBD oil is, well, oil! Oils are hydrophobic meaning that they don’t blend with water. Even if you add a few drops of CBD oil into the water and try to diffuse this, you won’t be able to break up oil molecules into small particles to inhale. Chances are that CBD oil will simply settle on your skin, hair, and clothing. Besides this, oils are viscous and sticky, which means that they can easily damage a nebulizer’s compressor or clog a hose.
CBD oil is commonly available as tinctures and alcohol-based preparations. Alcohol dissolves in water, so it shouldn’t be a problem to diffuse it, right? Well — not exactly. Surely, a tincture can be nebulized but small alcohol droplets will surely irritate the mucous membrane of the eyes, nose, and throat. Try to spray some perfume around and breathe it in and you will understand how nebulizing CBD oil tincture feels like.
Does it mean that there is no way to administer CBD through inhaling diffused droplets? Don’t fear — there is a way! The bright minds of the pharmaceutical industry have come up with a way to emulsify CBD oil using a technology called nanoencapsulation. CBD emulsion is loaded into a jet nebulizer and compressed air sprays it like a mist.
To make a long story short, CBD oil is a no-go for nebulizers because it can’t be effectively diffused. If you want to savor the health benefits of cannabidiol through nasal administration, you need specially formulated CBD emulsion and a jet nebulizer.
Pros and Cons of CBD Nebulizers
You might want to resort to inhaling CBD because it provides the fastest effect. CBD can get into your lungs through smoking, vaping, and nebulizing. Unlike the first two methods, nebulization doesn’t use heating. This means that diffusion does not in any way change the chemical components of preparation (only its physical state). Therefore, you can avoid the risk of compound decomposition and the formation of harmful substances. In addition, vaping can irritate the throat and lung tissues while nebulization is not associated with such adverse effects.
On the not so bright side, special CBD nebulizers cost a pretty penny. A middle-range device would cost around $500 while budget-friendly nebulizers under $100 are really hard to come by. The cost of CBD emulsion is also higher than that of CBD oil per dose or serving. If you’re ready to put up with a relatively high price for CBD nebulizers and emulsions, then you can fully enjoy the health benefits of diffused cannabidiol.
CBD Forms of Use
Once upon a time, you could ask Google for tips on “how to take CBD” and come up empty.
Today, CBD is pretty much everywhere. CBD or cannabidiol is a therapeutic and non-intoxicating compound found in hemp and cannabis. A variety of products such as CBD gummies, oils, tinctures, beverages, topicals are continuing to grow in popularity and there’s no wonder why – CBD is prevalent among people struggling to manage stress, anxiety, pain, and other symptoms.
Non-experienced users typically associate cannabis with getting stoned, but what they don’t know is that CBD is extracted from the plant to make products that come without the high or the smoke. The cannabis compound responsible for the “high” effect is called tetrahydrocannabinol or THC, and thanks to numerous extraction methods we can now enjoy cannabis-derived CBD products with little to no THC for clearer-headed symptom relief.
How do we take CBD oil and other products?
CBD forms of use are really varied– you can smoke it, vaporize it, ingest it as an oil, or apply it as a lotion. All these options make it easier for people to integrate CBD into their lifestyle. Yet, although all these products deliver cannabidiol, they don’t all work in the same way. Some delivering techniques are most suited to different conditions, so it’s a smart move to familiarize yourself with every available option.
Any good CBD product starts with good CBD oil. It’s the gist of any product you’re going to try, so make sure whichever CBD oil you choose comes from organic hemp, if possible, grown locally. CBD is commonly found as a liquid extract in bottles with a dropper attached to the lid – also called tinctures. You can mix CBD oil directly into drinks and foods or even drop it under the tongue for faster absorption.
CBD oil can also be found as gel caps, which you can swallow like a supplement, but the effects will take a bit longer to kick in. CBD oils are generally used for a wide range of symptoms, including anxiety, stress, pain, and sleeplessness.
When using CBD edibles, you want to find products crafted with ingredients that collaborated well with cannabidiol. For instance, you can drop oil under your tongue, absorb CBD, sometimes COQ10 or curcumin, yet you can’t absorb as many antioxidants here as your stomach can.
For this exact reason, gummies have become so successful. It’s not enough for brands to wrap CBD in high-fructose corn syrup and place it on the market. People need unique products that deliver additional health benefits. And, because they can be long-lasting in effect, edibles are most popular among people managing stress, pain, and inflammation. Regarding their potency, CBD gummies have been found the most reliable form when it comes to delivering the advertised dose.
CBD topicals and lotions
As the name suggests, CBD topicals are products you can easily spread on the skin for localized relief of inflammation, soreness, pain, and possible headaches. Oils, gels, balms, creams, sprays, lubes… topicals come in every “how” for anyone. While some topicals contain water and absorb faster, others are oil-based, so they absorb more deeply.
Along with CBD, you’ll also frequently find ingredients like capsaicin, menthol, camphor, cayenne, or anti-inflammatory cannabinoids such as THCA in topicals. If you have a cannabis-free topical you already prefer, then try to find a topical with similar ingredients.
When it comes to vaporizing CBD, it’s difficult to go wrong – as long as you follow simple and basic steps. Most likely, you’ve heard some stories over the past couple of years about cannabis vaporizers causing some detrimental side effects. This was caused solely by an additive known as Vitamin E acetate, which most of the knockoff brands relied on to manufacture vape cartridges. Yet, it doesn’t imply that all brands are the same.
Vaporized CBD is known to provide fast-acting effects which makes it ideal for those in need of prompt relief from symptoms like pain and anxiety. To the fun part, vaping is one of the most widespread delivery methods because it provides excellent bioavailability and is genuinely delicious.
While, indeed, vaping CBD is all about delivering the buoyant relaxation and calm the compound brings, it’s also about the flavours.
Pearl2o™ NEBULIZER SYSTEM
Leading the Evolution of Cannabis Delivery
The Pearl2o™ Nebulizer System is specifically designed for exclusive use with Pearl2o™ Vitamin Water based applications.
Pearl2o™ Nebulizer System Benefits:
- Fast and precise delivery medical grade, smoke-free and oil-free delivery of cannabis
- Extremely gentle delivery with no cannabis taste, odor, or flavor
- Discrete, quick and timely delivery of water-based medical and non-medical cannabis applications and products
- Virtually silent operation
- Extremely compact and portable
- Powered by a single set of AA batteries
- Available optional AC adapter
- Medical grade and BPA-free components
Pearl2o™ Nebulizer System and PEARL2O™ water are powered by is by Sōrse™, a one-of-its-kind Advanced Cannabis Emulsion technology.
Sōrse™ and Pearl2o™ vitamin water enable the delivery of smoke-free and oil-free, water-based, medical grade cannabis experiences.
PLEASE CONTACT US FOR MORE INFORMATION AT [email protected]
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Washington Disclaimer: This product has intoxicating effects and may be habit forming. Marijuana can impair concentration, coordination, and judgement. Do not operate a vehicle or machinery under the influence of this drug. There may by health risks associated with consumption of this product. For use only by adults twenty-one and older. Keep out of reach of children. Washington State 502 Pesticide Disclaimer: No Pesticides were used in the cultivation, extraction, or infusion of this product.
CA license(s): Rec: CDPH-T00000697, Med: CDPH-T00000696
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