How can CBD help that is cannabidiol Polymyalgia Rheumatica Pain?
How can CBD help that is cannabidiol Polymyalgia Rheumatica Pain?
Polymyalgia rheumatica is a condition that causes muscle mass stiffness and pain in the shoulders and is described as irritation. Other signs are aches, tightness each morning and discomfort in the top hands, throat, thighs, sides, wrists, elbows and knees and restricted range of flexibility into the affected areas. Polymyalgia is known become a disease that is autoimmune. It is almost always addressed having a dose that is low of corticosteroids which might be paid off slowly after a few weeks. Medical practioners https://cbdoilmarketplace.net/ also prescribe calcium and vitamin D supplements to stop bone tissue less and quite often a suppressant that is immune. The medications result serious side-effects this kind of fat gain, diabetes, high blood pressure, clouding associated with attention contacts and weakening of bones. If flexibility is restricted the patients may go through physiotherapy also. For pain, which happens to be chronic, clients of polymyalgia use either prescription drugs or higher the countertop discomfort medicines. These too include a long selection of side effects and opioids, that are commonly recommended, come with all the danger of addiction and overdose as well as death.
The situation with pharmaceuticals is the fact that side effects require additional medications to fight them and those drugs that are secondary cause opposite side results that could require a lot more medications to suppress them. A patient may end up taking two dozen or more pills per day in the end. This produces dependency, addiction and much more wellness problems.
Which is why there clearly was fascination with natural remedies that could relieve the stiffness and pain without undesirable side-effects. Seniors would be the quickest growing populace group that is utilizing CBD services and products for age-related dilemmas such as for example polymyalgia rheumatica. CBD is of particular interest at this time because it has numerous health advantages including relief of pain and reduced amount of infection. In accordance with medical findings, CBD will not work entirely on CB1 and CB2 receptors but appears to work by boosting your body’s power to make use of a lot more of its very own endocannabinoids. That is exactly just how it manages to own health that is many such as the pain relief and swelling in cases of polymyalgia.
Though CBD will be examined for a great deal of health problems, scientists have scarcely viewed it as an answer for polymyalgia rheumatica. Consequently, scientific studies are needed for this condition that is particular.
CBD is Anti-inflammatory and Analgesic
CBD is anti inflammatory so that it works well in relieving the outward symptoms of polymyalgia by reducing irritation. Currently it really is getting used to take care of the pain sensation this is certainly related to arthritis plus it functions by reducing swelling. Numerous joint disease clients are speaing frankly about the higher level of relief which they have from CBD plus they are motivating others to test it. Analysis on infection is promising. As an example, an animal study posted last year discovered that CBD paid down irritation by changing the method that discomfort receptors respond to stimuli. It paid off discomfort.
Polymyalgia rheumatica is seen as an stiffness and pain of muscle tissue. Happily, CBD is just a well-known analgesic. In reality, cannabis ended up being utilized as a discomfort killer for a time that is long it had been prohibited when you look at the western because of the punishment regarding the psychoactive cannabis varieties. Low-THC cannabis currently getting used to deal with discomfort related to cancer tumors, discomfort related to joint disease, along with other types of chronic discomfort. In a report involving rats and mice posted when you look at the Journal of Experimental Medicine, CBD remarkably paid off pain that is chronic infection when you look at the pets. A combination of THC and CBD brought notable pain relief in a study involving 177 people with pain related to cancer that could not be relieved by pharmaceutical drugs. Nabiximols (Sativex), a medication authorized in the uk and Canada for multiple sclerosis discomfort, is made of a mixture of THC and CBD.
Since polymyalgia rheumatica involves lots of muscle tissue discomfort, CBD is just an analgesic that is welcome will perhaps not bring any unfavorable unwanted effects. It’s a remedy that is powerful the two major issues with polymyalgia, in other words. pain and infection. Patients who cannot tolerate the medial side results from pharmaceuticals can properly use CBD. It appears to be like CBD coupled with THC may become the fix for chronic discomfort later on.
