CBD Oil Dosage: What is it for, and how much should I take?
As we’ve written before, CBD may be the most talked-about subject in the entire world of cannabis. And CBD oil has sparked a movement all its own—asking many to wonder what the right CBD oil dosage is.
CBD, of course, is the second most-prevalent cannabinoid, or “active ingredient” in the cannabis plant. What makes its sudden surge in popularity all the more remarkable is that unlike its cousin THC—the most abundant cannabinoid—CBD isn’t psychoactive. That’s right: It’s a huge component of cannabis, but it doesn’t get you high. What gives.
As it turns out, CBD is responsible for a laundry list of other effects in our bodies. In addition to mitigating some of THC’s excess psychoactivity, CBD has been shown to provide effective relief from several types of pain, anxiety and depression, and a whole range of other symptoms and conditions.
CBD is present in nearly all strains of cannabis to some degree, but because we typically want to access it for medical rather than recreational purposes, it’s often found in the form of CBD oil. Dosage is much easier to control in this concentrated form, and because consuming a dropper of amber-colored liquid tends to attract less notice than, say, sparking up a joint, it tends to be a far more discreet and socially acceptable practice.
But that invites a question: If this powerful medicine can do so much good for our bodies and our minds, how much should we really be taking? Let’s examine that question in depth.
What Is CBD Oil?
Simply put, CBD oil is an extract, or concentrate, of high-CBD cannabis in a liquid medium such as neutral coconut or palm oil. Like cannabis in flower form, it’s typically available in a variety of ratios denoting its CBD-to-THC composition. The greater the proportion of THC, the more psychoactive it will be; some CBD products—such as those derived from wild hemp—contain little to no THC and thus aren’t psychoactive at all.
Unlike smoked, vaporized or otherwise inhaled cannabis, CBD oil takes a little longer to take effect, typically from about 20 – 60 minutes depending on factors such as how much food you’ve consumed beforehand. Because this product is metabolized via the stomach, a fuller tummy means a longer onset time. That said, the effects of CBD oil typically last anywhere from two to six hours at a time, one of the reasons it’s such an in-demand remedy for relief from pain and other symptoms.
What’s the Best CBD Oil Dosage for Me?
Okay, but how much CBD oil should I take at a time? In addition to highly personal factors such as your genetics and sensitivity to different medications, it depends.
Generally speaking, if you’re using cannabis for medical purposes, it’s good policy to shoot for the lowest effective dosage. For some people, that may mean 25 milligrams (mg) a day; for others, only 3 mg may have the same beneficial effect.
Your body mass can be a helpful indicator here. A rule of thumb is to take 1– 6mg dose of CBD oil for every 10 pounds of body weight. If this has too little effect, try a slightly larger dose after a few days; if it addresses your symptoms immediately, try ramping the dose down to as low as it can still be effective.
To help guide you, here’s a partial chart provided by the Mayo Clinic intended as a rough guide:
- Chronic Pain: 2.5 – 20mg of CBD [with or without THC].
- Sleep Disorders: 40mg – 160mg of CBD.
- Epilepsy: 200 – 300mg of CBD daily.
- Loss of Appetite in Cancer Patients: 1mg of CBD with up to 2.5mg of THC for six weeks.
Best Practices with CBD Oil
No matter your CBD oil dosage, it’s good practice to dispense the oil under your tongue and then hold it there for 60 seconds. This helps speed the absorption through the blood vessels found there.
We recommend you keep a notebook with your dosage and observed effects. Because our bodies’ cannabinoid receptors change over time, it’s a safe bet your best CBD oil dosage will change as well. Keep track of your progress and adjust accordingly.
Interested in learning more about CBD? Stop by one of our Washington dispensaries to check out what we have in stock, or visit our online menu to order ahead.
