cbd oil for yeast

CBD Oil for Yeast Infection: Proven Home Remedies to Treat, Conquer and Heal Fungus and Yeast Infection Paperback – 24 August 2019

In one study from 2008, researchers concluded that four major cannabinoids:

  • Cannabidiol (CBD)
  • Cannabichromene (CBC)
  • Cannabigerol (CBG)
  • Cannabinol (CBN)

all show “potent activity” against bacteria like MRSA.

These results seem to, in part, back up a 1981 study in which CBC was tested as an antibacterial and antifungal on rats. The researchers concluded that CBC has strong antibacterial activity and mild to moderate antifungal properties.

A 2011 study further explain that while CBD, CBG and CBC are all just moderate antifungal agents, these three cannabinoids may increase the power of caryophyllene oxide, a highly effective antifungal. According to the study, CBG and CBC both eradicated a common fungal infection in humans in 15 days. This is a comparable rate to many pharmaceutical antifungal drugs.

Cannabis’s Anti-Itch & Anti-inflammatory Properties Can Ease Vaginal Infection Symptoms

The power of cannabis as an anti-inflammatory is one of the most widely known medical applications of the plant. And while the body of research on cannabis as an anti-inflammatory isn’t directly connected to vaginal infections, much of the uncomfortable symptoms of vaginal infections are directly associated with inflammation.

Inflammation can not only cause pain, but also itching, which is a common symptom of most vaginal infections. A study looked into the role of cannabinoids in dermatology.

The lead researcher noted that of all the applications for cannabinoids in dermatology, perhaps the “most promising role for cannabinoids is the treatment of itch.” He notes that in one study, eight of 21 people who applied cannabinoid cream twice a day for three weeks saw a complete elimination of severe itching

From wet wipes to CBD oil…8 things you should NOT put near your vagina

MODERN science tells us the vagina is a delicate, self-cleaning machine that generally does fine if it's left alone.

However, many women still insist on putting things near it that they shouldn't – including glitter and jade eggs.

And there are some surprising things, such as wet wipes and feminine washes, that can actually do a lot more harm than good to your lady area.

Here we talk you through the main eight items you need to avoid putting near your vagina and why.

1. Wet wipes

Women often think it's okay to use wet wipes on your private parts given their stereotypically-feminine floral packaging.

In particular, many online sites have recommended festival-goers invest in a few packets to stay clean while out camping or at a festival.

However, Dr Jen Gunter, dubbed Twitter's resident gynaecologist, says they can actually do a lot more harm than good.

She told Huffington Post: "Wipes cause skin irritation including contact dermatitis – gynaecologists see this all the time.

"Your skin is a protective layer and the more you wipe, the more you are going to irritate it.

"Why are wipes marketed to women for camping and not for men? Don’t they have asses to wipe too?

"Until they exist with men’s products, I’m going keep hammering that it is pure misogyny."

Dr Gunter instead recommends using a facial cleanser on your entire body, including your vulva, with coconut oil as moisturiser.

2. Feminine washes and sprays

Soaps, shower gels and sprays for "feminine hygiene" are a complete waste of money, and could damage your vulva – according to experts.

Dr Gunter said: "Many of them actually have scents in them. Your vulva skin is more sensitive to irritation, and fragrance is a very common trigger for irritation.

"Also, some women are using these products internally, because we don’t use the right language – we don’t say ‘vagina’ and ‘vulva’ – it’s evolved into this catch-all grey zone. If you use them internally, you can damage your vaginal ecosystem – your good bacteria."

3. CBD oil

The global CBD industry recently claimed that inserting one of their small, pill-like products into your vagina can ease period pain.

Despite this, Dr Gunter is urging women to do this with caution.

She said: "We have very little data on CBD for pain. And when there’s no data, it’s very ripe for abuse.

"What we know right now is that any cannabis product that is designed to be inserted into the vagina is untested, so you should be very wary of any company making health claims.

"How would you feel about a pharmaceutical company selling you a pill that hasn’t been tested? It’s the same thing. So I would ask people to look at it with that eye."

Dr Gunter also emphasised that research has shown that cannabis-derived products can increase risk of yeast infections.