CBD Enhances Appetite
A few of the the signs of polymyalgia rheumatica are lack of appetite and unintended fat reduction. CBD is well known to enhance appetite plus the wellness regarding the tract that is digestive. While clients usually takes it for infection and pain, additionally they reap the benefits of improved appetite and recovery of the intestinal tract, ultimately causing better eating, better digestion and enhanced consumption of nutritional elements and that leads to better health insurance and fat gain.
CBD Brings Welcome Relief of Despair
Some patients of polymyalgia rheumatica suffer with depression possibly as a result of the discomfort and limited motion. CBD is well known to alleviate despair. Once the clients just take CBD for discomfort and swelling in addition they reap the benefits of relief of despair, ultimately causing a far better enjoyment of life.
CBD Relaxes Mind And Body
CBD relaxes the muscles that are stiff bones in clients struggling with polymyalgia rheumatica. By relaxing the muscle tissue, the patients can better move their limbs. By relaxing their body and mind the patients can sleep better.
CBD Heals Autoimmune Diseases
Polymyalgia is suspected to be an autoimmune infection. Luckily, CBD is currently known to enhance the outward indications of other conditions that are autoimmune as numerous sclerosis and arthritis rheumatoid. Consequently, those who experience polymyalgia rheumatica can find the desired also relief.
Individuals with Polymyalgia Rheumatica Can Benefit from CBD!
Though research to the usage of CBD for polymyalgia rheumatica continues to be scant, research into other chronic conditions and autoimmune diseases is proving that CBD is an efficient and remedy that is safe. Clients with polymyalgia rheumatica have numerous alternatives in terms of CBD items. They are able to select non-smokable distribution techniques such as for example edibles, capsules, softgels, tinctures, topicals and vaporisers. They don’t have to be concerned about side-effects since the known side-effects start around mild to moderate. In reality, studies have found that CBD has a rather safety that is good in comparison to pharmaceuticals. Patients just have actually to be concerned about the grade of CBD that they can research before investing in any brand that is particular.
Does CBD Oil Work For Polymyalgia Rheumatica (PMR)? 5 Clinical Studies Say Yes!
Today’s article seeks to answer a simple query. Does CBD oil work for Polymyalgia Rheumatica (PMR)? In order to answer this query successfully and determine the effectiveness of CBD oil and cannabis-based treatment, we need to understand what Polymyalgia is.
What Is Polymyalgia Rheumatica?
Polymyalgia is an inflammatory disorder. It causes pain and stiffness in your muscles, joints, and soft tissue. The word polymyalgia means “pain in many muscles”. The word ‘poly’ means ‘many’ and ‘myalgia’ means ‘muscle pain’. The areas of your body most likely to be affected by Polymyalgia are your shoulders, neck, and hips. Polymyalgia rarely develops in people under the age of 50. It commonly develops in people above 50 years old and the average age of onset is about 70 years old.
What Causes Polymyalgia Rheumatica?
The cause of polymyalgia is unknown within the medical community. Polymyalgia is believed to be an autoimmune disease. An autoimmune disease is one where your body’s immune system attacks its own healthy cells. In the case of polymyalgia, the immune system attacks your joint tissue and muscle cells causing inflammation, pain, and stiffness.
The medical community suspects that genetics and environmental factors play a role in the onset of polymyalgia. It is believed that certain genes and gene variations increase your susceptibility to getting polymyalgia. Cases of polymyalgia tend to be cyclical in nature leaning towards seasonal triggers. A potential environmental trigger such as a virus is suspected to play a role, but no specific virus has been shown to cause of polymyalgia. Thus, its specific cause is still a mystery.
According to the American College of Rheumatology:
What Are The Symptoms Of Polymyalgia Rheumatica?
As stated earlier, the areas of your body most likely to be affected by Polymyalgia are your shoulders, neck, and hips. Symptoms of polymyalgia include severe stiffness and pain in your neck, shoulder, and hip muscles. Symptoms usually develop quickly, occur on both sides of your body, and tend to be worse in the morning or after long periods of inactivity.
