Orally consumed cannabinoids provide long-lasting relief of allodynia in a mouse model of chronic neuropathic pain
Chronic pain affects a significant percentage of the United States population, and available pain medications like opioids have drawbacks that make long-term use untenable. Cannabinoids show promise in the management of pain, but long-term treatment of pain with cannabinoids has been challenging to implement in preclinical models. We developed a voluntary, gelatin oral self-administration paradigm that allowed male and female mice to consume ∆ 9 -tetrahydrocannabinol, cannabidiol, or morphine ad libitum. Mice stably consumed these gelatins over 3 weeks, with detectable serum levels. Using a real-time gelatin measurement system, we observed that mice consumed gelatin throughout the light and dark cycles, with animals consuming less THC-gelatin than the other gelatin groups. Consumption of all three gelatins reduced measures of allodynia in a chronic, neuropathic sciatic nerve injury model, but tolerance to morphine developed after 1 week while THC or CBD reduced allodynia over three weeks. Hyperalgesia gradually developed after sciatic nerve injury, and by the last day of testing, THC significantly reduced hyperalgesia, with a trend effect of CBD, and no effect of morphine. Mouse vocalizations were recorded throughout the experiment, and mice showed a large increase in ultrasonic, broadband clicks after sciatic nerve injury, which was reversed by THC, CBD, and morphine. This study demonstrates that mice voluntarily consume both cannabinoids and opioids via gelatin, and that cannabinoids provide long-term relief of chronic pain states. In addition, ultrasonic clicks may objectively represent mouse pain status and could be integrated into future pain models.
Fig. 1. Mice stably consume cannabinoid and…
Fig. 1. Mice stably consume cannabinoid and opioid gelatin over 3 weeks.
Fig. 2. Microstructure of gelatin consumption.
Fig. 2. Microstructure of gelatin consumption.
Fig. 3. Cannabinoid consumption decreases measurements of…
Fig. 3. Cannabinoid consumption decreases measurements of neuropathic pain over 3 weeks.
Fig. 4. Measures of analgesia and body…
Fig. 4. Measures of analgesia and body temperature in neuropathic pain-naïve mice.
Best Advice To Pick The Best CBD Capsules For Blood Pressure | Cannabis Blog
CBD cream can be used every day with very few risks of side-effects beyond mild sedation and intensifying the effects of some medications. There is really nothing to lose by giving it a try and seeing if it helps you with your sciatica or numerous other ailments. Considering that anticonvulsant drugs are regularly given for the treatment of sciatica, the off-label use of prescription CBD as a substitute appears well-grounded. The FDA has legalized the first cannabis-derived CBD medication called Epidiolex as a more effective alternative to traditional epilepsy treatments.
These gummies are formulated to support recovery from exercise, sleep, and calm. Each gummy mixes a different measurement of CBD with a botanical blend or melatonin. When it comes to CBD for sciatica pain, these gummies may be a great supplement to help alleviate pain. The only drawback is that these gummies are not certified organic… yet. Charlotte’s Web says that they practice as such in hopes of becoming organically certified in the future.
In this case, the sciatic nerve is signaling to the brain that other tissues nearby are damaged and releasing inflammatory substances that trigger the nerve. Opioids are synthesized to replicate the compounds in natural Opium plants. But now, you can use CBD cream for sciatic nerve pain without the toxic side-effects. As seen above, CBD may be able to provide relief to those suffering from the symptoms of sciatica.
So, before we can acknowledge if CBD oil for sciatica can calm some of the pain we’ll need to understand what happens. First you’ll need to always make sure you’re consulting with a professional physician that has diagnosed your symptoms. This is the best way to ensure you’re making the best decisions for your body.
CBD can be used to calm a variety of health issues including anxiety, insomnia, chronic pain, and childhood epilepsy syndromes. Many prescription drugs used to treat chronic pain are associated with harmful or addictive side effects. That’s why there have been studies testing therapeutic approaches, such as CBD, to alleviate chronic or inflammatory pain. The tide is turning in favor of widespread cannabis legalization as patients start to see the many benefits of substances that were once criminalized.
- Unless otherwise noted, they’re all made with U.S.-grown hemp and have a certificate of analysis proving each contains 0.3 percent or less THC.
- The cannabis compound is in everything from skin creams to your gummies to oils.
- Also important, the CBD products included here stick to the law of the land.
- One 2018 review of organic cbd gummies studies between 1975 and 2018 concluded that CBD helped ease chronic pain for a number of conditions — fibromyalgia and neuropathic pain, to name a few.
Mixing CBD with alcohol somehow reduces the amount of alcohol in the bloodstream but can magnify the effects of alcohol. While it is thought to protect the organs and nerves from damage, people who take CBD should take caution and allow more time before they try to operate a motor vehicle, even if they only had one drink. Unlike other types of pain, sciatic nerve pain usually manifests as neuropathic and nociceptive pain. Neuropathic pain is a neurological problem caused by damaged nerves that become dysfunctional. Nociceptive pain is the pain that patients suffer in response to an injury.
If you’re curious about finding the right CBD for sciatica pain or inflammation, it really boils down to your personal preference. You may prefer CBD that tastes good, such as gummies or flavored mints. Or maybe you’d rather take CBD that you can swallow in a capsule. And we’re committed to showing you those options so you can find the best CBD for sciatica that makes the most sense for you.