She added: "There is some old animal data that shows it could potentially impact the sugar in the cells in the vagina, and this is super important, because sugar in the cells in the vagina is the source of food that feeds the good bacteria."

4. Cider vinegar

Women have recently started using cider vinegar, which is used in salad dressings and chutneys, in the hopes that it will tighten up their vagina.

Supporters of the method say it will not only make the vagina tighter but also shrinks the vulva – noting that it is something that women have been doing since The Dark Ages.

Unsurprisingly, however, it's a terrible idea and has prompted experts to warn women not to put vinegar anywhere near their genitals.

How to prevent yeast infections

If you do think that you have a yeast infection, the best thing to do is go to your pharmacist or a GUM clinic.

They can help work out if you really do have something like thrush and which medications might work most effectively.

You'll often need antifungal medicine to get rid of thrush.

This can be a tablet you take, a tablet you insert into your vagina or a cream to relieve the irritation.

It should clear up within a week or after you've finished your course of meds.

It's harder to get rid of an infection once you have it but there are various things you can do to prevent one in the first place:

  • Only have sex when you're aroused. Having intercourse when your vagina is dry can cause irritation and in turn, trigger an infection
  • Never douche or use "feminine hygiene" products – your vagina cleans itself
  • Avoid strong soaps and body washes
  • Avoid tight and synthetic underwear
  • Try sleeping in the buff to give your vagina a little breathing space

Anne Henderson, consultant gynaecologist, told The Sun Online: "This new trend to use cider vinegar vaginally is very worrying from a gynaecological point of view.

"Because of the different constituents in cider vinegar, including potentially sensitising additives, I would advise all women to avoid this trend like the plague.

"Any tightening effect from cider vinegar is likely to be due to localised irritation and inflammation, and as such will not cause a long lasting benefit and may potentially damage the delicate vaginal skin."

And Professor Linda Cardozo, spokeswoman for the Royal College of Obstetricians and Gynaecologists, added: "It is a myth that cider vinegar will tighten the vagina.

"Putting cider vinegar in your vagina would not only be uncomfortable but it also has the potential to cause damage and disrupt the natural flora of the vagina."

5. Glitter

The most recent vaginal trend is glitter – with women all over the country glitter-bombing their bits to make them feel "soft, sweet and magical".

An online retailer, called the Pretty Woman Inc, launched glitter-filled capsules for ladies to insert into their vaginas, claiming they make your lady parts "taste" and "look" better,

However, gynaecologists have warned against the bizarre new trend – saying this could actually lead to a dangerous infection.

Doctor Vanessa Mackay, spokesperson for the Royal College of Obstetricians and Gynaecologists (RCOG) said: "The vagina contains a delicate balance of good bacteria, which are there to protect it.

"If women place foreign objects inside their vagina, they risk disturbing this balance which may lead to infection, such as bacterial vaginosis or thrush, and inflammation."

And consultant obstetrician and gynaecologist Shazia Malik agreed, saying that the ingredients used in these capsules could cause painful inflammatory discharge and even tiny scratches to the vagina.

She added: "Using a product like this so called passion dust might actually kill off any passion at all."

6. Jade eggs

Gwyneth Paltrow recently claimed on her site Goop that jade eggs can improve your sex life and balance your menstrual cycle.

Despite this, experts say the product is a "scam" and can even increase the risk of developing toxic shock syndrome.

Dr Gunter said: "Jade eggs are a scam. Why would you trust someone who is trying to sell you an actual proven scam?

"We don’t know how to take care of it so that we’re not re-introducing bacteria into the vagina and risking toxic shock syndrome.

"If you want to strengthen your pelvic floor, there are great ways to do that. You can do kegel exercises for free."

If you do want to use a vaginal weight, Dr Gunter recommends buying a medical-grade product that’s silicone or plastic and easy to clean.

She added: "Some of them look very sexy if you want to incorporate them into sexual play.

"You can also buy a great quality vibrator for less than a jade egg – just saying – and it’s probably going to do a lot more for your sexual health."

7. Parsley

Aside from the total lack of evidence, herbal inserts can be really dangerous.

“It’s a bad idea to insert anything not prescribed by a practitioner inside your vagina. Your vagina has a natural healthy balance which can be upset by the introduction of foreign objects," Karin O’Sullivan, Clinical Lead at FPA Charity told The Sun.