Patients also report flu-like symptoms including fever, weakness, fatigue, depression, and weight loss. Though polymyalgia is an inflammatory disorder, it does not cause swelling in the joints or muscles. This makes polymyalgia difficult to identify.
About 15 percent of patients with polymyalgia develop a condition known as Giant Cell Arteritis (GCA). GCA is the inflammation of the arteries in your head, most often your temples. GCA can cause headaches, vision difficulties, jaw pain, and scalp tenderness. And, it is possible to have polymyalgia and GCA at the same time.
What Is The Current Treatment For Polymyalgia?
Doctors use blood tests to detect inflammation because polymyalgia does not cause muscle or joint swelling. Tests would result in abnormally high inflammation in your blood. But before doctors can diagnose you with polymyalgia, they need to rule out other conditions such as rheumatoid arthritis.
If your doctor suspects polymyalgia, you’ll receive a low-dose of corticosteroids such as Prednisone. This helps reduce inflammation. If polymyalgia is present then stiffness can be alleviated in as fast as one dose. However, some patients report a slow response rate. Typically, a patient is on corticosteroids for a few months to a year under the supervision of their doctor.
According to the American College of Rheumatology, non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen are said to be ineffective for polymyalgia treatment. Yet, according to Musculoskeletal Australia, NSAIDs and OTC pain medication can provide temporary relief of pain and stiffness.
The problem with corticosteroids is that they cause unwanted side effects, especially with long-term use. Potential side effects include high cholesterol, weight gain, loss of bone density and strength (osteoporosis), high blood pressure (hypertension), diabetes, and the clouding in your eye lenses (cataracts).
To counteract the side effects, your doctor will recommend a daily vitamin D and calcium supplement. Supplements are normally recommended if you take corticosteroids for more than 3 months. Due to the negative side profile of corticosteroids, patients are looking for alternative solutions. One of the solutions being considered is cannabis-based treatment in the form of CBD oil. This leads us to the question of the day…
Does CBD Oil Work For Polymyalgia?
Yes, CBD oil does work for the treatment of Polymyalgia. More specifically, CBD oil will help with treating inflammatory and pain symptoms associated with Polymyalgia. Cannabis-based treatment is scientifically proven to provide anti-inflammatory and pain relief effects in human clinical trials.
How Effective Is CBD Oil For Treating Inflammation In Polymyalgia?
We established earlier that Polymyalgia is an inflammatory disorder, which the medical community believes is autoimmune in nature. Hence, to answer the above question, we need to look at the results of a 2000 collagen-induced arthritis rodent study and a 2005 rheumatoid arthritis patient study. The results from these two studies will help you understand how effective cannabis-based treatment is for inflammation in Polymyalgia.
In the year 2000, a rodent model study was conducted to determine the effectiveness of cannabidiol (CBD) treatment in mice with collagen-induced arthritis (CIA). Arthritis is an inflammatory disorder similar to polymyalgia that causes pain and stiffness in your joints that worsens with age. The results this study presents reflects how cannabis-based medicines will interact with Polymyalgia.
After inducing arthritis in the mice, CBD was administered as soon as signs of clinical symptoms were clear and evident. The mice were administered with CBD daily for 10 days either through injection or orally. The mice that received CBD via injection were broken down into the following groups:
- Group 1: 12 mice received 20 mg/kg of CBD in ethanol/cremophor and saline
- Group 2: 17 mice received 10 mg/kg of CBD in ethanol/cremophor and saline
- Group 3: 15 mice received 5 mg/kg of CBD in ethanol/cremophor and saline
- Group 4: 9 mice received 2.5 mg/kg of CBD in ethanol/cremophor and saline
- Group 5: 23 mice received 0 mg/kg of CBD, just ethanol/cremophor and saline (control group)
The mice that received CBD via oral administration were broken down into the following groups:
- Group 1: 6 mice received 10 mg/kg of CBD in olive oil
- Group 2: 6 mice received 25 mg/kg of CBD in olive oil
- Group 3: 6 mice received 50 mg/kg of CBD in olive oil
- Group 4: 6 mice received 0 mg/kg of CBD, just olive oil (control group)
The study found that CBD was equally effective for treatment when administered via injection or orally. The study also found that daily administration of CBD in mice with collagen-induced arthritis (CIA) via both modes of treatment effectively blocked the progression of arthritis. The optimal daily dosages for the mice was 5 mg/kg via CBD injection, and 25 mg/kg via CBD oral administration.
