How CBD Helps With Stomach Ulcers?
CBD oil is gaining popularity as a pain-relieving option. Can CBD oil truly assist with the indications and symptoms of this condition, despite the fact that research on CBD and other cannabinoids as an effective treatment for different digestive issues is limited?
Stomach ulcers can cause severe pain and sometimes bleeding in the belly, but they can be treated, especially in the early stages. Many people who are suffering from gastrointestinal issues are turning to CBD for help…
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What Are Stomach Ulcers?
Stomach ulcers (also known as peptic ulcers or gastric ulcers) arise when stomach acid destroys the digestive tract’s lining. When the stomach’s mucus layer wears away and stops working properly, acid can damage the stomach tissue, resulting in an ulcer.
The esophagus and the duodenum, the top portion of the small intestine, are both susceptible to ulcers. Stomach ulcers are a common ailment that can strike anyone at any age. They are, however, more frequent in males and those over the age of 60.
On an empty stomach and at night, ulcer symptoms are typically severe. Symptoms of an ulcer include:
Upper abdominal discomfort or burning pain
- Loss of appetite and weight loss
- Stools in a dark black color
One of the following is nearly invariably the cause of stomach ulcers
- A stomach ulcer is caused by the bacteria Helicobacter pylori (H. pylori)
- By the sage of nonsteroidal anti-inflammatory medications (NSAIDs) such as aspirin, ibuprofen, or naproxen over an extended period of time
- Zollinger-Ellison syndrome is a rare disease that causes stomach and intestine ulcers by boosting the body’s acid production. This condition is thought to be responsible for fewer than 1% of all peptic ulcers.
How is Stomach Ulcer Diagnosed?
Your symptoms and the severity of your ulcer will determine your diagnosis and treatment options. Your doctor will examine your medical history, symptoms, and any prescription or over-the-counter drugs you’re taking to determine if you have a stomach ulcer.
Blood, stool, or breath tests may be done to rule out H. pylori infection. A breath test requires you to sip a transparent liquid and then breathe into a bag that is then sealed. If H. pylori are present, the carbon dioxide levels in the breath sample will be greater than normal.
Other tests and procedures used to diagnose stomach ulcers are discussed below:
A thick white liquid (barium) is swallowed, which covers your upper gastrointestinal system and allows your doctor to examine your stomach and small intestine on X-rays.
Endoscopy (EGD) is a procedure that involves inserting a thin, lighted tube via your mouth into your stomach and the first portion of your small intestine. This test is performed to check for ulcers, bleeding, and any abnormal tissue.
What Is CBD?
CBD, commonly known as cannabidiol, is one of several chemicals produced from the cannabis plant known as cannabinoids. While cannabis usage is frequently linked with getting high, the psychoactive effect is caused by THC, a distinct cannabinoid. CBD, on the other hand, does not cause euphoria. Instead, CBD offers a slew of potential advantages, one of which being the ability to treat ulcers. CBD may provide further digestive health advantages. It might be used to treat Crohn’s disease and IBS symptoms.
CBD For Stomach Ulcers
CBD has been shown to be effective in treating ulcer symptoms. CB1 receptor activation with cannabis reduces stomach acid production in people and experimental animals, according to studies.
As per studies, CBD helps in the reduction of the flow of gastric acid and improves blood flow to the stomach lining. Direct activation of CB1 receptors by cannabis significantly lowers both gastric acid production and gastric motor activity, as well as the development of lesions on the stomach lining, according to researchers in a 2016 study published in Current Neuropharmacology.
A study examined the impact of cannabinoids on the gastrointestinal tracts of mice, rats, guinea pigs, and humans.
According to research, CBD activates your CB1 receptor, which helps to reduce stomach acid production. As a result, CBD reduces gastric acid while also increasing blood supply to the stomach lining, both of which can help relieve or prevent ulcer formation.
Non-steroidal anti-inflammatory medicines (NSAIDs), such as ibuprofen or aspirin, can induce stomach or duodenal ulcers, according to the National Health Service (NHS) of the United Kingdom. This is especially true if these medications are taken for a long time or at high dosages. Meanwhile, CBD may aid in the treatment of stomach ulcers by providing excellent pain relief.
Nausea is the sensation or desire to vomit. Medication, chemotherapy, food poisoning, morning sickness, general anesthesia, and migraines are only a few of the causes. According to a review published in the journal Psychopharmacology, activating the CB1 receptor reduces vomiting.
CBD’s anti-nausea benefits may be due in part to its indirect stimulation of the 5-HT-1A autoreceptors in the brain stem’s “vomiting center” or “chemoreceptor trigger zone,” according to studies.
CBD oil is still undergoing several scientific and medical tests to establish its effectiveness in combating stomach ulcers; nevertheless, because CBD oil is a known pain reliever, it may be able to assist you to find relief from the pain produced by this condition. Your doctor will be able to tell you whether CBD interacts with any of your existing medicines and can help you figure out the best dosage for you. When using CBD, start with low to moderate dosages and gradually increase until you reach the desired outcomes.
The Cibadol range of CBD products includes CBD Muscle Relaxant (1800mg), CBG Tincture (900mg), CBN oil for Sleep (1050mg), CBN Tincture (300mg), and CBD Pet Tincture (1800mg), besides a host of others.
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Gastric ulcer: Can cannabis be helpful in gastric ulcers?
There are no clinical studies with cannabinoids in gastric ulcers. However, THC and other substances that bind to the cannabinoid-1-receptor (CB1 receptor agonists) inhibited the gastric acid production in humans and the formation of ulcers in animals.
The nervous system of the bowel of several species, including the mouse, rat, guinea pig and humans, contains cannabinoid CB1 receptors that depress motility of stomach and intestine. (. )
Gastric acid secretion is also inhibited in response to CB1 receptor activation, although the detailed underlying mechanism has yet to be elucidated. Cannabinoid receptor agonists delay gastric emptying in humans as well as in rodents and probably also inhibit human gastric acid secretion. (. )
The extent to which the effects on gastrointestinal function of cannabinoid receptor agonists or antagonists/inverse agonists can be exploited therapeutically has yet to be investigated as has the extent to which these drugs can provoke unwanted effects in the gastrointestinal tract when used for other therapeutic purposes.
Modified according to: Pertwee RG. Cannabinoids and the gastrointestinal tract. Gut 2001;48(6):859-867.
Adami et al.
In anaesthetized rats the non selective CB-receptor agonist WIN 55,212-2 and the selective CB(1)-receptor agonist HU-210 dose-dependently decreased the acid secretion. (. ) Our results indicate that the antisecretory effects of cannabinoids on the rat stomach are mediated by suppression of the activity of the vagus nerve on the stomach through activation of CB1 receptors.
Modified according to: Adami M, et al. Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach. Br J Pharmacol 2002;135(7):1598-1606.
Sofia et al.
Delta-9-tetrahydrocannabinol (THC) inhibited ulcer formation in the rat. However, this antiulcer activity of THC was substantially less than for tridihexethyl chloride.
Modified according to: Sofia RD, et al. Evaluation of antiulcer activity of delta9-tetrahydrocannabinol in the Shay rat test. Pharmacology 1978;17(3):173-177.
Nalin et al.
In 90 volunteers participating in a vaccine-development programme consumption of beer more than 3 days a week was linked with high stomach acid output, and smoking of cannabis greater than 2 days a week was linked with low acid output.
Source: Nalin DR, et al. Cannabis, hypochlorhydria, and cholera. Lancet 1978;2(8095):859-862.