does cbd oil work for depression

CBD for Depression – February 2022

CBD is known to help treat various ailments, including psychiatric conditions.

Several studies have shown that CBD may help relieve the clinical signs of depression. Researchers have noted that CBD may also help alleviate anxiety, a depression symptom.

In a 2011 study, patients with a social anxiety disorder (SAD) were subjected to a simulation public speaking test and given 600 milligrams (mg) of CBD.

Results showed that patients who were pretreated with CBD experienced significant improvement in their symptoms than those who took a placebo (5 ) .

Additionally, patients who took CBD reported reduced anxiety, cognitive impairment, and discomfort when giving their speech .

Another study has noted that CBD may help alleviate the symptoms of neuropsychiatric disorders, like epilepsy and schizophrenia.

According to the researchers, CBD has the potential to calm the central nervous system (6 ) . The same findings were reported by a 2015 study (7 ) .

The 2015 study observed CBD’s therapeutic effects on generalized anxiety disorder (GAD), social anxiety disorder (SAD), panic disorder (PD), obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD).

A study published in the journal CNS & Neurological Disorders Drug Targets outlined the benefits of CBD (8 ) . The research highlighted CBD not only as an anxiolytic treatment but also as an antidepressant that treats the symptoms of depression.

Moreover, CBD’s stress- and anxiety-reducing properties may be responsible for its potential to help with high blood pressure .

The study suggested that CBD may alleviate depression, epilepsy , schizophrenia, substance abuse and dependence, social phobia, bipolar disorder, PTSD, Parkinson’s disease, and sleep disorders (9 ) .

A journal outlined the case of a 16-year old male with multiple substance use disorders. He also had severe depression, social phobia, and narcissistic personality disorder (10 ) .

The adolescent’s treatment with antidepressants has proven unsuccessful, so he sought help from a public clinic in 2018.

In the study, the researchers administered CBD capsules in various dosages for eight weeks. The patient’s simple phobias and symptoms of depression , anxiety, paranoia, and dissociation improved.

Without withdrawal symptoms, the patient also quit taking illegal drugs like cannabis , cocaine, and ecstasy.

It is the first report on CBD’s positive results on patients with multiple substance use disorders.

A study published in the Journal of Cannabis Research was conducted to review the therapeutic benefits of CBD and CBD-containing compounds, like nabiximols, in treating various psychiatric disorders and cannabis dependence (11 ) .

Nabiximols is an extract from Cannabis sativa that has been purified into a 1:1 ratio of CBD and tetrahydrocannabinol ( THC ). Sativex is a brand of nabiximols.

In the research, CBD was given to the test subjects in various ways, including oral ingestion, inhalation spray, and sublingual administration (under the tongue).

The study revealed that compared to oral administration, inhaling CBD had higher bioavailability (11% to 43%). Bioavailability is the fraction of the drug that reaches the blood.

CBD and nabiximols were most effective in treating cannabis use-related disorders. The two compounds also proved promising in treating other psychiatric disorders because of their antipsychotic properties.

Results suggest that the anxiolytic and neuroprotective effects of cannabidiol and nabiximols contributed to the treatment.

In schizophrenia and psychosis cases, higher doses of CBD (above 1200 mg daily) showed potential therapeutic benefits, especially in patients with Parkinson’s disease.

The study also supported the use of CBD in treating anxiety disorders, like post-traumatic stress disorders and social performance-related anxiety.

Patients with autism spectrum disorder who received CBD also exhibited reduced hyperactivity, self-injurious behaviors, insomnia, and anxiety.

In the study, however, CBD was ineffective in treating bipolar disorder.

The authors emphasized the need for further research to determine whether CBD alone can alleviate the disorders mentioned above. Dosing may be the reason that it did not show efficacy in bipolar patients.

Still, the researchers recognize CBD and CBD compounds’ therapeutic potential in relieving symptoms of psychosis and improving cognitive impairment due to various conditions.

Another study, published in the journal Molecular Neurobiology, compared CBD to antidepressants and noted CBD’s fast-acting effects (12 ) . Unlike CBD, depression medications have a “substantial time lag” before taking effect in the body.

How CBD Works to Alleviate Symptoms of Depression

Researchers have found that CBD interacts with 5-HT1A receptors (13 ) . This interaction produces anxiolytic and antidepressant effects in the dorsolateral periaqueductal gray (dlPAG) of the brain.