“When it comes to plants, hygiene can be an issue, with the introduction of new bacteria.

"Herbal inserts have not been medically tested and cannot be considered safe. As they’re untested, there’s also no guarantee of any health benefits.

"There is no evidence to suggest that taking parsley orally, or vaginally, will help to induce a period.

"More importantly, there is a risk that introducing foreign objects to the vagina can cause infections and even lead to toxic shock syndrome if left inside, which can be deadly."

In fact, a pregnant woman died last year after inserting parsley stems into her vagina in a botched bid to induce a miscarriage.

8. Cucumber

Bloggers, vloggers and a number of alternative health therapists have encouraged women to "cleanse" their vaginas with cucumber – but ONLY after peeling it (a thinly veiled attempt at safety advice, perhaps).

They claimed that it can "help sanitise and maintain a pleasant odour", as well as potentially warding off STIs.

Yeast produce low-cost, high-quality cannabinoids

UC Berkeley synthetic biologists have engineered brewer’s yeast to produce marijuana’s main ingredients—mind-altering THC and non-psychoactive CBD—as well as novel cannabinoids not found in the plant itself.

Feeding only on sugar, the yeast are an easy and cheap way to produce pure cannabinoids that today are costly to extract from the buds of the marijuana plant, Cannabis sativa.

“For the consumer, the benefits are high-quality, low-cost CBD and THC: you get exactly what you want from yeast,” said Jay Keasling, a UC Berkeley professor of chemical and biomolecular engineering and of bioengineering and a faculty scientist at Lawrence Berkeley National Laboratory. “It is a safer, more environmentally friendly way to produce cannabinoids.”

Cannabis and its extracts, including the high-inducing THC, or tetrahydrocannabinol, are now legal in 10 states and the District of Columbia, and recreational marijuana—smoked, vaped or consumed as edibles—is a multibillion-dollar business nationwide. Medications containing THC have been approved by the Food and Drug Administration to reduce nausea after chemotherapy and to improve appetite in AIDS patients.

CBD, or cannabidiol, is used increasingly in cosmetics—so-called cosmeceuticals—and has been approved as a treatment for childhood epileptic seizures. It is being investigated as a therapy for numerous conditions, including anxiety, Parkinson’s disease and chronic pain.

But medical research on the more than 100 other chemicals in marijuana has been difficult, because the chemicals occur in tiny quantities, making them hard to extract from the plant. Inexpensive, purer sources—like yeast—could make such studies easier.

Plus, he added, there is “the possibility of new therapies based on novel cannabinoids: the rare ones that are nearly impossible to get from the plant, or the unnatural ones, which are impossible to get from the plant.”

Keasling, the Philomathia Foundation Chair in Alternative Energy at Berkeley, and his colleagues will report their results online Feb. 27 in advance of publication in the journal Nature.

Plugging chemical pathways into yeast

Cannabinoids join many other chemicals and drugs now being produced in yeast, including human growth hormone, insulin, blood clotting factors and recently, but not yet on the market, morphine and other opiates.

Researchers feed sugar to genetically engineered yeast and get out THC, CBD and other cannabinoids normally produced only by marijuana plants. (Graphic by Amy Cao)

One of the pioneers of synthetic biology, Keasling has long sought to exploit yeast and bacteria as “green” drug factories, eliminating the expensive synthetic or extractive processes common in the chemical industry and the often toxic or environmentally- damaging chemical byproducts.

Cannabis cultivation is a prime example of an energy-intensive and environmentally-destructive industry. Farms in northwest California have polluted streams with pesticide and fertilizer runoff and helped drain watersheds because marijuana plants are water-hungry. Illegal grows have resulted in clear-cutting and erosion.

Indoor cultivation under grow lights with ventilation fans uses a lot of energy, accounting for a growing percentage of annual power consumption. One study estimated that California’s cannabis industry accounted for 3 percent of the state’s electricity usage. Indoor grows have caused blackouts in some cities, and energy consumption can add more than $1,000 to the price of a pound of weed.

Hence Keasling’s interest in finding a “green” way to produce the active chemicals in marijuana.

