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31 Benefits and Uses of CBD Oil

Here are 31 proven health benefits and uses of CBD oil that are all backed by scientific studies. Hemp-derived Cannabidiol (CBD) has been trending lately as an agent with many health benefits. CBD comes from the Cannabis Sativa plant, and is used in many forms, including CBD oil tinctures, gummies, creams, and more. Each form with their own unique benefits.

These products are currently being taken by millions of people to supposedly help different symptoms, with great success. However, many benefits of CBD oil are overblown, misinterpreted, or preliminary. This CBD oil benefits guide is the most comprehensive list of the benefits of CBD oil to date. All backed by real studies and scientific research. For 15 Severe CBD Oil Side Effects list click here .

Before we get into the benefits, let’s go over how CBD works in general. In summary. When CBD is absorbed by the body it flows through your bloodstream and ends up in the brain where it binds to neurotransmitters and neuroreceptors called endocannabinoids.

Endocannabinoids and metabolizing enzymes are a part of our Endocannabinoid System (ECS) that regulates factors such as pain, anxiety, sleep and more. When CBD reaches these receptors, it can tell your brain cells to “relax, eat, sleep, forget and protect.” Helping relieve many symptoms.

Here is a Complete List of CBD Oil Benefits:

1. May Relieve Pains: Chronic Pain

CBD products have been found help relieve or reduce pains ranging from minor to severe relief based on the strength and concentration of the CBD product used.

Studies of CBD oil ingestion suggest that CBD is beneficial for pain relief.

One study on pain relief from incision cuts found that rats had less pain specifically caused by cuts or incisions after using CBD. Rats that were given CBD oil in a non-rewarding way, wanted to take more CBD oil as a reward, presuming that rats wanted more because “ of pain relief or reduction of pain aversiveness.” This study concluded that the effects of CBD could play a role in pain relief.

A study from 2012 analyzed the effects of CBD on chronic pain, or more specifically neuropathic and spinal pain stated “we report that system and intrathecal [into the spinal cord] administration of cannabidiol (CBD). significantly suppress chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance [increased tolerance against CBD] in rodents.”

What this means is that rodents were able to receive pain relief without building an increased tolerance against CBD, therefore each daily dose did not become less effective overtime. Which is good news for human consumption. However, human studies need to be done to make any conclusion. Based off this evidence, the benefits guide goes as follows.

2. May Reduce Anxiety and Social Anxiety Disorder (SAD)

A study published in 2010 tried to study the difference in effects of CBD and a placebo for Social Anxiety Disorder using neuroimaging to analyze differences in blood flow in the brain. With a daily oral dose of 400mg of CBD oil, the study found that CBD had a significant effect on subjective anxiety. The study concludes and suggests that CBD does have an effect on SAD and a reduction in anxiety.

Another study tested subjects who were given a task of a “Simulated Public Speaking” test to test if CBD helps with Public Speaking anxiety. The study gave the subjects 300mg of CBD, which was tested against four other “drugs” in a double-blind test.

After the testing was complete, they analyzed the subjects and found that CBD “ decreased anxiety after the SPS test.” This means that the CBD helped reduce anxiety caused by the simulated public speaking test. The test concludes suggesting that CBD has anxiolytic (anxiety reducing) properties in human volunteers submitted to a stressful situation.

3. May Help Reduce Fear Reaction or Effects

A study (Musty 2005) on CBD for fear was tested on rats, and found that 40mg of CBD helped rats in fear. CBD may have pharmacological effects an antagonist of the CB1 receptor, which affects fear too. Noting that context of the type of stress, anxiety and fear has an effect on the anti-anxiety effect.

Another study (Front Pharmacol. 2016) on fear treatment using CBD found four ways that CBD helps fear.

  • Cannabidiol (CBD) decreases fear expression acutely

This is how, or the ways in which people show their fear. The study found no dosage dependency for effects.

  • Cannabidiol disrupts memory reconsolidation (re-remembered), leading to sustained fear attenuation (reduction) upon memory retrieval.

This aid in fear also may help PTSD as well. When traumatic memories are remembered, they are stored as “important” by the brain. By this statement, CBD could disrupt this process, and eventually lead to less severe negative memories being processed.

  • Cannabidiol enhances extinction, the psychological process by which exposure therapy inhibits learned fear.

This related to helping fight fear, through exposure. In which CBD could help improve the therapeutic healing process.

  • Auditory fear expression is also reduced acutely by cannabidiol.

Meaning CBD has a possibility to reduce fear caused by sounds and noises. The study found that the dosage of CBD for Auditory fear had to be a lot more than contextual fear.

The study notes that CBD is tested and has shown benefits for contextual fears (context matters). As well as states that other evidence indicates how CBD “modulates fundamental neurobiological processes” with Pavlovian fear conditioning, which is learning the different environments and stimuli that are related to threats, and therefore helping survival during fearful events.

The study concluded that CBD has found benefits for regulating “learned fear” which includes PTSD, in which something feels dangerous because it was trained to be felt dangerous, although the encounter is not exactly possible. Such as a fear of Great White sharks at the beach without ever actually interacting or being threatened by one. CBD is suggested to reduce this fear until it is no longer present by “ regulating learned fear by dampening its expression, disrupting its reconsolidation, and facilitating its extinction.”

4. May Reduce Depression & Increase Mood

By virtue of being being to inhibit anxiety, CBD has been also found to help depression by relieving depression-like symptoms.

A study ( Epub 2015) on the specific effects of CBD on depression found results that “CBD exerts fast and maintained antidepressant-like effects as evidenced by the reversal of the OBX-induced hyperactivity and anhedonia.”