The dlPAG is the region of the brain that mediates aversive emotional experiences.

A 5-HT1A receptor is a serotonin receptor subtype that can be found in the brain. When this receptor is activated, it helps in the mechanism of action of antidepressant , anxiolytic , and antipsychotic drugs (14 ) .

Postsynaptic 5-HT1A receptors are located in the brain’s areas responsible for controlling mood, cognition, and memory. Therefore, these serotonin receptors can help in the treatment of neuropsychiatric disorders (15 ) .

5-HT1A receptors are essential in curbing depression. For instance, antidepressants increase postsynaptic 5-HT1A signaling (16 ) .

Patients exhibiting suicidal behaviors were also observed to have reduced numbers of the receptor . Researchers have also concluded that the dysfunction of 5-HT1A receptors could result in depressive disorders (17 ) .

A 2010 study conducted in rodents has proven that CBD activates 5-HT1A receptors , producing anxiolytic effects in the test subjects (18 ) .

As a substance with antidepressant-like effects , CBD also aids in increasing the expression of the brain-derived neurotrophic factor ( BDNF ).

Depressed animals and humans exhibit decreased levels of BDNF (19 ) . BDNF is a protein that is essential in the growth and survival of neurons (20 ) .

A 2018 study outlined how CBD may increase t he release of BDNF , which helps in brain neuroplasticity, particularly new synaptic formation and cell proliferation (21 ) . Neuroplasticity is required to achieve antidepressant effects.

As an antidepressant , CBD may also contribute to hippocampal neurogenesis, the production of new neurons in the hippocampus .

Neurogenesis is known to aid in neural regeneration (22 ) . The regeneration process involves forming new neurons to regrow and repair the nervous tissues.

A study conducted in mice has shown that the hippocampus ‘ neuron production attenuates depression-related behaviors (23 ) .

Research published in the journal Current Neuropharmacology investigated the link between the endocannabinoid system (ECS), the formation of neurons, and antidepressants (24 ) .

The ECS regulates several functions, like mood, appetite, sleep, memory, fertility, and reproduction. CB1 and CB2 are the two central cannabinoid receptors of ECS.

The researchers observed that when CB1 and CB2 are manipulated, they can contribute to the formation of neurons in the hippocampus .

Three types of cannabinoids interact with the ECS, namely endocannabinoids, phytocannabinoids, and lab-derived cannabinoids .

The body produces endocannabinoids. Meanwhile, phytocannabinoids (CBD and THC ) are derived from the cannabis or marijuana plant.

A study in 2018 was conducted on cannabis users. According to the research, prolonged use of cannabis can have detrimental effects on the hippocampus , primarily due to the THC component (25 ) .

The study revealed that CBD has neuroprotective properties that may reverse these effects. It also suggested that CBD may help in hippocampal neurogenesis. Researchers noted that CBD’s pro neurogenic action may have anxiolytic effects.

The 2018 study recommended that CBD may be used in alleviating cannabis dependence and several psychiatric disorders involving hippocampal pathologies. These disorders include schizophrenia, Alzheimer’s, and major depressive disorder.

CBD vs. Antidepressant Medications

Psychiatric disorders, like depression, should not be left untreated as they can worsen. Depression is usually treated by selective serotonin reuptake inhibitors (SSRIs) or antidepressants .

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SSRIs are prescription drugs and cannot be bought over the counter. These drugs are also used as anxiety medications.

Examples of these antidepressant medications include citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil, Pexeva), and sertraline (Zoloft).

While these medications treat depression , it takes a significant amount of time before the drugs take effect. These antidepressant medications also have adverse side effects.

People with depression often go to psychotherapy (talk therapy) and support groups. They employ self-help and self-management approaches to treat their major depressive disorder.

Meanwhile, some people take natural supplements, like St. John’s wort. This herb reduces levels of cortisol, a stress-related hormone. St. John’s wort also increases neurotransmitters ’ norepinephrine, dopamine, and serotonin levels (26 ) .

According to Harvard Medical School, however, using St. John’s wort is not as effective as prescription medications like antidepressants . The herb also causes similar side effects (27 ) .

When taken alongside antidepressants , St. John’s wort may cause serotonin syndrome. This potentially fatal disorder happens when excess serotonin builds up in the body.

Exercise is useful in alleviating several medical conditions, including depression. This activity gives the body feel-good chemicals called endorphins and aids in nerve cell growth in the hippocampus (28 ) .