“It was an interesting scientific challenge,” he admitted, that was akin to other challenges he and his team have successfully overcome in yeast: producing an antimalarial drug, artemisinin; turning plant waste into biofuels; synthesizing flavors and scents for the food and cosmetics industries and chemical intermediates for making new materials. “But when you read about cases of patients who have seizures and are helped by CBD, especially children, you realize there is some value in these molecules, and that producing cannabinoids in yeast could really be great.”

With approval and oversight by the U.S. Drug Enforcement Administration —cannabis is still illegal under federal law—Berkeley postdoc Xiaozhou Luo and visiting graduate student Michael Reiter, who led the project, started assembling in yeast a series of chemical steps to produce, initially, the mother of all cannabinoids, CBGA (cannabigerolic acid). In both marijuana and yeast, the chemical reactions involve the acid form of the compounds: CBGA and its derivatives, THCA and CBDA. They readily convert to CBG, THC and CBD when exposed to light and heat.

Turning yeast into chemical factories involves co-opting their metabolism so that, instead of turning sugar into alcohol, for example, yeast convert sugar into other chemicals that are then modified by added enzymes to produce a new product, such as THC, that the yeast secrete into the liquid surrounding them. The researchers ended up inserting more than a dozen genes into yeast, many of them copies of genes used by the marijuana plant to synthesize cannabinoids.

One step, however, proved to be a roadblock for Keasling’s group and competing groups: an enzyme that performs a key chemical step in making CBGA in the marijuana plant didn’t work in yeast.

To produce cannabinoids in yeast, Berkeley synthetic biologists first engineered yeast’s native mevalonate pathway to provide a high flux of geranyl pyrophosphate (GPP) and introduced a hexanoyl-CoA biosynthetic pathway combining genes from five different bacteria. They then introduced Cannabis genes encoding the enzymes involved in olivetolic acid (OA) biosynthesis, a previously undiscovered prenyl transferase enzyme and cannabinoid synthases. The synthases converted cannabigerolic acid (CBGA) to the cannabinoid acids THCA and CBDA, which, upon exposure to heat, decarboxylate to tetrahydrocannabinol (THC) and cannabidiol (CBD), respectively.

Rather than engineer a different synthetic pathway, Berkeley postdoc Leo d’Espaux and graduate student Jeff Wong went back to the plant itself and isolated a second enzyme, prenyl transferase, that does the same thing, and stuck it in the yeast.

“It worked like gangbusters,” Keasling said.

Once they had yeast-producing CBGA, they added another enzyme to convert CBGA to THCA and a different enzyme to create a pathway to CBDA. Though the products the yeast produce are predominantly THC or CBD, Keasling said, each must still be separated from other chemicals present in tiny quantities.

They also added enzymes that made the yeast produce two other natural cannabinoids, CBDV (cannabidivarin) and THCV (tetrahydrocannabivarin), whose effects are not well understood.

Surprisingly, Xiaozhou and Michael discovered that the enzymatic steps involved in making CBGA in yeast are flexible enough to accept a variety of starter chemicals—different fatty acids in place of the one used by the marijuana plant, hexanoic acid—that generate cannabinoids that do not exist in the plant itself. They also got the yeast to incorporate chemicals into cannabinoids that could later be chemically altered in the lab, creating another avenue for producing never-before-seen, but potentially medically useful, cannabinoids.

Keasling subsequently founded an Emeryville, California, company, Demetrix Inc., which d’Espaux and Wong later joined, that licensed the technology from Berkeley to use yeast fermentation to make cannabinoids.

“The economics look really good,” Keasling said. “The cost is competitive or better than that for the plant-derived cannabinoids. And manufacturers don’t have to worry about contamination—for example, THC in CBD—that would make you high.”

The work was supported by the National Science Foundation (1330914). Other co-authors of the paper are Charles Denby, Anna Lechner, Yunfeng Zhang, Adrian Grzybowski and Kai Deng of UC Berkeley and Simon Harth, Weiyin Lin, Hyunsu Lee, Changhua Yu, John Shin, Veronica Benites, George Wang, Edward Baidoo, Yan Chen, Ishaan Dev and Christopher Petzold of Berkeley Lab.