Anhedonic symptoms include a lack of enjoyment of things that wasn’t caused by any type of physiological disease. Examples of this would include financial problems, overworking, or family issues.

An example of hyperactivity is ADHD. Where based off the results, CBD may be able to help people with ADHD. This is also a stretch, and is not backed up by any substantial evidence.

The CBD helps depression by enhancing the signals of serotonin and glutamate a specific receptor mechanism (5-HT1A).

5. May Reduce Stress

Also in similar terms as CBD helping depression, there is plenty of evidence suggesting that CBD can be great for stress as well.

CBD for stress works the same way as it does for anxiety, depression, mood and other neuro-related effects by affected the Cannabinoid receptors in our brain. Specifically the CB1 and CB2 receptors. Through these receptors, CBD was found to help decrease traumatic and chronic stress in both human and animal studies.

Through research of anxiety, it was found that CBD helps post-event for anxiety. In that note, CBD would help after stress-inducing situations occur. Such as car accidents, job firings, or tragic events. However, more research still needs to be conducted before any definitive conclusion can be made for stress specifically.

An additional study from May 2019 of 42 heroin addicted adults found that 800mg of CBD lowered stress hormone, heart rate, and cortisol levels compared to adults who were not taking CBD.

6. May Help Sleep Insomnia

CBD has shown to hemp improve the symptoms of insomnia (Russo et all 2007).

A brand new study from January of 2019 studied 75 subjects who stated issues with sleep insomnia or anxiety. Those with anxiety were given a 50mg-75mg dosage of CBD every night after dinner and before bed for over a month. The study found that 66% of these people found that CBD helped their sleep improved over that month.

The CBD was given to them in capsule form. Sleep insomnia is one of the main proponents of using CBD, and there is decent evidence and studies showing CBD benefits for sleep.

7. May Work as an Antioxidant:

In combination with THC, CBD was found to have “neuroprotective antioxidant properties (Hampson et al 1998).

8. May Help Reduce Symptoms of PTSD

For a more in-depth view of how CBD can help PTSD as well as Veterans with anxiety, click here.

However, one study (Das et al. 2013) that was not included in that article was a human study that found that CBD only helped those who had recovered from PTSD naturally and took CBD consistently after. In other words, CBD only worked to help prevent future recurrences of PTSD after someone had stopped having visual memories with fear. Not before.

This study is not completely proven, but there are a few other cases that found a similar result.

The study concluded that CBD has the possibility to be a better treatment than current solutions available for PTSD and other phobias. Including benzodiazepines. While also having less side effects than antidepressants.

9. CBD May Help Fibromyalgia

The evidence that CBD helps fibromyalgia are limited and inconclusive. The only real evidence supporting this are customer reviews who have found benefits for fibromyalgia, and also supporting evidence of inflammation and pain relief in general.

By helping decrease inflammation, CBD is likely to also help issues caused by fibromyalgia.

One study from 2006 did find evidence for a theory that a lack of overall endocannabinoids in the brain is possible to cause issues such as fibromyalgia, migraines, irritable bowel and other “treatment-resistant” symptoms. These neurotransmitter deficiencies are able to possibly elevate these symptoms.

In that case, CBD would restore these deficiencies as CBD is binds those receptors in the brain. The article suggests that Cannabis is a possible solution for Fibromyalgia, as well as migraines.

10. May Help Relieve Cancer Pains & Cancer-Related Symptoms

A study of 177 people that had intractable (chronic with no known cure) pain caused by cancers that are not responsive to opiates showed that Sativex produced statistically significant evidence for relieving the pain while an almost pure THC extraction did not show any significant pain relief. This evidence proposes that CBD may have been valuable for providing pain relief for cancer related pain.

Additionally, in two other studies from 2005 and 2006 ((Kogan; Ligresti et al) CBD and THC combined was able to destroy the growth of malignant (deadly) cells as well as prevent cancer-created cells from developing.

In 2007, a drug that is almost equal THC to CBD in ratio called Sativex was approved as a treatment for intractable cancer pain. Intractable pains are constant pains that have not been found to be cured by anything. CBD attaches to receptors in the ECS system, that controls the central nervous system such as the brain, as well as the peripheral nervous system. Initial research has found that this binding has found relief benefits for this type of cancer pain. The evidence is still minor, but there these studies provide optimism for how CBD may help cancer.

11. May Help with Yoga, Meditation, Fitness, & Sports

Because of the benefits of CBD found for pain relief, inflammation, as well as anxiety and sleep insomnia, there is a large sector of athletes and amateurs alike who have turned to CBD relief to help with their symptoms. Athletes in all facets of sports have started using CBD to help with post workout and recovery training.

Especially with injuries as shown by benefits of inflammation and pain relief. Professionals and amateur athletes are using CBD to get ahead. And it’s working. As well, CBD and Yoga is becoming very popular because of their similar functionality and usefulness for those who want to relax and clear their minds.

12. May Give Relief From Nausea and Vomiting

From another study in 2005 (Pertwee), it was found that CBD in addition to CBD can have effects that relieve nausea and vomiting.

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13. May Help Reduce Inflammation (Chronic Inflammatory)

Inflammation itself is an immune response from infections, illness or injuries.

A study on rats with inflammatory pain were given a daily oral treatment of 20mg of CBD for a total time of 7-14 days after injury. The study found that CBD oil reduced the pain response and sensitivity to heat and physical stimulus, such as touch. In other words, by decreasing the pain response or threshold, inflammation itself decreases.