According to a study, exercise increases BDNF levels in the brain, thereby contributing to the improvement of depression (29 ) .

CBD may also be used in wellness practices, such as aromatherapy and massage. The infusion of CBD hemp extract and essential oils is found to have therapeutic benefits.

According to a study, using essential oils in massages helps reduce anxiety and depression symptoms, relieve pain and stress, and improve sleep (30 ) .

How to Use CBD Oil for Depression

One may take CBD oil using various methods, depending on which form would best suit the patient’s lifestyle.

CBD comes in different formulations, such as oils, tinctures (drops), gummies , capsules sprays, soft gels, or capsules.

These products can be taken sublingually (under the tongue), swallowed, added to food or beverages, vaped, or applied to the skin.

Tinctures may be taken sublingually using the dropper. Let the oil sit for 60 seconds to a minute and a half before swallowing.

CBD tinctures allow patients to adjust the dosage of the product quickly.

Meanwhile, CBD gummies and capsules provide a fixed dose of CBD . One can quickly ingest these CBD products and conveniently bring them anywhere.

With the ingestion method, CBD passes through the digestive tract, and the liver metabolizes its compounds before it reaches the bloodstream.

CBD oils can also be used during massages. Some CBD products are infused with essential oils that could be therapeutic, especially to patients who need to be relieved of stress.

CBD is also available in topical forms like creams and lotions. Topical CBD products are usually used for pain and inflammation management but seldom for treating depression.

Topical CBD has limited absorption. It is best to purchase products that indicate the use of nanotechnology, encapsulation, or CBD micellization because the CBD can be transmitted through dermal layers instead of only staying on the skin.

Some people also prefer taking their CBD in vape form. It is a popular method because users ingest the substance instantly, thereby giving the quickest results.

A 2020 study noted that the bioavailability of CBD is higher when it is inhaled (11% to 43%) than when it is orally ingested (11% to 13%) (31 ) .

Though the effects are instantaneous because CBD enters the bloodstream via the lungs and not the digestive system, vaping can lead to throat irritation or coughing (32 ) .

Before deciding to inhale CBD via vape pens, it is recommended to proceed with caution. Studies have shown that lung injuries and diseases are associated with vaping (33 ) .

There are three types of CBD oils patients with depression can choose from, full-spectrum CBD oil , broad-spectrum , and isolates.

Full-spectrum CBD oil utilizes all the components of a cannabis plant , including trace amounts of THC , terpenes , flavonoids, fatty acids, and essential oils.

However, THC may cause psychoactive effects in people and can be detected via drug tests.

For those who want to avoid these risks, using broad-spectrum CBD may prove useful. Broad-spectrum CBD oils contain all the components of full-spectrum oils without the THC .

Those who want to use CBD in its purest form or are allergic to other hemp plant components may purchase CBD isolates. They are pure CBD, as they only have isolated cannabidiol .

Buying CBD Legally

Although CBD is readily accessible in most parts of the United States, state laws may vary. Under the Farm Bill of 2018, hemp-derived CBD products with less than 0.3% THC are federally legal (34 ) .

CBD products are available at local dispensaries and health shops. Some states may require citizens to present a prescription or medical marijuana card before buying CBD-rich oils with more than 0.3% THC (35 ) .

According to the Anxiety and Depression Association of America (ADAA), CBD’s pricing regulations only apply to products approved by the Food and Drug Administration ( FDA ) (36 ) .

The vast majority of CBD products can also be purchased online. It is recommended to buy directly from the CBD brand’s official website.

Consumers should choose CBD products that have undergone lab testing. Third-party lab reports indicate the total amount of cannabinoids and absence of contaminants, including pesticides, bacteria, and heavy metals.

CBD Risks and Safety Considerations

According to the World Health Organization (WHO), CBD “is generally well-tolerated with a good safety profile (37 ) . ”

However, the side effects of CBD may include dry mouth, nausea, fatigue, drowsiness, loss of appetite and gastrointestinal problems, diarrhea, changes in alertness and mood, and liver damage (38 ) .

The CYP450 liver enzymes are responsible for breaking down several phytocannabinoids, including CBD (39 ) . Thus, it is not recommended to take CBD alongside medications with a “grapefruit warning (40 ) .”

CBD in high doses may also interact with other medications, such as antidepressants , immune suppressors, and blood thinners, and raise their levels in one’s system (41 ) .