The study highlighted that clinical improvement was associated with protection of the joints against severe damage. The data uncovered in this study shows that CBD has a potent anti-arthritic effect though its immunosuppressive and anti-inflammatory actions. This suggests that CBD is a valuable treatment option for other (chronic) inflammatory diseases.
In the year 2005, a rheumatoid arthritis (RA) patient study set out to investigate the effectiveness of a cannabis-based medicine called Sativex. The study’s focus was on the pain relief effects Sativex could provide patients. However, it’s worth noting that rheumatoid arthritis is an inflammatory autoimmune disease that causes joint damage, joint pain, inflammation, swelling, tenderness, and stiffness throughout your body.
Sativex is a cannabis-based medicine with a 1:1 ratio of CBD and THC dominating the solution. Sativex contains other minor cannabinoids as well. Sativex and a placebo were administered to a group of 58 rheumatoid arthritis patients over a period of 5 weeks via an oromucosal spray. 31 patients received Sativex while 27 patients received the placebo.
Results from the study showed that patients who were administered with Sativex displayed a significant improvement in the following areas:
- Pain on movement (reduced)
- Pain at rest (reduced)
- Quality of sleep (improved)
However, what was more interesting is that arthritis activity was significantly suppressed following Sativex treatment. If you remember, rheumatoid arthritis is an inflammatory autoimmune disease. This suggests that Sativex not only showed pain-relief effects but anti-inflammatory effects as well, which is to the point of this article. The study highlights that the suppression of inflammatory activity indicates an influence on the immune effector system. This is consistent with the results from the rodent model study covered earlier where CBD suppressed the progression of arthritis in mice. The data from this study shows that CBD also suppresses the progression of arthritis in humans as well.
In addition to the above studies, commentary from a 2018 peer-reviewed journal points to CBD being beneficial for multiple inflammatory disorders. The journal states that:
“CBD has been demonstrated to be useful in the treatment of different inflammatory ailments, including bowel diseases (e.g., Crohn’s and ulcerative colitis), neuronal diseases (e.g., Parkinson and Alzheimer), and a wide range of inflammatory skin diseases (e.g., atopic dermatitis and psoriasis)”.
Federica Pellati, Vittoria Borgonetti, Virginia Brighenti, Marco Biagi, Stefania Benvenuti, Lorenzo Corsi, “Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer”, BioMed Research International, vol. 2018, Article ID 1691428, 15 pages, 2018. https://doi.org/10.1155/2018/1691428
The journal adds that not only can CBD interfere with the progress of inflammatory disorders but it can also interfere with the progress of cancer cells. The journal states that:
How Effective Is CBD Oil For Providing Pain Relief In Polymyalgia?
This question was already answered in the results found in the 2005 rheumatoid arthritis patient study. However, it doesn’t hurt to add more studies for additional support. We’ll look at the results of a 2019 fibromyalgia patient study and the results of a 2010 cancer patient study, which both focus on pain relief. The results of these studies will help you understand just how effective cannabis-based treatment is for pain relief Polymyalgia.
Fibromyalgia is a chronic pain syndrome that causes widespread muscle and joint pain, muscle tenderness, joint stiffness, physical sensitivity, fatigue, and a few other symptoms. The focus of the 2019 study was to investigate the impact cannabis-based treatment had on pain symptoms caused by fibromyalgia.