What this means is that CBD oil appears to reduce the way the body responds these injuries. And instead of causing inflammation, the CBD oil gives therapeutic benefits that decrease the bodies negative immune response.

In a test [ Exp Dermatol. 2016] studying different compounds of cannabis including CBC, CBDV, CBG, CBGV and THCV noted that all of these phytocannabinoids showed remarkable data for ‘anti-inflammatory actions.’

The study then concluded stating that these cannabis compounds could be a ‘novel’ and ‘safe’ way for inflammation caused by cutting of the skin. Such as injuries, puncture wounds, and sharp object cuts including knives.

All of these phytocannabinoids can be found in our full spectrum CBD oil tinctures here. Non-spectrum oils are labeled (THC-Free).

14. May Help Nerve Pain

The same study that found the benefits of CBD for inflammation pain, also found that a daily oral treatment of 2.5mg-20mg of CBD to rats for 14 days after nerve pain issues seemed to relieve the pain. Stating that there is a “potential for therapeutic use of cannabidiol in chronic painful states.”

15. May Reduce Acne & Dry-Skin Syndrome: Natural Analgesic

CBD has been found to help reduce acne as an complementary benefit to its anti-inflammatory properties.

A study [ J Clin Invest. 2014] found that CBD affects the sebaceous gland, which is the gland in the skin that controls the secretion of lubricating oily matter (sebum) in which hair follicles get stuck in to create acne.

The study found that CBD inhibited the secretion of this oily matter from the sebaceous gland, therefore limiting acne formation.

Additionally, the continuation of this study [ Exp Dermatol. 2016] found that CBD ” exerted complex anti-acne effects by normalizing ‘pro-acne agents’ with in decreasing oil reproduction.

The continuation also studied the anti-inflammatory and Acne treatment effects of other Cannabis Sativa compounds, including CBC, CBG, CBGV, CBDV and THCV.

Their data found evidence that CBGV and CBG could be agents for dry-skin syndrome and CBC, THCV and CBDV show high efficiency as anti-acne agents. Stating that they have high potential for being an acne solution.

16. May Help Multiple Sclerosis

CBD has been found through clinical studies to help Multiple Sclerosis (MS). A product called Sativex, which consists of an equal ratio of Tetrahydrocannabinol (THC) and CBD was approved in Canada 2005 as a treatment for neuropathic pain in MS, as CBD binds to those receptors with endocannabinoid modulating effects.

Noted in a study, they found that CBD in combination with THC helps prevent the negative effects of THC such as anxiety, panic, intoxication, increased heart rate and the “high” effect.

17. May Help Arthritis (Rheumatoid)

CBD was analyzed on a rodent model, and was found to inhibit inflammation with rheumatoid arthritis. However, this study lacks a human model comparison.

In one randomized, double-blind human study using a Placebo and Sativex they had 56 patients use the products only at night before bed with almost an equal ratio of CBD and THC (15mg) for 5 weeks. At the end of the study, it was found that the Sativex was preferred over the placebo in terms of morning arthritis pain during rest and movement.

18. May Help Migraines and Chronic Headaches

After much research, there is only one conclusive piece of evidence regarding CBD for migraines. It happens to be an impressive study executed by Italy, and presented to the 3rd Congress of the European Academy of Neurology (EAN) in 2017.

The study was committed on 48 chronic migraine volunteers. They gave those volunteers a combination of two compounds, one containing 19% THC and the other containing 0% THC and 9% CBD, for a period of three months. Starting with 10mg of total dosage. The study noted no beneficial effects were noticed until 100mg, and then at 200mg found a 55% decrease in acute pain from migraines and chronic headaches!

They found that the relief effectiveness of the Cannabis compound combination to be in line with other migraine treatments, however, they also noticed a 43.5% reduction in acute pain intensity from migraines as well. Unlike the other treatments. This is possibly due to the effect that CBD has on the brain and neurotransmitters, in contrast to other treatments which don’t work the same way THC-CBD does.

The one caveat of this study is that they only noticed that the combination is only effective in those individuals who have been dealing with migraines and chronic headaches since childhood. Stating that it does not improve relief more than other treatments in people without previous history.

The study concludes very little CBD side effects on migraines other than occasional drowsiness and difficulty concentrating. Which is interesting as CBD has been found to help concentration in others.

Overall, study on migraines is fairly conclusive, however, there is no such thing as too much research. More studies are likely to be completed within the next few years to confirm or contradict these findings.

19. Seizures & Epilepsy Treatment:

Just last year in 2018, the first FDA-approved CBD treatment for two rare conditions of seizures and epilepsy called Epidiolex. In case you are wondering or may need use of the treatment, it costs a hefty price of $32,500 per year and contains

1. Lennox-Gastaut Syndrome: Occurs in early childhood, with the average ages being between 3-5 years old.

2. Dravet Syndrome: Occurs within the first year of life with ‘fever-related’ seizures.

This was huge step in medical treatment as the first approved treatment for Dravet Syndrome. According to FDA.gov, ” Epidiolex’s effectiveness was studied in three randomized, double-blind, placebo-controlled clinical trials involving 516 patients with either Lennox-Gastaut syndrome or Dravet syndrome. Epidiolex, taken along with other medications, was shown to be effective in reducing the frequency of seizures when compared with placebo.”

Epidiolex was found to decrease seizure rate by 42%. Side effects from the treatment included lethargy, sedation, and sleepiness. For CBD oil-related side effects click here.

Epidiolex contains 100mg/ml of CBD, as well as ” dehydrated alcohol, sesame seed oil, strawberry flavor, and sucralose.”

The FDA combined these tests with scientific research of the CBD compound itself to create treatment.