CBD & CANNABIS DOSAGE GUIDE – Project CBD Interview with Dr. Sulak
It can be relatively easy to experience medical benefits from cannabis. A puff or two of tetrahydrocannabinol ( THC )-rich flower can do the trick for a lot of people.
Smoking marijuana, however, is not the be-all and end-all of cannabis therapeutics. There are many ways to experience the medical benefits of cannabis, and some of them are even non-intoxicating.
In recent years, the advent of potent cannabis oil concentrates, non-intoxicating cannabidiol ( CBD ) products, and innovative, smokeless delivery systems have transformed the therapeutic landscape and changed the national conversation about cannabis.
It’s no longer a question of whether marijuana has medical value. Now it’s about figuring out how to optimize your therapeutic use of cannabis to suit your lifestyle and situation.
FINDING YOUR OPTIMAL CANNABIS DOSAGE
Optimizing therapeutic cannabis use can be a challenge – for doctors as well as patients. Most physicians never learned about cannabis in medical school and, according to a 2017 survey, few feel they are qualified to counsel patients about dosage, CBD : THC ratios, different modes of administration, and potential side effects.
“Dosing cannabis is unlike any therapeutic agent to which I was exposed in my medical training,” says Dustin Sulak, D.O., the director of Integr8 Health, which serves patients at offices in Maine and Massachusetts. “Some patients effectively use tiny amounts of cannabis, while others use incredibly high doses. I’ve seen adult patients achieve therapeutic effects at 1 mg of total cannabinoids daily, while others consume over 2000mg daily without adverse effects.”
Cannabis comes in many different forms with a wide range of potencies, and its production and distribution have yet to be standardized in states where cannabis is legal for therapeutic use. So what’s the best way to proceed when it seems like cannabis dosage is all over the map?
MICRODOSING FOR BEGINNERS
“Most people are surprised to learn that the therapeutic effects of cannabis can be achieved at dosages lower than those required to produce euphoria or impairment,” says Dr. Sulak, who asserts that “ultra-low doses can be extremely effective, sometimes even more so than the other extreme.”
Preclinical science lends credence to the notion that a small amount of THC can confer health benefits. Oral administration of a low dose of THC (1 mg/day) resulted in significant inhibition of disease progression” in an animal model of heart atherosclerosis (hardening of the arteries), according to a 2005 report in Nature, which noted: “This effective dose is lower than the dose usually associated with psychotropic effects of THC.”
Because of federal cannabis prohibition and consequent research restrictions, clinical data is lacking to determine if low-dose THC therapy can protect against atherosclerosis in humans. But this much is certain: The practice of micro-dosing – which entails the consumption of a sub-psychoactive or slightly psychoactive dose of cannabis – is gaining popularity among those who want the medical benefits of cannabis without the buzz.
Although banned by federal law, cannabis medicine is currently accessible in the form of concentrated oil extracts, infused sublingual sprays, tinctures, edibles, gel caps, topical salves, and other products.
The successful use of cannabis as a medicine largely depends on managing its intoxicating properties. Many people enjoy the cannabis high; for others it’s unpleasant. A person’s sensitivity to THC, the main intoxicating component of cannabis, is key to implementing an effective treatment regimen.
“The practice of micro-dosing – which entails the consumption of a sub-psychoactive or slightly psychoactive dose of cannabis – is gaining popularity among those who want the medical benefits of cannabis without the buzz.”
Cannabidiol (CBD) does not cause an intoxicating high like THC. CBD can actually lessen or neutralize the THC high, depending on how much of each compound is present in a particular product. A greater ratio of CBD-to-THC means less of high. Today cannabis patients have the option of healing without feeling high.
Broadly speaking, there are three types of resin-rich cannabis and cannabis products:
- Type 1 (THC-dominant) – High THC, low CBD (famously intoxicating cannabis varietals)
- Type 2 (THC & CBD) – Mixed THC and CBD cultivars (intoxicating, but not as edgy as THC-dominant varietals)
- Type 3 (CBD-dominant) – High CBD, low THC (non-euphoric marijuana or hemp)
There’s also a fourth type – those rare cannabis cultivars that prominently express a so-called minor cannabinoid (like CBG or THCV). But in terms of what’s currently available for patients, the THC: CBD ratio is paramount and must be considered when formulating dosage strategies.
