Cannabidiol may interact with rheumatologic drugs
A number of medications commonly prescribed by rheumatologists may interact with cannabidiol oil, investigators at the Imperial College Healthcare NHS Trust, London, reported.
“Patients are increasingly requesting information concerning the safety of CBD oil,” Taryn Youngstein, MD, and associates said in letter to the editor in Rheumatology , but current guidelines on the use of medical cannabis do “not address the potential interactions between CBD oil and medicines frequently used in the rheumatology clinic.”
The most important potential CBD interaction, they suggested, may be with corticosteroids. Hydrocortisone and prednisolone both inhibit the cytochrome P450 enzyme CYP3A, but CBD is a potent inhibitor of CYP3A, so “concomitant use may decrease glucocorticoid clearance and increase risk of systemic [corticosteroid] side effects,” the investigators wrote.
CBD also is known to inhibit the cytochrome P450 isozymes CYP2C9, CYP2D6, CYP2C19, CYP3A4, and CYP1A2, which, alone or in combination, are involved in the metabolization of naproxen, tramadol, amitriptyline, and tofacitinib (Xeljanz), according to a literature search done via the college’s medicine information department that also used the British National Formulary and the Natural Medicines online interaction checker.
The Janus kinase inhibitor tofacitinib is included among the possible interactions, but the other Food and Drug Administration–approved JAK inhibitor, baricitinib (Olumiant), is primarily metabolized by the kidneys and should not have significant interaction with CBD, Dr. Youngstein and associates said. Most of the conventional synthetic and biologic disease-modifying antirheumatic drugs, including methotrexate, hydroxychloroquine, adalimumab (Humira), and abatacept (Orencia), also are expected to be relatively free from CBD interactions.
This first published report on interactions between CBD oil and common rheumatology medications “highlights the importance of taking comprehensive drug histories, by asking directly about drugs considered alternative medicines and food supplements,” they said.
The investigators declared no conflicts of interest, and there was no specific funding for the study.
How Hemp Seed Oil Can Help with Arthritis and Circulation
Many people falsely believe that arthritis is a normal part of aging . However, this can’t be any farther from the truth. And hemp seed oil can prevent the adverse effects of arthritis.
Some people simply dismiss arthritis , but if you know someone who is suffering from this painful disease, you may have an idea of how it can adversely affect one’s quality of life . Despite new methods to help treat arthritis, many people still prefer organic and natural alternatives to battle this excruciating and crippling disease.
If you have been researching arthritis remedies, you’re probably curious about what hemp seed oil can do for you. This is different from CBD oil and offers a wide array of benefits , which includes improving your circulation and making arthritis go away. Take a look at how hemp seed oil can help you take back control of your life.
What I s Hemp Seed Oil?
Even before the hype surrounding CBD and hemp oil started, individuals were already using hemp seeds without even being aware of its many benefits. Thanks to the surge in research concerning hemp and hemp products, we continue to learn about the wonders of hemp seed and hemp seed oil.
Hemp seed oil is extracted from hemp seeds. The use of hemp seed oil dates back to thousands of years when it was used for fuel, food, and medicine. I t was even used in the early 20th century to treat gonorrhea and was even included in the U.S. dispensary before it was banned due to its association with marijuana.
Hemp seed oil boasts the perfect balance of essential fatty acids , which are an important part of your diet to protect you against serious health conditions.
Hemp seed oil contains o mega – 3, and while this is also present in fish oil, research has found that fish oil does not give benefits to the heart. It even has side effects . This makes hemp oil a viable alternative and is around ten times more powerful than the widely popular fish oil.
Hemp s eed oil has an excellent composition , which is similar to the fatty acids in the skin. This makes it an effective topical treatment. Aside from its essential fatty acids , hemp seed oil is also rich in Vitamin E, which is comprised of molecules called tocotrienols and tocopherols. Compared to other edible oils, hemp seed oil has a richer concentration of tocopherols , which is vital in combating a wide range of degenerative ailments. It also contains antioxidants to counteract free radical damage.
Difference between hemp seed oil and CBD oil
Hemp seed oil is rich in CBD ( c annabidiol ) , which is a leading compound that treats and manages pain so much so that it is believed to be a game-changer in the medical industry. If you are still new to the world of hemp, you may interchange hemp seed oil with CBD oil. While these two share similar genetic compounds, these are different substances that offer their own set of benefits and uses.
H emp seed oil is extracted from the seed of the plant, and only industrial hemp can be used to make it. Meanwhile, CBD oil is made from the flowers, stems, and leaves of the hemp plant. CBD oil has an extraction method that guarantees a high amount of CBD content since it is the riches t cannabinoid in the plant. On the othe r hand, hemp seed oil contains only a small amount of CBD but features a full mixture of terpenes and its own cannabinoids that have its own benefits.
While CBD oil and hemp seed oil are both created from the same family as marijuana, both do not contain tetrahydrocannabinol ( THC ) , the psychoactive substance that gives people the psychoactive sensation of feeling “ high. ”
How Does It Work?
Hemp seed oil is very much like your favorite cocktail, but instead of containing alcohol, it contains a mixture of cannabinoids that react with the CB-1 receptors in your body. This affects your endocannabinoid system ( ECS ) . Your ECS plays an integral role in affect ing the nervous system, as well as all your regular functions such as sensory development, pain reception, and fluid production.