20. May Help Decrease Cigarette Smoking Habits

This one relates more to CBD vaping more than CBD oil itself, however a study [ Addict Behav. 2013] f ound a 40% decrease in cigarette use when test a placebo and CBD vape product.

The study was a randomized double blind test of 24 nicotine addicted smokers.The study concluded that their was strong evidence of CBD curbing nicotine addiction, and added more studies should be explored.

21. May Help Drug (Opioid) Withdrawal & Addiction

Initial CBD studies [ Neurotherapeutics . 2015] found that CBD helps inhibit ‘drug-seeking behavior with viritually no possibility of abuse or over-use.

22. Digestive Aid

The Endocannabinoid System (ECS) also has major proponents within normal digestive and gut function. Things such as inflammation, bowel disease, and gut permeability all run through this system.

CBD has shown beneficial effects for anti-inflammation, which may show positive potential for digestive aid. A doctor stated “i t’s interesting to note that deficiencies in the ECS are associated with pathological states including irritable bowel syndrome (IBS), colorectal cancer, and celiac disease.”

By working through the ECS system, CBD can play a role in gut-related functions.

23. Muscle Relaxer and May Speed Up Muscle Recovery

CBD Creams are becoming more and more popular within fitness, gym, and sports cultures. For good reason.

The ECS also plays a major role within muscle chemical messages from the Central Nervous System (CNS). The more chemical messages sent to the muscles to contract, the more “stiff” the muscle becomes. CBD can aid in decreasing the amount of messengers sent to muscles, thereby helping muscle relaxation.

This means that rubbing CBD creams on your muscles post-exercise or workout could help them relax, decrease muscle stiffness, decrease recovery time, decrease muscle breakdown feeling, and decreasing injury to over-worked muscles. The amount of athletes using CBD creams has multiplied within the last few years for this reason.

24. Might Have Neuroprotective Properties

There is plentiful evidence backing up CBD’s ability as a neuroprotective agent. One document noted that CBD encourages neuroplasticity, the growth of new neurons in the brain, therefore decreasing the brain’s deterioration. CBD may protect against damages from “ischemia, traumatic blows, or autoimmune and genetic disorders” and also help recovery from them.

This is also may suggests cannabidiol’s possible effectiveness in helping brain traumas or injuries. By push neuron regeneration and healing. Another study [ Surg Neurol Int . 2018] found that CBD might help with brain damage, degenerative diseases, and inflammation specifically. Which also ties into neurobehavior and improvements. This studies identifies the effectiveness of CBD paired with THC to possibly increase benefits.

An additional older study [ Pediatr Res. 2008] concluded with a suggestion stating, ” CBD administration was associated with cardiac, hemodynamic, and ventilatory beneficial effects. In conclusion, administration of CBD after HI reduced short-term brain damage and was associated with extracerebral benefits.” This study suggest similar conclusions as other studies, with CBD being a beneficial agent as a short-term aid for multiple symptoms.

Therapeutic effects of CBD have taken 4-6 weeks of constant use to start seeing any clinical effects.

Another study summarized, “cannabinoids can be neuroprotective via their immunomodulatory properties, which have been mainly attributed to CB2 receptors.” These are receptors that have a major effect on our immune system, and overall body health for fighting diseases.

25. May Benefit Heart Health

Cardiovascular health is another topic that has been explored with the benefits of CBD and CBD oil products. A study [ Br J Clin Pharmacol . 2013] found evidence suggesting that CBD affects platelet aggregation, as well as the death and sruvival of white blood cells in blood.

The study found that CBD reduced vascular tension by 40% as a maximum of pre-existing condition. This includes human arteries, involving CB1 receptor activation.

This study included additional information from previous piece of research suggesting that the cardioprotective benefits of CBD are likely due to immune control effects than actual heart benefits.

The study also found that after conduction research on rats, that CBD increased CBF, which significantly affects and decreases the probability of a stroke. A decrease in CBF shows great relevance to strokes.

The studies are preliminary, and are mostly representative of rats. However, they provide positive evidence towards the possible effects on humans.

26. May Reduce Risk of Diabetes and Obesity

By virtue of aiding chronic inflammation, cannabidiol has shown hope in helping with type 2 diabetes and insulin resistance. A scientist named Mark Rosenfeld stated, “unlike insulin and other medications for diabetes, CBD may actually suppress, reverse and perhaps cure the disease [diabetes].

There is little cold hard evidence for this, but it is a possible side effect of high dosages of CBD oil.

27. Immunomodulatory Effects

CBD is shown to have potent effects in internal body controls, [ Biochem Pharmacol. 2008] and shows significant evidence for increasing the activation of cells that control immune response and health (T cells). CBD gives evidence of increasing the magnitude of specific cell function responses that increase immune system benefits and modulation. Therefore improving immune function.

Another study found evidence that the way CBD affects the cannabinoid receptor 2 (CB2) lends to the potential of how cannabidiol may help modulate the immune system. The study acknowledges clear evidence that CBD helps immunomodulation during the inflammation process, and that CBD may affect it in four ways. This includes inducing the normal death cycle of cells, decreasing cell creation vs death (increased for tumors), producing more anti-inflammatory agents, and creating more regulatory T cells.

Targeting CB2 is cited as a possible revolutionary approach to the treatment of autoimmune and inflammatory diseases.

28. Potential in treatment of HIV-1 infection

The boost that CBD may have as an anti-inflammatory shows additional possible benefits in boosting immune cell agents against HIV-1. The way CBD works with the CB2 cell provides immune therapeutic possibilities to fight dysfunctional HIV-1 cells.