So, what’s the appropriate dosage for each of the three main types of cannabis?
“START LOW, GO SLOW”
The adage “start low and go slow” is apropos for cannabis therapy, in general, and THC titration in particular, as discussed by Caroline MacCallum and Ethan Russo in a January 2018 article in the European Journal of Internal Medicine. The authors, who are both physicians, provide sensible guidelines for health professionals and patients regarding the judicious administration of (Type 1) THC-dominant medicinal preparations.
If a new patient is going to smoke or vape THC-rich cannabis, Russo and MacCallum suggest they start with a single inhalation and wait 15 minutes before inhaling again. The effects of inhaled cannabis usually can be felt within a few minutes, thereby providing quick relief of acute distress. If need be, one can inhale an additional puff every 15 to 30 minutes “until desired symptom control is achieved.”
As for oral administration, one should keep in mind that it can take 60 to 90 minutes before the effects of a single dose are felt.
MacCallum and Russo suggest a carefully titrated regimen for consumption of ingestible THC-rich cannabis products. They recommend that patients with little or no experience using cannabis should start by ingesting the equivalent of 1.25 to 2.5 mg of THC shortly before bedtime for two days. If there are no unwanted side effects, increase the bedtime dose of THC by another 1.25 to 2.5 mg for the next two days. Continue to increase the dose of THC by an additional 1.25 to 2.5 mg every other day until the desired effects are achieved.
If there are adverse side effects, reduce the dose of THC to the prior amount that was well tolerated.
DIFFERENT TYPES OF CANNABIS, DIFFERENT DOSAGE
TYPE 1 – TITRATING THC
For adequate symptom relief, some patients may need to ingest a cannabis preparation two or three times during daylight hours in addition to their night-time regimen. Cautious titration is urged: On days 1 and 2, start with one dose of the equivalent of 2.5 mg THC; on days 3 and 4, increase to 2.5 mg THC twice a day; and, if well tolerated, up the dose incrementally to a total of 15 mg THC (divided equally throughout the day).
“Doses exceeding 20-30 mg/day may increase adverse events or induce tolerance without improving efficacy,” MacCallum and Russo warn.
Adverse events mainly pertain to THC and are dose-dependent. Very high doses are more likely to cause unwanted side effects.
For most medications, a higher dose will pack a stronger therapeutic punch. With cannabis, however, it’s not so simple. THC and other cannabis components have biphasic properties, meaning that low and high doses generate opposite effects. Small doses of cannabis tend to stimulate; large doses sedate.
In practical terms, this means that starting low and gradually upping the dose of cannabis will produce stronger effects at first. But, after a certain point, “dosage increases can result in weaker therapeutic effects,” according to Dr. Sulak, “and an increase in side effects.” It is important to note that everybody responds to THC differently and builds tolerance at different rates. Check-in with yourself often while consuming cannabis to gauge the effects and side effects.
There are some negative side effects that can result from over-consumption. Sulak observes that “symptoms of cannabis overdose closely mirror the symptoms one would expect cannabis to relieve at appropriate doses: nausea, vomiting, diarrhea, sweating, spasms, tremors, anxiety, panic attacks, paranoia, dis-coordination, and disturbed sleep. Extreme overdoses can lead to hallucinations and even acute psychosis.”
By introducing small amounts of THC into your system, and increasing the dosage slowly, you minimize the risk of negative side effects. The goal is to take a large enough dose of THC to achieve therapeutic effects and a small enough dose to minimize negative side effects.