CBD oil for Sciatica may be an option for you if you’re looking for alternative options from pain killers. Cannabis use and supporting the Endocannabinoid System for pain relief is a two prong approach to deal with inflammation. Smoking Cannabis provides little relief for acute pain associated with my sciatica, but it does help with sleep.
If it’s inflammation related, more than likely is, then CBD will help relieve the pain. CBD makes a world of difference for my sciatic pain because I had a microdiscectomy on my L5-S1 this year. The sciatic runs through those vertebrae, and any inflammation in that area causes pain. Charlotte’s Web boasts that it uses the world’s most trusted hemp extract.
Ways Medical Cannabis Can Help Sciatica Pain
Nearly 65 million Americans report dealing with some back pain at one point or another. Eight percent of those people — around 16 million people in total — say their back pain is persistent or even chronic. It’s also worth noting that back pain is the sixth most costly health condition in the U.S., costing people nearly $12 billion per year!
One of the most painful conditions that may lead to back pain is sciatica. According to the Mayo Clinic, sciatica is a condition that frequently occurs due to bone spurs or herniated discs putting pressure on the sciatic nerve. It can affect the lower back, hips, and legs, causing severe pain. This pain leads to millions of American workers missing time at their jobs, causes feelings of sadness, worthlessness, and hopelessness, and leads to limitations in social, recreational, and family activities in the process.
For too many Americans, the traditional option for treating this pain often means they’re forced to resort to addictive, addictive, and harmful opioids for relief. But those synthetic opioids aren’t the only option, and research shows that cannabis has a role to play in treating and managing sciatica symptoms and relieving back pain in general.
This article will break down why medical cannabis is an effective treatment option for managing sciatica symptoms, why it’s so effective in managing pain, and how it can help sciatica pain.
Location of piriformis syndrome within the body. Piriformis syndrome can cause sciatic pain. Patrick J. Lynch & KDS4444. Source: Wikimedia Commons & Wikipedia. CC BY-SA 2.5.
How Medical Cannabis Can Help Treat Sciatica
Over the past two decades or so, we’ve been lucky enough to see enormous strides made in the field of research when it comes to the impact of medical cannabis on patients. Let’s break down what the research says about how medical cannabis can help deal with the lingering effects of sciatica.
The effect on the endocannabinoid system
One example is the further understanding of how the body’s endocannabinoid system works. We’ve seen promising research come out in the past few years about the impact the cannabinoid system has on sleep, pain, mood, and appetite, along with a deeper understanding of the role it might play in illnesses like neuropathy. While we certainly still have more to learn about it, researchers have discovered enough about it to link the effects of cannabis use to it.
Ingesting additional cannabinoids that your body produces naturally has been shown to impact those suffering from sciatica profoundly. One study found that using Sativex, a 1:1 CBD/THC mix, was more effective than a placebo in treating and reducing sciatica pain. Another study showed that cannabis helps reduce pain and significantly decreases the use of prescription opioid medications, which are sometimes used for pain caused by sciatica.
While there’s still much to learn about how cannabis interacts with our body, we know that consuming cannabinoids intensifies the balancing "feature" of the endocannabinoid system, which in turn lessens the painful sensations that we feel throughout our nervous system.
The Role of THC
We’ve covered the impact of tetrahydrocannabinol (THC) on treating pain, managing stress and anxiety, and improving the overall quality of life here at Leafwell often. Still, THC itself can be a powerful treatment tool for sciatica specifically.
One of the only official studies done so far on the role THC has explicitly to play in treating radicular pain, which radiates from the spine and flows down into the legs, showed that THC significantly diminished pain levels compared to the placebo.
Participants were asked to rate their pain levels on a numbered scale (0-100). Before taking anything, the participants rated their pain level 53 on average. After the placebo, it was 43 on average, and after the THC treatment, it was 35. That’s a significant impact when treating pain, especially something as potentially debilitating as back pain can be.
The Role of CBD
While we have yet to see conclusive studies published on the direct links between cannabidiol (CBD) and sciatica pain, we have plenty of clinical research on the overall positive effects of CBD on a wide variety of related conditions.
For example, some studies have shown that CBD helps with neuropathic pain in conditions like diabetes. We have also seen some research showing that CBD helps to reduce pain in general, and other studies show CBD helps reduce pain and inflammation without causing a tolerance build-up.
It’s also worth noting that CBD has a profound effect on reducing stress, anxiety, promoting restful sleep, and easing symptoms of depression in those who use it. Almost three-quarters, or 72 percent, of those with back pain report that such feelings have interfered with their life, compared to 61 percent of those without back pain. People with chronic back pain report significant levels of psychological distress, including feelings of anger and depression. In contrast, people who have suffered an acute episode of back pain are less likely to report these feelings. If CBD can ease those symptoms even a little bit, it would significantly affect the overall quality of life for those suffering from sciatica.
If you suffer from back pain or sciatica, you may be eligible for a medical marijuana certification. Chronic pain is the most common qualifying condition in the U.SS. Find out if you’re eligible today.
Article written by
Joe Evans Content Writer
Joe Evans is a journalist, writer, editor and contributor for Leafwell. He has, to date, more than 5,000 articles published online under his byline on topics like cannabis, local and National news, politics, automotive news, sports, pop culture and even a cult.
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