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Using human and animal models, multiple studies found that cannabidiol deactivates important HIV-1 cells, and through CB2 agonists, decreased HIV replication. The same study document noted that THC also has benefits against HIV-1 infection.

29. CBD is an effective treatment for heroin addiction:

A new study just released in May of 2019 found intense cravings are the leading cause for drug use, and any substance that reduces this craving may reduce the chance of overdose and relapse.

The study took 42 adults with an average heroin use of 13 years, and divided them into three groups to take 800mg of CBD, 400mg of CBD and a placebo respectively.

Each adult was given the dosage once daily for 3 days consecutively, and were studied for the next two weeks. During this time, they were shown pictures of nature along with pictures of heroin related items such as syringes and then were asked to state their anxiety levels.

The study found that the adults who were taking CBD showed a 2-3x reduction in heroin cravings in contrast to the placebo group. The study also showed that the difference between the CBD groups was insignificant.

30. OsteoArthritis (OA) Joint & Neuropathic Pain:

Osteoarthritis (OA) is a joint disease that has many facets and effects, such as intermittent inflammation, joint degeneration, and peripheral neuropathy.

A new study from 2017 wanted to find if CBD stopped the inflammation that ends up causing Osteoarthritis and neuropathy pain. Additionally, they wanted to analyze CBD’s anti-nociceptive properties (the ability to block the feeling or detection of injurious or painful stimulus of sensory neurons). Or in less complicated terms, the ability of CBD to stop us from feeling pain or injuries.

In order to study this, the doctors induced Osteoarthritis in male rates, and then used dosing of CBD to see the effective results. The study found that in end stage OA, the CBD reduced acute and transient joint inflammation. They also found CBD to be a neuroprotective. Meaning, it helps prevent our brains and senses from feeling the discomfort caused by OA.

The data from this study indicated that oral administration of CBD blocked OA pain. Concluding that CBD treatment prevented the later development of pain and nerve damage in OA joints, and that CBD may be a safe and useful therapeatic for treating OA joint neuropathic pain.

31. Increased Effectiveness:

CBD has been found to have the opposite effect of tolerance, with an increase in effectiveness over time. Therefore, the benefits of CBD may still occur even with a smaller dosage of the same product. Every month or two, you should decrease your dosage of CBD to see if you still receive your desired effects.

Conclusion & CBD Discount Code:

For finishing this entire article, feel free to use the Coupon Code BINOID5 for 5% off EVERY product on our store! This includes our brands such as CBDistillery, CBDfx, Medterra, and Select CBD.

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What is Delta-8 THC?

Delta-8 promises an enjoyable and therapeutic high without the overwhelming effects of THC.

Delta-8 THC is an analog of delta-9 THC. How does it affect you? Can it help you with anxiety and pain? Will it get you high?

What is delta 8 THC?

  • Delta-8 is a “minor” cannabinoid, a variant of delta-9 with small molecular differences resulting in unique effects
  • Delta-8 has many potential benefits: good for pain, inflammation, nausea, and appetite stimulation
  • Delta-8 causes a milder high than delta-9
  • Side-effects may include fatigue, drowsiness, dizziness, and headaches, as well as nausea and vomiting (in high doses)
  • Delta-8 is stuck in a federally legal grey area. Make sure it’s derived from hemp to guarantee federal legality or live in a state with legal marijuana use.
  • Delta-8 will show up in a drug test

Delta-8 THC

Type “Minor” phytocannabinoid present in all varieties of cannabis
Definition A variant of delta-9 THC
Effects Mildly psychoactive and intoxicating
Benefits May treat pain, nausea, inflammation, and appetite issues
Side effects Mild dizziness, fatigue, anxiety, and panic
Binding Binds to CB1 and CB2 receptors
Legality Federally legal when sourced from hemp
Shows up in drug test? Yes

What is Delta-8 THC?

Delta-8 THC is short for delta-8-tetrahydrocannabinol. You may also see it referred to scientifically as Δ 8 -THC.

Delta-8 is one of over 100 separate cannabinoids found in varieties of cannabis (marijuana and hemp). It’s also an “analog” or variation of delta-9 THC meaning it has almost the same molecular structure with small differences. These small differences are enough to cause unique effects in your body.

Delta-8 hasn’t received half the love it deserves, to be honest. CBD and THC are the two most popular and researched cannabinoids found in varieties of cannabis. Delta-8 THC is a lesser-known “minor” cannabinoid. Only a fractional percentage is present – maybe 1% at a push.

But let’s not confuse “minor” for useless. Delta-8’s presence in cannabis isn’t in abundance but it’s abundantly clear this underrepresented cannabinoid could very well be an excellent alternative to the delta-9 THC juggernaut.

Delta-8 vs. Delta-9

Delta-8 THC Delta-9 THC
Federally legal if sourced from hemp; federally illegal if sourced from marijuana More than 0.3% THC is federally illegal
Produces a mild-to-moderate intoxicating high Produces a strong intoxicating high
High binding affinity with CB2 receptors; less so with CB1 Very high binding affinity at CB1; less so at CB2
Molecularly similar (double bond on 8th carbon chain) Molecularly similar (double bond on 9th carbon chain)

A closer look at the differences between delta-8 and delta-9 THC’s molecular structures (and what it means).

To the untrained eye, the diagram above is just a bunch of shapes, lines, and numbers put together in a random sequence. What you’re actually looking at are the molecular structures of delta-9 THC and delta-8 THC.

Structurally, delta 8 and delta 9 look practically identical, but if you look a little closer at both, there’s actually one very small difference. You can see both structures carry double bonds on their molecular chains. These double bonds are represented as lines inside the pentagon shapes.