TYPE 2 – THC AND CBD: THE POWER COUPLE
CBD and THC are the power couple of cannabis therapeutics. Both compounds have remarkable medicinal attributes, and they work better in combination than as isolates. CBD can synergistically enhance THC’s anti-inflammatory and pain-killing properties while reducing unwanted side effects.
A 2010 report in the British Journal of Pharmacologyanalyzed the effects of THC and CBD alone and in combination in an animal model of colitis. This preclinical study concluded that “CBD increased some effects of an ineffective THC dose to the level of an effective one.”
This is one of the many gifts of CBD: It can magnify the medicinal impact of a small amount of THC so that one need not consume an intoxicating dose to experience THC’s therapeutic benefits.
A clinical study published in the Journal of Pain examined the efficacy of different dosage levels of Sativex, a cannabis-derived sublingual spray with a 1:1 CBD: THC ratio, which is an approved medication in two dozen countries (but not in the United States). Of 263 cancer patients who were not finding pain relief with opiates, the group that received 21 mg of Sativex each day experienced significant improvements in pain levels, more so than the group that received 52 mg Sativex daily. And those given even higher doses (83 mg daily) reduced their pain no better than a placebo, but they experienced more adverse effects.
Although many patients do well at the lowest effective dose, some benefit from a high-dose cannabis oil regimen. Often these patients engage in a regimen that includes a substantial amount of CBD as well as THC. By reducing THC’s intoxicating effects, CBD makes high potency cannabis oil treatment easier to manage. If high doses are necessary, steady titration over several weeks will help build a tolerance to THC’s tricky intoxicating effects.
Cannabis therapeutics is personalized medicine. There is no single CBD:THC ratio or dosage that’s optimal for everyone. As little as 2.5 mg of CBD combined with a small amount of THC can have a therapeutic effect. If necessary, much higher doses of good quality CBD-rich formulations are safe and well-tolerated.
For patients new to cannabis, it may be best to start with low doses of a CBD-rich remedy (with little THC) and increase the dosage (and, if necessary, the amount of THC) step-by-step. Take a few small doses over the course of the day, rather than one big dose.
But a low-THC product is not always the best treatment option. A more balanced combination of CBD and THC could have a greater impact than CBD or THC alone.
In essence, the goal is to administer consistent, measurable doses of a CBD-rich remedy with as much THC as a person is comfortable with. Experiment, observe the effects and adjust the amount of CBD and THC until one finds the sweet spot with the right combination of both compounds.
TYPE 3 – FULL-SPECTRUM CBD-RICH EXTRACTS
Microdosing cannabis is a feasible option for those who prefer not to leap over the intoxicating threshold. High-dose CBD therapy is another way of healing without the high.
As a general rule, Type 3 CBD-dominant cannabis (with little THC) won’t make a person feel stoned. Nor will a pure CBD isolate (with no THC). But CBD isolates lack critical aromatic terpenes and other cannabinoids, which interact synergistically to enhance CBD’s therapeutic benefits. Single-molecule cannabinoids are simply not as versatile or as efficacious as whole plant formulations.
Preclinical research indicates that full-spectrum CBD-rich cannabis oil is effective at much lower doses and has a wider therapeutic window than a CBD isolate. “The therapeutic synergy observed with plant extracts results in the requirement for a lower amount of active components, with consequent reduced adverse side effects,” a 2015 Israeli study concluded. In animal studies, CBD isolates require very high – and precise – doses to be effective. Problematic drug interactions are also more likely with a high-dose CBD isolate than with whole-plant cannabis.
Hemp-derived CBD isolates and distillates are already available via numerous internet storefronts. If you’re shopping for hemp-derived products online, there can be some quality issues to address before purchasing. Drug companies are also eyeing single-molecule CBD as a treatment for intractable epilepsy, psychosis, and other diseases.
In a 2012 clinical trial involving 39 schizophrenics at a German hospital, 800 mg of pure pharmaceutical-grade CBD proved to be as effective as standard pharmaceutical treatments without causing the harsh side effects typically associated with antipsychotic drugs. But a follow-up study at Yale University found little cognitive improvement in schizophrenics who were given a CBD isolate.