The study tested 3 variants of cannabis-based medicines and 1 placebo on the patients. The first group of patients were administered with Bedrocan, which had 22.4mg THC and less than 1mg CBD. The second group of patients were administered with Bediol, which had 13.4mg THC and 17.8mg CBD. The third group of patients were administered with Bedrolite, which had less than 1mg THC and 18.4mg CBD. The fourth and final group of patients were administered a placebo, which had neither THC nor CBD in it.
Results from the study found that patients administered with THC and CBD in a 1:1 ratio (Bediol) experienced the most significant pain relief effects. The minimum amount of pain relief was measured at 30 percent or more. The next group to experience significant pain relief effects was the THC dominant group (Bedrocan). And, the last two groups being the CBD dominant group (Bedrolite) and the placebo group reported similar pain relief results. Though similar, the CBD dominant group reported slightly more pain relief effects than the placebo group.
The study concluded that significant pain relief effects are experienced in cannabis-based treatments. The most notable being in the 1:1 ratio of THC and CBD followed by the THC dominant solution and then by the CBD dominant solution. The researchers pointed out that, in their experience, and in that of other researchers, patients with chronic pain report beneficial effects from CBD only treatment. Hence, either a single administration of CBD is insufficient or the dose amounts of CBD in this study were too low to elicit pain relief effects.
Now if you’re unaware, cancer can cause pain in your joints, muscles, soft tissue, and bones. The type of cancer that causes these ailments is called ‘blood cancer’. Examples of blood cancer include leukimia, lymphoma, and myeloma.
The focus of the 2010 cancer patient study was to investigate the effectiveness of cannabis-based treatment on patients with advanced cancer pain. These patients got inadequate pain relief effects from prior strong opioid treatment. The study tested 2 variants of cannabis-based medicine and 1 placebo. The cannabis-based variants included a CBD and THC extract (in a 1:1 ratio), and a THC dominant extract.
After analyzing symptoms before and after treatment over a 2-week period, the study found that the patients taking the CBD and THC extract reported a minimum reduction in pain by 30 percent or more. In this study, the patients taking the THC dominant extract showed similar pain relief results to the placebo group. The study concluded that THC and CBD in a 1:1 ratio is effective for pain relief in patients with advanced cancer pain who were not fully relieved via strong opioid treatment.
CBD oil and cannabis-based medicines are effective and useful for the treatment of Polymyalgia. Specifically in regards to providing effective pain relief and anti-inflammatory effects. The studies highlighted in today’s article clearly show how effective cannabis-based treatment is for treating the major symptoms of Polymyalgia, which are pain and inflammation.
There should NOT be a doubt in your mind, moving forward, that you will be able to achieve effective treatment results from CBD oil use for inflammation and pain. Your only challenge is in finding a suitable CBD oil solution that will assist you in getting results.
Regarding inflammation, CBD alone has been scientifically proven to provide anti-inflammatory effects. However, regarding pain, the best scientifically proven solution is CBD and THC in a 1:1 ratio. This will be challenging to find commercially as current regulation limits the amount of THC availability to either 0.3% or 0.2% in a given CBD oil product based on your location.
Researchers have stated that high enough doses of CBD dominant solutions can provide pain relief effects. Yet, what those dose levels look like are unclear at the moment. Hence, it is best to work with a pro-cannabis medical professional to guide you through the process of finding your optimal dosage levels so you can achieve your desired results.
If a pro-cannabis medical professional is inaccessible to you in your area, then you may need to consider microdosing as your next option. As an example, microdosing marijuana is the practice of taking small amounts in order to reap the medical benefits of THC while avoiding its psychoactive effects. However, instead of microdosing marijuana, you may look into microdosong CBD oil to find your optimal dosage that produces the desired effects and results for you.
You would need to keep an active journal on hand to take note of a few variants such as:
- The type of cannabis product purchased (oil, vape, flower, edibles, etc)
- The CBD and/or THC concentration levels (number of mg’s per bottle)
- The date of treatment commencement (start date)
- The times of treatment administration (times of day, AM and PM)
- The frequency of treatment administration per day (number of times per day)
- The dosage amounts per administration (number of milligrams or drops per dose)
- The noticeable effects after administration (positive, negative, or neutral)
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