If you look for the numbers “8” and “9” on the delta-9 THC diagram (below), you’ll see a line running from 9 to 10 but no line from 8 to 9 inside the pentagon. This illustrates a double bond on the 9th carbon chain.

Now, if you look at the delta-8 diagram, the line inside the pentagon runs from 8 to 9. This illustrates a double bond on the 8th carbon chain.

How does this molecular difference affect how they interact with your endocannabinoid system?

The molecular difference between delta-8 and delta-9 is small but significant. It changes the way both cannabinoids interact with your endocannabinoid system (ECS), a complex and naturally-occurring biological system within all vertebrate mammals responsible for regulating and maintaining core functionality (sleep, mood, appetite, pain, stress, etc).

Delta-9 THC has a very strong affinity with your cannabinoid 1 (CB1) receptors, which are essential to your ECS and found all throughout the brain and central nervous system. When delta-9 floods the brain and grips tightly to CB1 receptors, a very euphoric high begins.

Because delta-8 THC has a slightly altered molecular structure, it fails to bind to your CB1 receptors as effectively as delta-9. This, in turn, causes a less potent high.

Delta-8 vs. THCV vs. THCA

Delta-8 THC THCV THCA
Federally legal if sourced from hemp; federally illegal if sourced from marijuana Federally illegal if sourced from hemp or marijuana Federally illegal if sourced from hemp or marijuana
Mild-to-moderate intoxication in mild-to-moderate doses No intoxication at low doses; mild intoxication in larger doses No intoxication
High binding affinity with CB2 receptors; less so with CB1 High binding affinity with both CB1 and CB2 receptors Very little binding affinity with CB1 or CB2 receptors

Delta-8 vs. CBD

Delta-8 THC CBD
Federally legal if sourced from hemp; federally illegal if sourced from marijuana Federally legal if <0.3% THC
Mild-to-moderate intoxication in mild-to-moderate doses No intoxication, but considered psychoactive
High affinity with CB2 receptors; less so with CB1 Very little binding affinity with CB1 or CB2 receptors

Delta-8 causes a high (but not one you’d expect)

Despite the molecular similarities, delta-8 THC doesn’t cause the same outrageous high as delta-9 THC does.

In fact, many believe delta-8’s high creates a consistently clear-headed experience with very little paranoia and anxiety symptoms. This type of “mild” high is making delta-8 very popular and hugely accessible to casual, beginner users.

Our experience with a delta-8 THC high:

We at CBD Oracle tried delta-8 THC in concentrate form a few weeks ago. We weren’t really expecting anything too impressive (we’re delta-9 purists at heart). However, once we gave it a go, we could see what all the fuss was about.

A delta-8 high is similar to a three-beer-buzz. Not enough to affect your brain and body to the point of overwhelming intoxication but still sufficiently stimulating and uplifting. At no point did we feel groggy or nauseous, nor did we experience any sickness or vomiting.

Comparing a delta-9 THC high with a delta-8 THC high is like comparing King-Kong to the dragon from Shrek. Both beastly in their own right but with very different temperaments. Delta-9 can be mentally destructive if you consume way more than you’re used to. Delta-8 is far tamer and easier to control.

We still recommend going easy on your first go. Try a small amount and see how you feel. Listen to your mind and body. If you feel you can have more, go for it. Just don’t consume a huge amount right at the beginning.

Is delta 8 legal?

Delta-8 THC’s legality is a little blurry and slightly more complex than delta-9 THC.

We know delta-9 THC sourced from high-THC marijuana is federally illegal and classified as a Schedule I substance under the Controlled Substances Act (CSA), alongside ecstasy and LSD. Under this scheduling, delta-9 THC has no accepted medical use and a high potential for abuse. If sourced from hemp, however, it’s federally legal but only if the product (CBD flower, CBD oil, or otherwise) carries less than 0.3% THC.

For a while, delta-8 THC wasn’t explicitly listed as a controlled substance, nor was there any law banning it. The DEA changed this in August 2020, updating the CSA to include all “tetrahydrocannabinols” as controlled substances.

However, delta-8 THC is only federally illegal if it’s derived from high-THC marijuana or the product you purchase carries more than 0.3% delta-9 THC. Essentially, it must be derived from hemp to be federally legal.

The most important thing to remember is delta-8 THC is federally legal if derived from hemp and the product carries no more than 0.3% delta-9 THC.

An update on delta-8-THC’s legality in the U.S.

Over the past couple of months, delta-8-THC’s legality across the US has been called into question, causing concern among cannabis users, manufacturers suppliers, and retailers within the cannabis industry.

The federal government closing in on delta-8

Despite hemp-derived delta-8’s supposed legality under the Agriculture Improvement Act (Farm Bill 2018), the federal government and the US Drug Enforcement Agency (DEA) believe it’s a Schedule I controlled substance.

In 2020, the DEA issued an interim final rule on hemp and its derivatives. This rule sought to bring the Farm Bill, which legalized hemp and hemp production, in line with the CSA.

The DEA’s rule specifically proposed new regulations over hemp, hemp farming, and hemp production, including the production of hemp-derived products e.g. CBD oil. It also stated all “synthetically-derived” tetrahydrocannabinols were to be listed as Schedule I controlled substances. This is where all the confusion began.

To be synthetic or not to be synthetic

Delta-8 THC is a “minor” cannabinoid i.e. only 1% can be found in hemp or marijuana. In order for producers to make delta-8 THC products, it must be converted from CBD through a structural isomerization process.