Hemp oil attaches itself to these receptors and prevents it from activating. Because of this, your pain is significantly reduced. Hemp seed oil is a champion in preventing and reducing inflammation, which can decrease the discomfort associated with arthritis. Since the cannabinoids present in the hemp seed oil are similar to the ones naturally produced in your body, it becomes even more effective.
How Can Help Seed Oil Help with Arthritis?
Arthritis refers to the inflammation of one or more joints. Symptoms may come and go , and it includes limited joint function, pain, swelling, and stiffness , which can range from mild, moderate, to severe. Many people also report that the pain gets worse over time. This makes many individuals unable to part icipate in daily activities or do simple tasks such as c limb ing stairs.
Arthritis has more than 100 types and related conditions that can affect people of all races, ages, and sexes. This fact makes it one of the leading causes of disability in the U . S ., affect ing over 300,000 children and 54 million adults. Osteoarthritis , which is its most common form, is usually managed through inflammatory medicines , which have serious side effects and can lead to tolerance. In serious cases, one may need to undergo joint replacement.
Arthritis is caused by bits of cartilage and bone which have degenerated. These rub together when you move or flex . When it touches nerve endings, it causes pain and creates more damage to the bone and cartilage. Because of this, arthritis becomes a vicious cycle that is hard to break free from.
If you’re suffering from arthritis or know someone who is, good news awaits you. There are many ways hemp seed oil can be beneficial to you, especially in dealing with pain. Hemp seed oil can relieve the ache of rheumatoid arthritis. Not only that, but it also aids in lowering the survival rate of cells that spread it. Certain doses can also cause the death of these dangerous cells.
Hemp Oil Lubricates Where You Need It
Think of your car engine. It would not function well without oil, right? The same can also be said for your bones. When you take hemp seed oil, it can act as the much-nee ded lubrication for your system , and because of its perfectly balanced profile and g amma- l inoleni c a cid content, it can improve your body’s ability to heal as well as boost your immunity.
The EFAs present in hemp seed oil are also a godsend for improving organ function, mental state, vitality, and facilitating cell growth. The amount of CBD present in the hemp seed oil reduces inflammation by preventing the formation of cytokine , which then reduces swelling, stiffness, and pain.
Hemp Seed Oil Does Wonders for Your Circulation
Aside from helping with arthritis, hemp seed oil is also well known for aiding with blood circulation. This oil can thin the blood , which promotes a healthy circulatory system. When your circulatio n is functioning well, you will also be lowering your blood pressure, which then decreases risk for heart issues and metabolic syndrome.
When the blood circulation in your scalp is improved, it can also enhance your hair texture, and give moisture to your hair. Therefore, you can say goodbye to hair breakage.
Other Uses for Hemp Seed Oil
Aside from relieving your arthritis and improving your circulation, there are many additional benefits you can get from using hemp seed oil.
First, you will enjoy healthier hormones thanks to its GLA content . This is an integral component for prostaglandins , which help with body temperature and inflammation. Once you supplement with hemp seed oil, you will increase your GLA , which can help with your skin allergies, stress, heart disease, and even obesity.
If you are suffering from digestion problems, you can also reach for your hemp seed oil. For those who want a solution, hemp seeds are the answer thanks to its rich fiber content that gives the gastrointestinal system material to keep things running smoothly.
Another potential benefit of hemp seed oil is that it might prevent cancer . You may not think about it much , but this illness affects you in one way or another, whether it’s you will undergo treatment, or a close friend or relative. Thankful ly, hemp seed oil provides hope.
Aside from this, hemp seed oil is also beneficial for the skin since it acts as an outstanding natural moisturizer. Unlike other oils, hemp seed oil does not feel oily and heavy. It can also be quickly absorbed by the skin and let you feel soft immediately. You may massage it to your skin, hair, and nails, fresh out of the shower.
Whether you prefer dietary or external application, using hemp seed oil is also a good strategy for combatting eczema and acne , which are caused by EFA imbalance. Not only that, but it also counteracts the effects of aging by improving the fat composition in the outer layer of the skin. This benefit will keep you looking young and fresh.
How to Use Hemp Seed Oil
Hemp oil is a natural, sustainable, safe, and practical alternative to prescription medication. Because of its low risk of side effects, you can use it in many ways. If you feel arthritis pain coming, it is recommended to be applied topically to affected areas to prevent the onset of any discomfort.
Aside from this, you may also incorporate it into your daily meals. Hemp seed oil has a pleasing nutty flavor , which makes it an amazing addition or base for dips and dressing s . You may even top your pizza with it instead of olive oil , or add it in your favorite desserts . Hemp can also complement the flavor of vegetables, rice, quinoa, and meats.
A d aily dose of hemp seed oil ingested orally comes with numer ous benefits. If you don’t want to incorporate it in your meals, you may simply put a few drops under your tongue. This method will allow it to enter your bloodstream faster. Now, all your skin and body supplements, as well as cooking oil can be in the same bottle. However, be careful of using it in cooking since it has a low smoke point.
Hemp Seed Oil Can Help You
Hemp seed oil remains an unbeatable all-around alternative to medicine that can be used even by vegans and vegetarians. At Hel p Me Hemp, our hemp seed oil has been organically farmed since 1998. With this experience comes a top-tier natural remedy that can improve your quality of life. When you get rid of arthritis and improve your circulation, you can spend more time doing what you love without worrying about unbearable pain ever again.