Comparison of Cannabinoids to Placebo in Management of TMJ Pain and Myofascial Pain in the TMJ Region
The aim of this study is to determine whether the cannabinoids taken orally in the form of cannabidiol (CBD oil-a major non-psychoactive component of marijuana) or placebo (hemp oil) will provide pain relief and improved jaw function in those who suffer from either myofascial pain disorder and/or arthralgia of the temporomandibular region. The study hypothesis is that CBD oil is superior to placebo.
- Other: CBD Oil
- Other: Hemp Oil
Arms and Interventions
CBD PURE CBD OIL 20mg/1ml concentration – 1 ml (20mg) qd PO, hold under tongue for 1 minute and swallow daily
CBD PURE Hemp Oil- 1 ml qd PO, hold under tongue for 1 minute and swallow daily
Primary Outcome Measures
- Change in baseline in pain, as measured by the Visual Analog Scale (VAS) [Baseline, 3 weeks, 7 weeks, and 11 weeks]
Scores are measured from 1-100mm VAS. The VAS ranges from 0 to 100 with O indicating no pain and higher scores indicating a greater pain.
Secondary Outcome Measures
- Change in jaw functional limitations as measured by the jaw functional limitation scale. [Baseline, 3 weeks, 7 weeks, and 11 weeks]
Scores are measured from 5 (lowest) to 25 (highest). Higher scores reflect better jaw function.
Men and women 18-70 years of age
Ability to give informed consent
Arthralgia of the temporomandibular joint as defined according to the RDC/TMD criteria (see below chart) and/or Myofascial pain of masticatory muscles as defined according to the RDC/TMD criteria (see below chart)
Baseline pain must be greater than 3/10 as self-reported on the VAS
Allergy to study drug
Traumatic injury of masticatory muscles or temporomandibular joint within last 12 months
How to use cbd oil for tmj
The purpose of this study is to determine if the consumption of CBD (cannabidiol) oil is superior to a placebo (hemp oil) on the patient’s jaw pain to determine which is better. CBD oil is the major non-psychoactive component of marijuana extracted from the hemp plant. Hemp oil is also an extract from the hemp plant; however, it only contains trace amounts of CBD. Myofascial pain involves pain of muscle origin localized to certain muscle groups that is worsened with movement or touch. Arthralgia is joint pain. The temporomandibular region are the joints that connect the lower jaw to the skull.
The aim of this study is to compare the effect (good and bad) of the CBD oil with a placebo (hemp oil) for the intervention of jaw pain to see which is better. We are doing this study because currently there is no single intervention for jaw pain that has been found to be significantly superior to another. Typically, conservative interventions such as the use of oral appliances, non-steroidal anti-inflammatory medications, muscle relaxants, physiotherapy, behavioral therapy and acupuncture have been used, but some of these therapies present with many side effects with long-term use and may not be an appropriate means of intervention for certain groups of people. We would like to test the effectiveness of CBD to treat jaw pain because it could be used in place of these other interventions.