Another significant safety concern is CBD being primarily marketed and sold as a supplement and not a medication. The US FDA currently does not regulate the purity and safety of dietary supplements (42 ) .

The FDA has approved only one CBD product for the treatment of epilepsy , Epidiolex (43 ) . Further investigation and clinical trials are still needed to prove that CBD is a safe and effective treatment for various conditions.

For now, the FDA advises people not to depend solely on CBD as an alternative to conventional healthcare (44 ) .

Understanding Anxiety & Depression

Anxiety and depression are detrimental to those who have them. These disorders significantly affect not only their health and well-being but also their social life and productivity.

These disorders are closely linked, although they are still different from each other. Depression is a more severe condition, while anxiety disorders could also trigger depression.

The US Department of Health & Human Services lists different types of anxiety disorders (45 ) :

  • Generalizedanxiety disorder(GAD) – GAD is characterized by exaggerated worry, chronic anxiety, and tension.
  • Panic disorder (PD) – PD is described by unexpected and repeated episodes of intense fear and panic attacks .
  • Post-traumatic stress disorder(PTSD) – PTSD may develop after exposure to a terrifying ordeal or traumatic events.
  • Social anxiety disorder(SAD) – SAD is characterized by excessive self-consciousness and overwhelming anxiety in everyday social situations .
  • Obsessive-compulsive disorder (OCD) – OCD is characterized by repetitive behaviors or compulsion and recurrent, unwanted thoughts or obsessions.
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These anxiety disorders may have different treatments. However, these disorders generally share the same symptoms, like restlessness, a feeling of dread or being “on-edge,” irritability, and difficulty concentrating and sleeping (46 ) .

Although the causes of anxiety vary, it is usually caused by biological factors, like genetics or chronic physical ailments and injuries.

Psychological or social factors may also contribute to anxiety. Some factors include experiences of poverty, childhood trauma, employment status, living or work environments, and family and personal relationships.

Meanwhile, depression could vary in people, from mild to severe. The symptoms are also different, but depressed people generally feel an encompassing sadness or hopelessness (47 ) .

Although depression and anxiety share similar causes, depression is a more complicated condition. Sudden life-changing events can also cause it .

These events may include pregnancies, life-threatening diseases like cancer, heart disease, chronic pain , and diabetes.

Conclusion

In recent years, several studies showed the health benefits of CBD in managing the symptoms of anxiety and depression. However, research on whether CBD alone can suffice in treating the said psychiatric disorders is still lacking.

CBD has anxiolytic , antipsychotic, and antidepressant properties. It activates 5-HT1A receptors , resulting in the reduction of depression.

CBD may increase brain-derived neurotrophic factor, which is low in depressed animals and humans.

Part of CBD’s antidepressant properties is its ability to facilitate the formation of neurons in the hippocampus . These properties of CBD may explain its positive effects on attenuating anxiety, psychotic, and depressive behaviors.

CBD may help improve sleep, reduce stress, enhance cognitive function, and stabilize mood, thereby making it useful in managing symptoms of depression .

Despite these developments, more research still needs to be done. However, it should be recognized that CBD has much potential in treating depression, especially since it has minimal side effects compared to SSRIs.

Before using CBD oil for anxiety and depression, it is best to consult with a medical professional.

4 Potential Ways CBD Can Improve Your Wellness

Cannabidiol (CBD) is one of the potent phytocannabinoids found in cannabis, accounting for more than 40% of the cannabis plant’s extract. It’s also one of the many cannabidiol receptor ligands (this means they interact with the brain receptor only).

CBD was initially developed as a possible replacement for the psychoactive substance THC (tetrahydrocannabinol), which is the main ingredient in pot. But CBD’s effects were investigated separately for many years before it was finally accepted as a potentially useful medical product.

You may have heard many comparisons between CBD and marijuana. But unlike THC, CBD doesn’t produce a ‘high,’ or intoxication, the way other THC-like chemicals do. Instead, it causes a relaxation of the blood vessels and brain, relieving muscle spasms and reducing anxiety, even to the point of improving moods. Also, compared to other pharmaceutical medications, CBD doesn’t cause serious side effects, like addiction or dependency.

The most common form of CBD is found in the oil extract of the cannabis plant, and CBD oil has been shown to effectively reduce the symptoms of different health ailments. In today’s world, we’ve heard about many different illnesses and diseases, like anxiety and depression, to the point that it’s really hard to believe that there could be an herb that would help alleviate the effects of such things, as well as improve a person’s quality of sleep.