This isomerization process takes CBD, makes small but significant changes to its molecular structure, and converts it into delta-8 THC. The alterations are made using chemicals under laboratory conditions.

Now, here’s where trouble starts. Since delta-8 is synthesized using chemicals or biochemicals and not sourced directly from hemp plants, the federal government and the DEA could view it as a synthetic or synthetically-derived substance. If this is true, delta-8 can be viewed as a controlled substance.

U.S. states scramble to ban delta-8 THC

With the federal government closing in and the DEA still placing delta-8 and delta-10 alongside delta-9 in its Prohibited Narcotics List as controlled substances, US states are now beginning to take action.

15 states have either banned or restricted the use, possession, sale, or production of delta-8, which includes hemp-friendly states such as Colorado, Kentucky, and Alaska. A further six US states are currently debating delta-8’s future as we speak. Delta-8 remains legal in many states including Texas (find out more about delta-8 THC legality in Texas here).

Will delta-8 THC products cause a failed drug test?

Yes. Delta-8 can cause you to fail a drug test. Why? Regardless of whether you’re consuming delta-8 THC, delta-9 THC, or THCV, your body will break down and metabolize all THC molecules and turn them into THC metabolites.

Drug tests aren’t advanced enough to know the difference between each metabolite and will essentially lump them all together.

How long does delta-8 THC stay in your system?

Delta-8 THC metabolites stay in your body for a lot longer than you think, which is why it’s imperative to not consume any before a drug test.

You see, there’s a common misconception that once the effects of any THC molecule wear off it’s now out of the body and undetectable. This just isn’t true. Generally, after a single session with THC (delta-8 or otherwise), it’s detectable for up to a week (if not more) depending on the dose.

If you’re a frequent user, THC can be detectable for up to 3 weeks.

If you have a drug test coming up, we recommend abstaining from any THC products for at least 30-60 days leading up to a drug test. If you want to guarantee a negative drug test, abstain altogether.

Benefits of delta-8 THC

Aside from being a gentle and very beginner-friendly beast, delta-8 THC boasts its own benefits. It focuses heavily on your cannabinoid 2 (CB2) receptors, which are located all throughout your immune system.

This affinity with CB2 receptors could result in the alleviation of pain and inflammation symptoms, as well as promoting appetite stimulation via the receptors in your digestive system.

As for your CB1 receptors? Delta-8 THC’s affinity isn’t quite as strong. As we mentioned previously, it doesn’t bind as well to CB1 receptors as delta-9 THC does. The effects are slightly less potent, producing less of a high.

What does the research say about delta-8 THC’s benefits?

1. Delta 8 as a possible anti-anxiety reliever

Delta-8 THC exhibits anti-anxiety qualities but research is very limited and purely speculative. The idea behind delta-8’s alleged anti-anxiety qualities hinges primarily on anecdotal evidence. Many users on and off the internet believe moderate doses of delta-8 causes a reduction in anxiety and anxiety-related symptoms.

Unfortunately, very little preclinical or clinical studies involving human test subjects exist. If true, however, delta-8 could potentially help you with a range of anxiety symptoms.

2. Delta-8 showed no anti-depressant effects in rodent test subjects

Despite many across the internet believing delta-8 THC can produce antidepressant effects, studies on rodents show otherwise.

Researchers discovered delta-8 had no antidepressant qualities at any of the doses given, believing it to be the result of weaker binding at CB1 receptor sites. Delta-9 THC, on the other hand, produced some antidepressant effects (due to its stronger affinity with CB1 receptors).

3. Delta-8 THC could potentially reduce pain & inflammation symptoms

Delta-8 shows promise in reducing pain and inflammation symptoms in preclinical studies on rodent test subjects.

Applied topically, researchers discovered delta-8 combined with CBD activated both CB1 and CB2 receptors, thus producing a relatively potent analgesic effect. It’s unknown whether delta-8 THC can help with neuropathic pain or long-term chronic pain. Clinical studies are yet to be launched.

Though research is still limited to preclinical studies, delta-8 could be a promising cannabinoid for acute pain caused by extensive physical labor or frequent high-intensity gym sessions.

4. Delta-8 THC may stimulate appetite

Delta-8 THC could also be useful for appetite stimulation and the desire for food.

In an early 2004 study, researchers investigated the effects of low delta-8 doses on rodent test subjects for food consumption, as well as cognitive function. The rodents were given food 2.5 hours per day over the course of a 9-50 day period. On day 9, they discovered a 16% increase in food consumption and a 22% increase in the longer-term. Cognitive function also increased without overly-obvious side-effects.

Again, research here is limited to preclinical studies. However, it’s not too far-fetched to assume delta-8 could be used medicinally for chemotherapy-induced appetite loss or eating disorders. The lack of obvious side-effects makes it far more desirable.

5. Delta-8’s impressive anti-nausea and vomiting qualities

In 1995, the official god of cannabis research, Ralph Mechoulam, conducted an experimental study on delta-8 THC’s potential antiemetic properties. He administered a dose of delta-8 to eight children aged 3-13 suffering from various hematologic cancers for up to eight months.

During the entirety of the study, each child continued their course of antineoplastic (anti-tumor) medication. The doses of delta-8 were given two hours before administration of antineoplastic medication and six hours after for 24 hours.

The results were staggering. Nausea and vomiting was “completely prevented” and no overwhelming side-effects occurred.

Unfortunately, a 2005 clinical trial on delta-8’s effectiveness in combating chemotherapy-induced nausea and vomiting was terminated for reasons unknown to us.