Bereft of the THC stigma (and its therapeutic moxy), single-molecule CBD recently became an FDA-approved pharmaceutical for pediatric seizure disorders. This is good news for families with epileptic children that have health insurance. Anyone without health insurance won’t be able to afford Epidiolex, a nearly pure CBD remedy developed by GW Pharmaceuticals as an anti-seizure medication.
Consider the dosage range utilized in clinical trials of epidiolex. Children with catastrophic seizure disorders were given up to 20 mg of epidiolex per kg of body weight. Such high doses caused interactions with other anticonvulsant medications, requiring adjustments of the latter to avoid a toxic overdose.
By comparison, Dr. Bonni Goldstein, author of Cannabis Revealed, typically starts with a much lower dose of full-spectrum CBD-rich oil (1 mg CBD/kg of body weight) for epileptic children – with the understanding that the dose may have to be lowered or raised depending on the initial response. If necessary, Goldstein will increase the dose of CBD by increments of 0.5 mg/kg until a threshold of 5 mg/kg of body weight is reached. And that amount also may need to be adjusted.
Kids and adults metabolize drugs differently. It may seem counterintuitive, but young children can tolerate high doses of cannabis oil concentrates, including THC-rich formulations, which might be daunting for an adult. Thus, it’s not a good idea to calculate the dosage for an adult based on what works for a child.
If 1 mg/kg of CBD is an appropriate starting dose for a child, and an adult weighs 15 times more than the child, one should not assume that the correct CBD starting dose for the grown-up is 15mg/kg of body weight. That could be way too high a dose. While CBD has no known adverse effects at any dose, an excessive amount of CBD may be less effective therapeutically than a moderate dose. Similarly, it’s not a good idea to devise a dosage regimen based on data from preclinical animal studies, which usually involve high doses of single-molecule cannabinoids. Human metabolism differs from mice and rats, and data from animal models doesn’t always translate to human experience.
For people as well as pets, cannabis dosage must be individually determined. Several factors come into play, including one’s overall health and endocannabinoid tone, which are influenced by diet, exercise, sleep patterns, day-to-day stress, and genetics. Cannabis is best used as part of a healthy lifestyle.
Here are some dosage variables to consider:
- Cannabis experience. Has the patient used cannabis before? Or are they a stoner who already uses cannabis every day but isn’t getting the best results? A veteran user may need a higher dose than a new user. Or a chronic user might need a break from getting high to reboot his or her sensitivity to cannabis (see Dr. Dustin Sulak’s cannabis “sensitization protocol” on Healer.com).
- Time of day. Optimizing one’s therapeutic use of cannabis may entail using products with different CBD: THC ratios at different times of the day – more CBD for daylight hours, more THC at night.
- Preventive dosing. Prolonged low-dose therapy may be advantageous for managing chronic symptoms or to prevent disease recurrence. Preclinical studies indicate that cannabinoids have neuroprotective and cardioprotective properties that could limit the damage of a traumatic brain injury or a heart attack.
- Cannabinoid acids. Raw, unheated cannabis contains CBD and THC in their “acid” form, CBDA and THCA, which are not intoxicating. Consumed orally over several months, cannabinoid acids can be effective in very small amounts, but precise dosing is difficult when juicing raw cannabis. Other delivery systems are becoming available for CBDA-rich and THCA-rich products.
Cannabis is a safe and forgiving medicine. Figuring out how to make the most of its health-enhancing properties may involve some trial and error. No worries! At least cannabis isn’t harmful like so many FDA-approved pharmaceuticals.
So if you’re new to cannabis medicine or if you’re seeking to improve your therapeutic routine, remember this advice from Dr. Sulak: “Start low, go slow, and don’t be afraid to go all the way!”