But in what other ways can CBD improve your health?

1. Relief from Anxiety and Depression

There have been numerous studies done about CBD and its positive effects on your health. One of the most common ailments that are helped by CBD is anxiety.

In today’s society, anxiety and depression are two of the most common ailments that people suffer from. How can CBD help with depression and anxiety?

  • Various studies suggest that CBD may help reduce the symptoms of depression or anxiety in people who are currently taking medications for that condition. One of the most exciting benefits of CBD is the anti-psychotic and anti-anxiety effects it has on people. This is because CBD is very powerful in reducing the activity of certain enzymes that produce feelings of stress and anxiety. CBD has also been shown to improve mood and concentration.
  • The ingredient in cannabis is considered a safe alternative to prescription medication for depression or anxiety because it doesn’t cause the same side effects or complications. By calming the body and mind with little to no side effects, the levels of negative or anxious feelings are alleviated or minimized.
  • Unlike THC, which stays in the system throughout use and produces psychoactive effects, CBD is a non-psychotic, or mind-independent, substance.

2. Alleviate Pain and Inflammation

When a person is in pain, they tend to turn to their pain relief mechanism, which is to either get up and move around to alleviate the pain or to take a break and rest the affected area. Some take over-the-counter pain medications or ask for a prescription drug from their physician. But what many people don’t realize is that the powerful pain-relieving effect of CBD comes from the way the drug stimulates the body’s natural pain relief mechanism. Hence, CBD works by blocking the pain receptors, resulting in less pain and discomfort. This is why many people turn to their CBD subscription for natural relief from pain.

Another very interesting aspect of CBD is that it works extremely well as an anti-inflammatory. Endocannabinoids are lipids, fats, and protein fragments that are secreted by cells within the body. These chains link to different parts of the body and mediate a range of activities, including the natural anti-inflammatory actions of the two main active compounds in CBD oil.

CBD may offer people not only a more natural form of treatment for certain forms of arthritis but also a way of avoiding the common side-effects of prescription pain-killers, such as aspirin and ibuprofen. The benefits of CBD also extend to the circulatory system and the improvement of muscle tone and range of motion in people suffering from muscular arthritis.

3. Reduce Cancer-Related Symptoms and Side Effects

Recent studies are trying to prove that CBD can help lessen the symptoms of chronic pain associated with certain forms of cancer. In some experiments, test subjects who were prescribed CBD did report less severe physical side effects than those given placebos.

CBD may also help lessen the signs of the disease as well–it has shown the ability to reduce certain types of tumor cells from reproducing. While the National Cancer Institute (NCI) doesn’t endorse CBD or any cannabis-related medication as cancer treatment, they acknowledged CBD’s effect in moderating inflammation and the reproduction of cancer cells.

4. Improve Energy and Brain Functions

CBD may improve brain function by reducing the amount of dopamine in the brain. Dopamine is responsible for activating certain brain cells. Since CBD helps reduce the amount of dopamine in the body, brain cells will now work normally.

Aside from promoting a healthy nervous system and reducing anxiety and depression, CBD may also help increase your energy levels. This is due to CBD’s ability to increase blood flow throughout the body. Hence, when you take CBD, your mood may improve and your entire body will feel good.

CBD May Be Beneficial For Your Overall Wellness

In addition to the aforementioned potential health benefits of CBD for one’s wellness, CBD is also being investigated for its ability to help treat illnesses and prevent disorders of the entire human system.

While the body does contain some naturally occurring CBD, the synthetic CBD that we see on the pharmaceutical market isn’t one of them. Instead, what you most commonly find are CBD oil products or CBD capsules that are extracted from cannabis.

By taking an entire plant apart, researchers have been able to isolate and produce a wonder compound called CBD. This unique formulation provides the health benefits of CBD without the negative side effects that come from using marijuana or chemical drugs.

Takeaway

The bottom line is that CBD is great for your body. It may help you to feel better, reduce your chance of disease, improve your mood, help reduce anxiety and depression, and even boost your energy levels.

Best CBD Oils For Anxiety And Depression

As more people shun pharmaceutical medicine for anxiety and depression, we are witnessing a growing interest in alternative remedies such as CBD oil.