Delta-8 side-effects are dose-dependent (don’t take too much)

Is delta-8 THC safe? Despite delta-8 THC’s milder effects, don’t think negative side-effects won’t happen (no matter how uncommon they are). It’s still an analog of delta-9 THC and does cause intoxication, reduced blood pressure, and, by extension, rapid heart rate.

A combination of decreased blood pressure and elevated heart rate can bring on panic or anxiety, especially if you’re predisposed to any of the two.

Other side-effects may include:

  • Mild drowsiness
  • Dizziness
  • Fatigue
  • Anxiety (in higher doses)
  • Panic (in higher doses)

We recommend the old saying “start low, go slow”. No need to take too much all in one go. Delta-8’s beauty lies in moderation.

Our experience with delta-8 THC side-effects:

To be perfectly honest, we didn’t experience many side effects. We felt a slight drop in blood pressure and a bit of dizziness when we stood up but it wasn’t anything too out of the ordinary. Once the effects started wearing off, there was some slight tiredness and fatigue, which is to be expected from an intoxicating compound. The next morning there was no “weed” hangover. No nausea or light-headedness. Practically like any other morning.

Where is delta-8 available to buy online?

Delta-8 THC products are available online from select cannabis brands. Delta-8 products are still in their infancy and only introduced into the market over the past year or two. You may also find a few delta-8 THC products in CBD stores.

You’re not really spoiled for choice here. Delta-8 THC products are only just being developed and released into the market. We’ve tried a couple of them and we recommend three of the best below. See a full list of Oracle’s Picks for the best delta-8 THC carts, gummies, and flower.

Extra-Strength CBD + Delta-8 THC Gummies by Kush Queen

Kush Queen was one of the first CBD brands to jump on the delta-8 THC hype. The brand’s delta-8 CBD gummies come with 10mg of CBD and 10mg of delta-8-THC. Nice and balanced. Not too potent but enough to give you the famous clear-headed high we’ve been talking about. Suitable for beginners. Highly relaxing. You only need one or two, preferably in the evening as a source of relaxation. Easy to use. Very convenient. Slow-releasing for a gradual buzz.

Delta-8 THC and CBC Tincture by Arete Hemp

Arete Hemp has released one of the strongest delta-8 THC tinctures of all time. It’s very potent and carries a whopping 1200mg of delta-8 and 500mg of CBC, alongside medium-chain-triglyceride oil (MCT) as its high-absorbing carrier. Derived purely from hemp flower. Very limited batches, so get in there quick. Best for ultimate relaxation, euphoria, and focus. We recommend this product to an intermediate cannabis user, not beginners. The potency is a little too high. Best-used in the evening with a cup of herbal tea. If you’re looking for lighter options to start with, Arete Hemp also produces some of the best delta-8 cartridges we’ve reviewed.

Delta-8 THC Pre-Rolls by Genesis

CBD Genesis offers the most natural way to consume delta-8 THC. Made from organic CBD hemp flower specially-bred for high delta-8 content. Each pre-roll carries 1.3mg of grams of premium hemp flower containing 400mg of delta-8. Because this is a smokable product, 400mg is very potent and immediately effective. No need to wait around. Again, we recommend this to seasoned cannabis veterans. The high might be a little too overwhelming for beginners.

How to properly store delta-8 THC products?

The good news is delta-8 THC is a far more robust and stable cannabinoid compared to delta-9 THC, resulting in a longer shelf-life, making it a far more desirable cannabinoid to have, particularly for users and brands.

Does delta-8’s stability mean you don’t have to worry about correct storage?

No. You should always store cannabis products correctly (delta-8 or otherwise). Stability doesn’t mean invincibility.

We recommend keeping the following storage tips in mind:

  • Make sure the container is suitable for longevity e.g. tinctures or oils should be in a dark, near-opaque glass bottle to prevent UV light from breaking down the delta-8 THC molecules
  • Avoid humid conditions (don’t store it in your bathroom)
  • Avoid direct sunlight (don’t store it on windowsills, etc)
  • Avoid high heat sources (ovens, heaters, etc)
  • Keep the lid on tightly after every use

Following these very simple rules will result in your delta-8 THC product staying fresh for up to a year, though it’s essential to remember natural degradation occurs no matter how careful you are.

What happens if I consume an out-of-date delta-8 THC product? (Trust us, it won’t kill you)

If you’ve recently used a delta-9 THC tincture or smoked a very old delta-8 THC pre-roll joint, don’t start having a panic attack just yet. There’s no need to call your doctor in tears. It’s not toxic, nor will it cause you any harm. It will, however, be noticeably less potent and effective.

We recommend purchasing a brand new delta-8 product for a fuller and better experience.

Who is delta-8 best-suited to?

Delta-8 THC is a good all-rounder. Doesn’t kick your ass the same way as delta-9 THC but will still give you a nice and healthy buzz. Perfectly suitable for a relaxing day on your own or socializing with friends.

Delta-8 THC is also good for focus and concentration. If you’re a university student, micro-dosing throughout the day could help you concentrate on your ever-growing pile of university coursework or assignments.

If you’re working from home, we suggest some caution. You don’t want to be high at work and receive an unexpected conference call with all your workmates (even worse your boss!).

If work or university stress is getting you down and you’re finding it hard to sleep, we recommend a delta-8 THC gummy as it’s slow-releasing throughout the night. It may help alleviate mild insomnia symptoms.

Gym-goers and labor-intensive workers may also benefit from delta-8’s pain-relieving qualities. Best-used right after your gym session or work shift. If you need immediate relief, we suggest smoking a delta-8 flower and pre-roll product or vaporizing a delta-8 concentrate.

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