But even as cannabidiol becomes a household name, millions of people are still in the dark when it comes to understanding what CBD oil is, and how it may be used to manage anxiety. So to kick things off, let’s look at what anxiety is, and what CBD is, so as to gain a better understanding of how CBD oil can help manage this condition.

What is Anxiety?

Anxiety is a state in which an individual becomes extremely sensitive to internal or external stimuli, either because of a spike in stress hormones or because of an apparent threat. Under normal circumstances, this reactive state can help to keep you safe when threats emerge, but what makes anxiety unique is the fact that an individual maintains this state indefinitely, while constantly experiencing the effects of stress hormones.

As many as a thirds of the U.S. population experience anxiety regularly, and although most of these people have learned to live with it, a large number still find it difficult to go about their day-to-day life due to spikes in anxiety, with serious limitation to work and social life.

Why is Anxiety Dangerous?

As stated earlier, being anxious can be a useful evolutionary process because it keeps you alert through what’s known as the fight-or-flight response. But what about when there’s no immediate danger? What happens is, your body maintains those high levels of adrenaline and cortisol, causing massive shifts in your physiological processes.

How Could CBD Help With Depression?

What makes CBD unique, particularly in the treatment of anxiety, is the fact that it regulates the hormonal function and helps prevent any random spikes in adrenaline or cortisol. We mention cortisol mainly because of the destructive effects it has on normal health, especially in the muscles, where it causes muscle degeneration and increases the likelihood of acquiring injuries during training.

This ability to normalize hormone production extends beyond stress hormones to things like mood and depression. Although we don’t suggest that you stop taking medication for depression, there is a chance that using CBD oil can lead to increased feelings of wellness and positive vibes, following a boost in serotonin and the bliss hormone, anandamide.

How Does CBD Oil Work?

Cannabidiol works mainly through the endocrine system, and its counterpart, the Endocannabinoid System (ECS); a complex network of nerves, brain receptors, and endocannabinoids.

By targeting brain receptors responsible for mood (CB1), cannabidiol is able to increase the production of “feel good” hormones, which ultimately leads to higher energy levels and feelings of optimism and positivity.

Studies on CBD and other cannabinoids are still in the early stages, so there’s a lot that we still don’t know about how CBD oil impacts human health. Long-term studies are needed to determine how effective it is for treating conditions such as depression, and other conditions that require a combination of medicines and lifestyle changes.

How To Use CBD Oil For Treating Anxiety

The best way to maximize the effects of CBD oil is to start by gaining a better understanding of your anxiety and the situations that are likely to trigger the symptoms. In the case of social anxiety, you could start by taking a low dose of CBD oil an hour before leaving the house, and then gauge how you react when exposed to “known triggers”.

We don’t expect this to be a perfectly seamless experience, but the only way to discover CBD oil’s potential benefits is by experimenting with small doses of different CBD oils to see how your body responds.

Tips On Using CBD Oil For Anxiety

Take note of the THC content in your CBD oil, and whenever possible, avoid using products that have THC in excess of .3 per cent. This isn’t only to observe the legal aspect (because by federal law CBD oil shouldn’t contain more than 0.3% THC).

To help you identify the best products, keep this in mind when purchasing CBD oil:

  • CBD isolate contains cannabidiol alone, and none other compound found in hemp.
  • Broad-spectrum CBD oil contains most of the cannabinoids found in hemp and cannabis, except for THC.
  • Full-spectrum CBD oil is just marijuana converted into an oil form.

When taking CBD oil for anxiety, there’s a risk of exacerbating the symptoms if THC is present; because of its tendency to cause stress and paranoia. That being said, you may find relief from using products that contain multiple cannabinoids and terpenes (basically the collective compounds in cannabis) instead of just CBD alone.

This comes from what’s known as the “entourage effect”, a process in which using multiple cannabinoids leads to more holistic treatment than using a single cannabinoid.

Keep in mind that the human body naturally produces its own cannabinoids for managing physiological processes such sleep, hunger, mood, and so on. It is argued that using broad-spectrum CBD oil can lead to better results with conditions such as depression and anxiety because the body is better able to use the different compounds to generate relief.

Here are 5 decent CBD oils to use for anxiety:

  • RoyalCBD CBD Oil
  • NuLeaf Naturals CBD
  • Joy Organics CBD Tincture
  • HempBombs
  • CBDistillery

Bottom Line – Can CBD Help You?

The simple answer is yes. However, for CBD to be more effective, you may have to combine it with lifestyle changes that help reduce anxiety and depression.

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